Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377014045> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4377014045 abstract "Background and Objectives: Ultrasound (US) is a non-invasive tool for the in-vivo detection of peripheral nerve alterations. Materials and Methods: In this study we applied nerve US to assist the discrimination between the spectrum of Amyotrophic Lateral Sclerosis (ALS, n=11), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP, n=5) and genetically confirmed Charcot-Marie-Tooth disease (CMT, n=5). All participants and n=15 controls without neurological diseases underwent high-resolution US of the bilateral tibial nerve. Nerve cross-sectional area (CSA) and nerve microvascular blood flow were compared between the groups and related to cerebrospinal fluid (CSF) measures, clinical symptoms and nerve conduction studies. Analyses are part of a larger multimodal study on the comparison between US and 7 Tesla (T) magnetic resonance neurography (MRN). Results: Patients and controls were matched with respect to their demographical data. CMT had the longest disease duration, followed by CIDP and ALS. CSA was related to age, weight and disease duration. CSA was larger in CMT and CIDP compared to ALS and controls. Blood flow was greatest in CIDP, and higher than in CMT, ALS and controls. In ALS, greater CSA was correlated with greater CSF total protein and higher albumin quotient. US measures did not correlate with clinical scores or nerve conduction studies in any of the subgroups. Conclusion: Our results point towards the feasibility of CSA and blood flow to discriminate between ALS, CIDP and CMT, even in small sample sized groups. In ALS, larger CSA could indicate an inflammatory disease subtype characterized by reduced blood-nerve barrier integrity. Our upcoming analysis will focus on the additive value of 7T MRN in combination with US to disentangle the spectrum between more inflammatory or more degenerative disease variants along the disease groups." @default.
- W4377014045 created "2023-05-19" @default.
- W4377014045 creator A5005633849 @default.
- W4377014045 creator A5028251660 @default.
- W4377014045 creator A5034872348 @default.
- W4377014045 creator A5035967739 @default.
- W4377014045 creator A5044736277 @default.
- W4377014045 creator A5048101991 @default.
- W4377014045 creator A5056322606 @default.
- W4377014045 creator A5068907567 @default.
- W4377014045 creator A5071062652 @default.
- W4377014045 creator A5083411155 @default.
- W4377014045 creator A5086875951 @default.
- W4377014045 creator A5089694789 @default.
- W4377014045 date "2023-05-18" @default.
- W4377014045 modified "2023-10-16" @default.
- W4377014045 title "Peripheral Nerve Ultrasound for the Differentiation between ALS, Inflammatory and Hereditary Polyneuropathies" @default.
- W4377014045 doi "https://doi.org/10.20944/preprints202305.1315.v1" @default.
- W4377014045 hasPublicationYear "2023" @default.
- W4377014045 type Work @default.
- W4377014045 citedByCount "0" @default.
- W4377014045 crossrefType "posted-content" @default.
- W4377014045 hasAuthorship W4377014045A5005633849 @default.
- W4377014045 hasAuthorship W4377014045A5028251660 @default.
- W4377014045 hasAuthorship W4377014045A5034872348 @default.
- W4377014045 hasAuthorship W4377014045A5035967739 @default.
- W4377014045 hasAuthorship W4377014045A5044736277 @default.
- W4377014045 hasAuthorship W4377014045A5048101991 @default.
- W4377014045 hasAuthorship W4377014045A5056322606 @default.
- W4377014045 hasAuthorship W4377014045A5068907567 @default.
- W4377014045 hasAuthorship W4377014045A5071062652 @default.
- W4377014045 hasAuthorship W4377014045A5083411155 @default.
- W4377014045 hasAuthorship W4377014045A5086875951 @default.
- W4377014045 hasAuthorship W4377014045A5089694789 @default.
- W4377014045 hasBestOaLocation W43770140451 @default.
- W4377014045 hasConcept C126322002 @default.
- W4377014045 hasConcept C126838900 @default.
- W4377014045 hasConcept C142724271 @default.
- W4377014045 hasConcept C143753070 @default.
- W4377014045 hasConcept C158846371 @default.
- W4377014045 hasConcept C159654299 @default.
- W4377014045 hasConcept C203014093 @default.
- W4377014045 hasConcept C2777052087 @default.
- W4377014045 hasConcept C2778691916 @default.
- W4377014045 hasConcept C2779134260 @default.
- W4377014045 hasConcept C2779651940 @default.
- W4377014045 hasConcept C2779658331 @default.
- W4377014045 hasConcept C2779867792 @default.
- W4377014045 hasConcept C2780596555 @default.
- W4377014045 hasConcept C2994188736 @default.
- W4377014045 hasConcept C71924100 @default.
- W4377014045 hasConcept C90924648 @default.
- W4377014045 hasConceptScore W4377014045C126322002 @default.
- W4377014045 hasConceptScore W4377014045C126838900 @default.
- W4377014045 hasConceptScore W4377014045C142724271 @default.
- W4377014045 hasConceptScore W4377014045C143753070 @default.
- W4377014045 hasConceptScore W4377014045C158846371 @default.
- W4377014045 hasConceptScore W4377014045C159654299 @default.
- W4377014045 hasConceptScore W4377014045C203014093 @default.
- W4377014045 hasConceptScore W4377014045C2777052087 @default.
- W4377014045 hasConceptScore W4377014045C2778691916 @default.
- W4377014045 hasConceptScore W4377014045C2779134260 @default.
- W4377014045 hasConceptScore W4377014045C2779651940 @default.
- W4377014045 hasConceptScore W4377014045C2779658331 @default.
- W4377014045 hasConceptScore W4377014045C2779867792 @default.
- W4377014045 hasConceptScore W4377014045C2780596555 @default.
- W4377014045 hasConceptScore W4377014045C2994188736 @default.
- W4377014045 hasConceptScore W4377014045C71924100 @default.
- W4377014045 hasConceptScore W4377014045C90924648 @default.
- W4377014045 hasLocation W43770140451 @default.
- W4377014045 hasOpenAccess W4377014045 @default.
- W4377014045 hasPrimaryLocation W43770140451 @default.
- W4377014045 hasRelatedWork W113441387 @default.
- W4377014045 hasRelatedWork W1968157847 @default.
- W4377014045 hasRelatedWork W2027879458 @default.
- W4377014045 hasRelatedWork W2416500976 @default.
- W4377014045 hasRelatedWork W2419659295 @default.
- W4377014045 hasRelatedWork W25458322 @default.
- W4377014045 hasRelatedWork W2863071074 @default.
- W4377014045 hasRelatedWork W2957954342 @default.
- W4377014045 hasRelatedWork W2974791644 @default.
- W4377014045 hasRelatedWork W3015611287 @default.
- W4377014045 isParatext "false" @default.
- W4377014045 isRetracted "false" @default.
- W4377014045 workType "article" @default.