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- W4377013948 abstract "Abstract Objective To investigate the effect of caspase-3-specific inhibitors of extracorporeal circulation (CPB) on pulmonary ischaemia-reperfusion injury in dogs. Methods Eighteen healthy mongrel dogs were divided into three groups (n = 6) by random number table method, sham-operated group (group C), ischemia-reperfusion group (group I/R) and caspase-3 specific inhibitor (group Z), and the rest of the groups were established as CPB left lung ischemia-reperfusion injury model, and group Z was given caspase-3 specific inhibitor (Z-DEVD) via femoral vein immediately after opening the left pulmonary artery. The caspase-3 specific inhibitor (Z-DEVD-fmk) 0.6mg/Kg was administered to the Z group immediately after opening the left pulmonary artery via the femoral vein. Arterial blood was collected from the femoral artery before chest opening (T1), at the time of shutdown (T2) and at the end of the experiment (T3), and arterial blood gas analysis was performed to calculate respiratory index (RI) and oxygenation index (OI). -N expression, TUNEL assay for apoptosis and HE assay for pathological changes in lung tissue at each time point. Results The expression of RI, Cleaved-caspase3, NLRP3, Clleaved-caspase-1, GSDME-N and apoptotic index in lung tissue increased in the I/R group at T2 and T3 compared with the C group, while the OI decreased (P < 0.05); compared with the I/R group at T3, the expression of RI, Cleaved-caspase3 and apoptotic index in the Z group increased. caspase3, NLRP3, Clleaved-caspase-1, GSDME-N expression and apoptotic index decreased and OI increased in the Z group compared with the I/R group at T3 (P < 0.05); no significant apoptotic cells were seen in the C group at T3; apoptotic cells increased in the I/R group after open left pulmonary arteriovenous reperfusion stimulation, while the Z group had fewer positive cells than the I/R group. Conclusion Caspase-3-specific inhibitors can improve lung function and reduce apoptosis in lung tissue after CPB, it also reduce oxidative stress level and inflammation level. These effects may be achieved by regulating Caspase-3/GSDME signaling pathway and inhibiting pyroptosis." @default.
- W4377013948 created "2023-05-19" @default.
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- W4377013948 date "2023-05-18" @default.
- W4377013948 modified "2023-10-16" @default.
- W4377013948 title "Caspase-3 specific inhibitors improve lung function in dogs with lung hypoxia reperfusion injury by regulating the Caspase-3/GSDME signaling pathway" @default.
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- W4377013948 doi "https://doi.org/10.21203/rs.3.rs-2930910/v1" @default.
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