FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377014295> ?p ?o ?g. }

• W4377014295 endingPage "e310" @default.
• W4377014295 startingPage "e300" @default.
• W4377014295 abstract "Background and Objectives Mean diffusivity (MD) of diffusion MRI (dMRI) has been used to measure cortical and subcortical microstructural properties. This study investigated relationships of cortical and subcortical MD, clinical progression, and fluid biomarkers in Parkinson disease (PD). Methods This longitudinal study using data from the Parkinson's Progression Markers Initiative was collected from April 2011 to July 2022. Clinical symptoms were assessed with Movement Disorder Society–sponsored revision of the Unified Parkinson's Disease Rating Scale (UPDRS) and Montreal Cognitive Assessment (MoCA) scores. Clinical assessments were followed up to 5 years. Linear mixed-effects (LME) models were performed to examine associations of MD and the annual rate of changes in clinical scores. Partial correlation analysis was conducted to examine the associations of MD and fluid biomarker levels. Results A total of 174 patients with PD (age 61.9 ± 9.7 years, 63% male) with baseline dMRI and at least 2 years of clinical follow-up were included. Results of LME models revealed a significant association between MD values, predominantly in subcortical regions, temporal lobe, occipital lobe, and frontal lobe, and annual rate of changes in clinical scores (UPDRS-Part-I, standardized β > 2.35; UPDRS-Part-II, standardized β > 2.34; postural instability and gait disorder score, standardized β > 2.47; MoCA, standardized β < −2.42; all p < 0.05, false discovery rate [FDR] corrected). In addition, MD was associated with the levels of neurofilament light chain in serum ( r > 0.22) and α-synuclein (right putamen r = 0.31), β-amyloid 1–42 (left hippocampus r = −0.30), phosphorylated tau at 181 threonine position ( r > 0.26), and total tau ( r > 0.23) in CSF at baseline (all p < 0.05, FDR corrected). Furthermore, the β coefficients derived from MD and annual rate of changes in the clinical score recapitulated the spatial distribution of dopamine (DAT, D1, and D2), glutamate (mGluR5 and NMDA), serotonin (5-HT 1a and 5-HT 2a ), cannabinoid (CB1), and γ-amino butyric acid A receptor neurotransmitter receptors/transporters ( p < 0.05, FDR corrected) derived from PET scans in the brain of healthy volunteers. Discussion In this cohort study, cortical and subcortical MD values at baseline were associated with clinical progression and baseline fluid biomarkers, suggesting that microstructural properties could be useful for stratification of patients with fast clinical progression." @default.
• W4377014295 created "2023-05-19" @default.
• W4377014295 creator A5027157675 @default.
• W4377014295 creator A5059010780 @default.
• W4377014295 creator A5061265927 @default.
• W4377014295 creator A5069654499 @default.
• W4377014295 creator A5076400419 @default.
• W4377014295 creator A5080019095 @default.
• W4377014295 date "2023-05-18" @default.
• W4377014295 modified "2023-09-28" @default.
• W4377014295 title "Association of Cortical and Subcortical Microstructure With Clinical Progression and Fluid Biomarkers in Patients With Parkinson Disease" @default.
• W4377014295 cites W1522448920 @default.
• W4377014295 cites W1987259395 @default.
• W4377014295 cites W1988494453 @default.
• W4377014295 cites W1999702935 @default.
• W4377014295 cites W2035618305 @default.
• W4377014295 cites W2051768564 @default.
• W4377014295 cites W2057169040 @default.
• W4377014295 cites W2068606962 @default.
• W4377014295 cites W2076944909 @default.
• W4377014295 cites W2077667106 @default.
• W4377014295 cites W2084373725 @default.
• W4377014295 cites W2089085990 @default.
• W4377014295 cites W2095334048 @default.
• W4377014295 cites W2106179404 @default.
• W4377014295 cites W2107665951 @default.
• W4377014295 cites W2109033202 @default.
• W4377014295 cites W2130410032 @default.
• W4377014295 cites W2131307089 @default.
• W4377014295 cites W2145271343 @default.
• W4377014295 cites W2164253272 @default.
• W4377014295 cites W2782268421 @default.
• W4377014295 cites W2801006829 @default.
• W4377014295 cites W2803113191 @default.
• W4377014295 cites W2809220255 @default.
• W4377014295 cites W2896849966 @default.
• W4377014295 cites W2898850833 @default.
• W4377014295 cites W2925961249 @default.
• W4377014295 cites W2963495948 @default.
• W4377014295 cites W2967878847 @default.
• W4377014295 cites W2989595882 @default.
• W4377014295 cites W2991532291 @default.
• W4377014295 cites W2996080671 @default.
• W4377014295 cites W3016954952 @default.
• W4377014295 cites W3034879277 @default.
• W4377014295 cites W3040745884 @default.
• W4377014295 cites W3042257464 @default.
• W4377014295 cites W3168853210 @default.
• W4377014295 cites W3179839425 @default.
• W4377014295 cites W3204170202 @default.
• W4377014295 cites W3210471919 @default.
• W4377014295 cites W3215211915 @default.
• W4377014295 cites W4200128795 @default.
• W4377014295 cites W4206481149 @default.
• W4377014295 cites W4213390777 @default.
• W4377014295 cites W4233451690 @default.
• W4377014295 cites W4280555112 @default.
• W4377014295 cites W4281766093 @default.
• W4377014295 cites W4281832698 @default.
• W4377014295 cites W4285493017 @default.
• W4377014295 cites W4292680960 @default.
• W4377014295 cites W4307494802 @default.
• W4377014295 doi "https://doi.org/10.1212/wnl.0000000000207408" @default.
• W4377014295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37202161" @default.
• W4377014295 hasPublicationYear "2023" @default.
• W4377014295 type Work @default.
• W4377014295 citedByCount "1" @default.
• W4377014295 countsByYear W43770142952023 @default.
• W4377014295 crossrefType "journal-article" @default.
• W4377014295 hasAuthorship W4377014295A5027157675 @default.
• W4377014295 hasAuthorship W4377014295A5059010780 @default.
• W4377014295 hasAuthorship W4377014295A5061265927 @default.
• W4377014295 hasAuthorship W4377014295A5069654499 @default.
• W4377014295 hasAuthorship W4377014295A5076400419 @default.
• W4377014295 hasAuthorship W4377014295A5080019095 @default.
• W4377014295 hasConcept C118552586 @default.
• W4377014295 hasConcept C126322002 @default.
• W4377014295 hasConcept C138496976 @default.
• W4377014295 hasConcept C15744967 @default.
• W4377014295 hasConcept C185592680 @default.
• W4377014295 hasConcept C2776632958 @default.
• W4377014295 hasConcept C2777127467 @default.
• W4377014295 hasConcept C2779134260 @default.
• W4377014295 hasConcept C2779483572 @default.
• W4377014295 hasConcept C2779714222 @default.
• W4377014295 hasConcept C2779734285 @default.
• W4377014295 hasConcept C2781197716 @default.
• W4377014295 hasConcept C55493867 @default.
• W4377014295 hasConcept C71924100 @default.
• W4377014295 hasConcept C83849319 @default.
• W4377014295 hasConceptScore W4377014295C118552586 @default.
• W4377014295 hasConceptScore W4377014295C126322002 @default.
• W4377014295 hasConceptScore W4377014295C138496976 @default.
• W4377014295 hasConceptScore W4377014295C15744967 @default.
• W4377014295 hasConceptScore W4377014295C185592680 @default.
• W4377014295 hasConceptScore W4377014295C2776632958 @default.
• W4377014295 hasConceptScore W4377014295C2777127467 @default.
• W4377014295 hasConceptScore W4377014295C2779134260 @default.

• next