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- W4377014345 abstract "Abstract While disgust originates in the hard-wired mammalian distaste response, the conscious experience of disgust in humans strongly depends on subjective appraisal and may even extend to sociomoral contexts. In a series of studies, we combined functional magnetic resonance imaging (fMRI) with machine-learning based predictive modeling to establish a comprehensive neurobiological model of subjective disgust. The neurofunctional signature accurately predicted momentary self-reported subjective disgust across discovery ( n =78) and pre-registered validation ( n =30) cohorts and generalized across core disgust ( n =26) and sociomoral (unfair offers; n =43) contexts. Disgust experience was encoded in distributed cortical and subcortical systems, and exhibited distinct and shared neural representations with subjective fear or negative affect in interoceptive-emotional awareness and conscious appraisal systems while the signatures most accurately predicted the respective target experience. We provide an accurate fMRI-signature for disgust with a high potential to resolve ongoing evolutionary and clinical debates." @default.
- W4377014345 created "2023-05-19" @default.
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- W4377014345 date "2023-05-18" @default.
- W4377014345 modified "2023-10-03" @default.
- W4377014345 title "Rotten to the core – a neurofunctional signature of subjective core disgust generalizes to socio-moral contexts" @default.
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- W4377014345 doi "https://doi.org/10.1101/2023.05.18.541259" @default.
- W4377014345 hasPublicationYear "2023" @default.
- W4377014345 type Work @default.