FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377014075> ?p ?o ?g. }

• W4377014075 endingPage "997" @default.
• W4377014075 startingPage "994" @default.
• W4377014075 abstract "Real-world evidence regarding the value of integrating genomic profiling (GP) in managing cancer of unknown primary (CUP) is limited. We assessed this clinical utility using a prospective trial of 158 patients with CUP (October 2016-September 2019) who underwent GP using next-generation sequencing designed to identify genomic alterations (GAs). Only 61 (38.6%) patients had sufficient tissue for successful profiling. GAs were seen in 55 (90.2%) patients of which GAs with US Food and Drug Administration-approved genomically matched therapy were seen in 25 (40.9%) patients. A change in therapy was recommended and implemented (primary endpoint of the study) in 16 (10.1%) and 4 (2.5%) patients of the entire study cohort, respectively. The most common reason for inability to implement the profiling-guided therapy was worsening of performance status (56.3%). Integrating GP in management of CUP is feasible but challenging because of paucity of tissue and aggressive natural history of the disease and requires innovative precision strategies." @default.
• W4377014075 created "2023-05-19" @default.
• W4377014075 creator A5003827387 @default.
• W4377014075 creator A5004583668 @default.
• W4377014075 creator A5005756574 @default.
• W4377014075 creator A5009153348 @default.
• W4377014075 creator A5024146796 @default.
• W4377014075 creator A5032970786 @default.
• W4377014075 creator A5046135731 @default.
• W4377014075 creator A5047634549 @default.
• W4377014075 creator A5053017453 @default.
• W4377014075 creator A5064540759 @default.
• W4377014075 creator A5065585995 @default.
• W4377014075 creator A5066894564 @default.
• W4377014075 creator A5069988175 @default.
• W4377014075 creator A5070962807 @default.
• W4377014075 creator A5073383381 @default.
• W4377014075 creator A5081831776 @default.
• W4377014075 creator A5084360066 @default.
• W4377014075 creator A5085348528 @default.
• W4377014075 creator A5085413923 @default.
• W4377014075 creator A5088389768 @default.
• W4377014075 creator A5088853428 @default.
• W4377014075 date "2023-05-18" @default.
• W4377014075 modified "2023-09-30" @default.
• W4377014075 title "Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study" @default.
• W4377014075 cites W2007523256 @default.
• W4377014075 cites W2078276694 @default.
• W4377014075 cites W2637886930 @default.
• W4377014075 cites W2802321540 @default.
• W4377014075 cites W2911210943 @default.
• W4377014075 cites W3010680101 @default.
• W4377014075 cites W3089562193 @default.
• W4377014075 cites W3133328851 @default.
• W4377014075 cites W3135829038 @default.
• W4377014075 cites W4289524748 @default.
• W4377014075 doi "https://doi.org/10.1093/jnci/djad095" @default.
• W4377014075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37202363" @default.
• W4377014075 hasPublicationYear "2023" @default.
• W4377014075 type Work @default.
• W4377014075 citedByCount "0" @default.
• W4377014075 crossrefType "journal-article" @default.
• W4377014075 hasAuthorship W4377014075A5003827387 @default.
• W4377014075 hasAuthorship W4377014075A5004583668 @default.
• W4377014075 hasAuthorship W4377014075A5005756574 @default.
• W4377014075 hasAuthorship W4377014075A5009153348 @default.
• W4377014075 hasAuthorship W4377014075A5024146796 @default.
• W4377014075 hasAuthorship W4377014075A5032970786 @default.
• W4377014075 hasAuthorship W4377014075A5046135731 @default.
• W4377014075 hasAuthorship W4377014075A5047634549 @default.
• W4377014075 hasAuthorship W4377014075A5053017453 @default.
• W4377014075 hasAuthorship W4377014075A5064540759 @default.
• W4377014075 hasAuthorship W4377014075A5065585995 @default.
• W4377014075 hasAuthorship W4377014075A5066894564 @default.
• W4377014075 hasAuthorship W4377014075A5069988175 @default.
• W4377014075 hasAuthorship W4377014075A5070962807 @default.
• W4377014075 hasAuthorship W4377014075A5073383381 @default.
• W4377014075 hasAuthorship W4377014075A5081831776 @default.
• W4377014075 hasAuthorship W4377014075A5084360066 @default.
• W4377014075 hasAuthorship W4377014075A5085348528 @default.
• W4377014075 hasAuthorship W4377014075A5085413923 @default.
• W4377014075 hasAuthorship W4377014075A5088389768 @default.
• W4377014075 hasAuthorship W4377014075A5088853428 @default.
• W4377014075 hasConcept C111919701 @default.
• W4377014075 hasConcept C126322002 @default.
• W4377014075 hasConcept C143998085 @default.
• W4377014075 hasConcept C187191949 @default.
• W4377014075 hasConcept C188816634 @default.
• W4377014075 hasConcept C203092338 @default.
• W4377014075 hasConcept C41008148 @default.
• W4377014075 hasConcept C535046627 @default.
• W4377014075 hasConcept C60644358 @default.
• W4377014075 hasConcept C71924100 @default.
• W4377014075 hasConcept C86803240 @default.
• W4377014075 hasConceptScore W4377014075C111919701 @default.
• W4377014075 hasConceptScore W4377014075C126322002 @default.
• W4377014075 hasConceptScore W4377014075C143998085 @default.
• W4377014075 hasConceptScore W4377014075C187191949 @default.
• W4377014075 hasConceptScore W4377014075C188816634 @default.
• W4377014075 hasConceptScore W4377014075C203092338 @default.
• W4377014075 hasConceptScore W4377014075C41008148 @default.
• W4377014075 hasConceptScore W4377014075C535046627 @default.
• W4377014075 hasConceptScore W4377014075C60644358 @default.
• W4377014075 hasConceptScore W4377014075C71924100 @default.
• W4377014075 hasConceptScore W4377014075C86803240 @default.
• W4377014075 hasFunder F4320308826 @default.
• W4377014075 hasFunder F4320332161 @default.
• W4377014075 hasIssue "8" @default.
• W4377014075 hasLocation W43770140751 @default.
• W4377014075 hasLocation W43770140752 @default.
• W4377014075 hasOpenAccess W4377014075 @default.
• W4377014075 hasPrimaryLocation W43770140751 @default.
• W4377014075 hasRelatedWork W2055141553 @default.
• W4377014075 hasRelatedWork W2076993109 @default.
• W4377014075 hasRelatedWork W2159723344 @default.
• W4377014075 hasRelatedWork W2169374891 @default.
• W4377014075 hasRelatedWork W2295722933 @default.
• W4377014075 hasRelatedWork W2411569915 @default.

• next