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- W4377014314 abstract "Abstract Background To characterise the diagnostic performance of 18F-Fluorocholine PET/CT (FCH-PET/CT) to localise parathyroid adenomas (PA) in primary hyperparathyroidism (pHPT) when ultrasound (US) and MIBI-Scan (MS) failed - intraoperative correlation and one year follow up. Methods Beginning in 07/2017 FCH-PET/CT was employed in patients with proven pHPT in whom US and MS delivered either incongruent or negative findings. All patients were offered cervical explorations with intraoperative PTH-monitoring (IO-PTH) and followed for 12 months postoperatively. Imaging results were correlated to operative findings and histopathologic reports and to short term biochemical outcome as well as one-year postoperative follow-up data. Results From 07/2017 to 11/2022, 1085 patients were operated for pHPT. In this period, 215 FCH-PET/CT were performed suggesting PA(s) in 176, 6 false positive, and 33 false negative (sensitivity 84.2%, PPV 96.7%). Of the 95 cases were US and MIBI both gave negative results, FCH-PET/CT accurately localised PA(s) to the respective side of the neck in all the 72 FEC-PET-positive cases (global sensitivity of 75.8%); and was negative in 23 (24.2%). In the 12-month postoperative follow up (currently matched by 61/95) there was no biochemical persistent disease. However, 3 patients exhibited PTH or calcium at the upper limit of norme, thus, a recurrence cannot be reliably excluded so far. Conclusion FCH-PET/CT allows for planned unilateral and focused as opposed to bilateral explorations, especially when preoperative parathyroid localisation with US and MiBI fails. We, therefore, suggest FCH-PET/CT as the preferred tool for the localisation of the “negative” PA." @default.
- W4377014314 created "2023-05-19" @default.
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- W4377014314 date "2023-05-01" @default.
- W4377014314 modified "2023-10-18" @default.
- W4377014314 title "A-310 18F-FLUOROCHOLINE-PET/CT IS THE BETTER TOOL TO LOCALISE “NEGATIVE” PARATHYROID ADENOMAS – INTRAOPERATIVE CORRELATION AND 12 MONTH POSTOPERATIVE RESULTS" @default.
- W4377014314 doi "https://doi.org/10.1093/bjs/znad100.012" @default.
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