FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377014483> ?p ?o ?g. }

• W4377014483 endingPage "S703" @default.
• W4377014483 startingPage "S702" @default.
• W4377014483 abstract "Right bundle branch block (RBBB) following transcatheter aortic valve replacement (TAVR) for aortic stenosis is uncommon. However, its incidence and prognosis have not been well-described. To characterize the incidence of post-TAVR RBBB alongside its associated risk of permanent pacemaker (PPM) implantation and mortality. All patients ≥18 years who underwent TAVR at the Mayo Clinic Enterprise from June 2010 to May 2021 were considered; patients with pre-TAVR RBBB and/or PPM were excluded from the analysis. Clinical history, imaging variables, and electrocardiographic data were abstracted from the electronic medical records. Post-TAVR RBBB, defined as new onset RBBB in the postprocedure period, was manually verified by the study authors. The risks of PPM implantation (within 90-days post-TAVR) and mortality following TAVR were compared between patients with and without post-TAVR RBBB using the Kaplan-Meier method and Cox proportional hazards modeling. Out of 1992 patients included, 15 (0.75%) experienced new RBBB post-TAVR. There was a higher proportion of patients who had valve oversizing among patients with new RBBB post-TAVR versus not (17.9% versus 10.0%, p=0.034). There were no other significant differences in demographics or clinical characteristics between patients with and without post-TAVR RBBB including age at TAVR, sex, type of valve implanted, valve size, aortic valve calcium score, or left ventricular ejection fraction (Table 1). Ten patients (66.7%) with post-TAVR RBBB experienced high-grade atrioventricular block (≥2 consecutive blocked P waves) and subsequently underwent PPM implantation (median 4 days; interquartile range 1-90 days), compared to 268/1977 (13.6%) without RBBB (Figure 1). After adjustment for age, sex, balloon expandable valve, annulus diameter, and valve oversizing, post-TAVR RBBB was significantly associated with PPM implantation (hazard ratio [HR] 8.36, 95% confidence interval [CI] 4.19-16.7; p<0.001). No statistically significant increase in mortality was seen with post-TAVR RBBB (HR 0.83, 95% CI 0.33-2.11; p=0.69) following adjustment for age and sex. Although encountered rarely, post-TAVR RBBB was associated with an elevated risk of PPM implantation. The mechanisms for its development and its clinical prognosis require further study.Tabled 1Table 1: Baseline characteristics of study cohortMedian (IQR) or No. (%) of patientsVariableNNo RBBB (N=1977)New-Onset RBBB (N=15)P-valueAge at TAVR1,99281.3 (75.4, 86.0)82.6 (78.8, 87.4)0.45Sex (Males)1,9921,111 (56.2%)9 (60.0%)0.80Balloon Expandable Valve1,9921,744 (88.2%)12 (80.0%)0.41Valve size1,99226.0 (23.0, 29.0)26.0 (24.5, 29.0)0.49Annulus Area (cmˆ2) based on CT1,8504.7 (4.0, 5.4)4.6 (4.3, 5.1)0.81Annulus Diameter (mm)1,93027.0 (25.0, 29.1)26.0 (25.1, 28.8)0.87Valve Oversizing *1,85010.0 (3.0, 18.5)17.9 (15.4, 23.4)0.034LVEF (%)1,89762.0 (55.0, 66.0)61.5 (54.2, 67.8)0.97AV Peak Velocity1,8974.2 (4.0, 4.6)4.1 (4.0, 4.3)0.42AV Mean Gradient1,89743.0 (38.0, 51.0)41.5 (41.0, 44.8)0.76AV Area1,8970.8 (0.7, 0.9)0.9 (0.8, 1.0)0.33LVOT AV Velocity Ratio1,8970.2 (0.2, 0.2)0.2 (0.2, 0.3)0.47LVOT AV TVI Ratio1,8970.2 (0.2, 0.2)0.2 (0.2, 0.3)0.51LVOT Dimension1,7292.2 (2.1, 2.3)2.2 (2.1, 2.3)0.77LV Geometry9710.64Concentric Hypertrophy359 (37.4%)5 (45.5%)Concentric Remodeling264 (27.5%)2 (18.2%)Eccentric Hypertrophy158 (16.5%)3 (27.3%)Normal Geometry179 (18.6%)1 (9.1%)LVED Dimension1,55649.0 (45.0, 53.0)48.0 (43.0, 53.5)0.64Aortic Valve Calcium Score1,7302,281.0 (1,556.5, 3,169.5)2,729.0 (1,979.1, 3,480.5)0.31Myocardial Infarct1,987137 (6.9%)2 (13.3%)0.28Congestive Heart Failure1,987522 (26.5%)5 (33.3%)0.56Charlson Comorbidity Index1,9872.0 (0.0, 4.0)2.0 (1.0, 4.0)0.61STS Risk Score1,7304.8 (3.0, 8.0)4.0 (3.1, 9.2)0.86P-values result from a Wilcoxon rank sum test (continuous variables) or Fisher’s exact test (categorical variables). *Valve oversizing = (Nominal Area / Annulus area (mm)) -1) *100 AV – aortic valve; CT – computed tomography; IQR – interquartile range; LVEF – left ventricular ejection fraction; LVOT – left ventricular outflow tract; STS – Society of Thoracic Surgeons; TAVR – transcatheter aortic valve replacement; TVI - tissue velocity index Open table in a new tab" @default.
• W4377014483 created "2023-05-19" @default.
• W4377014483 creator A5008299307 @default.
• W4377014483 creator A5008790942 @default.
• W4377014483 creator A5011432597 @default.
• W4377014483 creator A5020379926 @default.
• W4377014483 creator A5027865922 @default.
• W4377014483 creator A5044601513 @default.
• W4377014483 creator A5059428313 @default.
• W4377014483 creator A5069790289 @default.
• W4377014483 creator A5080483235 @default.
• W4377014483 creator A5084156910 @default.
• W4377014483 date "2023-05-01" @default.
• W4377014483 modified "2023-09-27" @default.
• W4377014483 title "PO-05-019 WHEN RIGHT IS WRONG: INCIDENCE AND OUTCOMES OF RIGHT BUNDLE BRANCH BLOCK FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT" @default.
• W4377014483 doi "https://doi.org/10.1016/j.hrthm.2023.03.1460" @default.
• W4377014483 hasPublicationYear "2023" @default.
• W4377014483 type Work @default.
• W4377014483 citedByCount "0" @default.
• W4377014483 crossrefType "journal-article" @default.
• W4377014483 hasAuthorship W4377014483A5008299307 @default.
• W4377014483 hasAuthorship W4377014483A5008790942 @default.
• W4377014483 hasAuthorship W4377014483A5011432597 @default.
• W4377014483 hasAuthorship W4377014483A5020379926 @default.
• W4377014483 hasAuthorship W4377014483A5027865922 @default.
• W4377014483 hasAuthorship W4377014483A5044601513 @default.
• W4377014483 hasAuthorship W4377014483A5059428313 @default.
• W4377014483 hasAuthorship W4377014483A5069790289 @default.
• W4377014483 hasAuthorship W4377014483A5080483235 @default.
• W4377014483 hasAuthorship W4377014483A5084156910 @default.
• W4377014483 hasBestOaLocation W43770144831 @default.
• W4377014483 hasConcept C119060515 @default.
• W4377014483 hasConcept C120665830 @default.
• W4377014483 hasConcept C121332964 @default.
• W4377014483 hasConcept C126322002 @default.
• W4377014483 hasConcept C164705383 @default.
• W4377014483 hasConcept C2778198053 @default.
• W4377014483 hasConcept C2780007028 @default.
• W4377014483 hasConcept C2780026749 @default.
• W4377014483 hasConcept C2780040984 @default.
• W4377014483 hasConcept C2780350126 @default.
• W4377014483 hasConcept C2780714102 @default.
• W4377014483 hasConcept C61511704 @default.
• W4377014483 hasConcept C71924100 @default.
• W4377014483 hasConcept C78085059 @default.
• W4377014483 hasConceptScore W4377014483C119060515 @default.
• W4377014483 hasConceptScore W4377014483C120665830 @default.
• W4377014483 hasConceptScore W4377014483C121332964 @default.
• W4377014483 hasConceptScore W4377014483C126322002 @default.
• W4377014483 hasConceptScore W4377014483C164705383 @default.
• W4377014483 hasConceptScore W4377014483C2778198053 @default.
• W4377014483 hasConceptScore W4377014483C2780007028 @default.
• W4377014483 hasConceptScore W4377014483C2780026749 @default.
• W4377014483 hasConceptScore W4377014483C2780040984 @default.
• W4377014483 hasConceptScore W4377014483C2780350126 @default.
• W4377014483 hasConceptScore W4377014483C2780714102 @default.
• W4377014483 hasConceptScore W4377014483C61511704 @default.
• W4377014483 hasConceptScore W4377014483C71924100 @default.
• W4377014483 hasConceptScore W4377014483C78085059 @default.
• W4377014483 hasIssue "5" @default.
• W4377014483 hasLocation W43770144831 @default.
• W4377014483 hasOpenAccess W4377014483 @default.
• W4377014483 hasPrimaryLocation W43770144831 @default.
• W4377014483 hasRelatedWork W1980849259 @default.
• W4377014483 hasRelatedWork W2184353247 @default.
• W4377014483 hasRelatedWork W2394784933 @default.
• W4377014483 hasRelatedWork W2469815070 @default.
• W4377014483 hasRelatedWork W2736002100 @default.
• W4377014483 hasRelatedWork W2913440745 @default.
• W4377014483 hasRelatedWork W2920644863 @default.
• W4377014483 hasRelatedWork W2999204693 @default.
• W4377014483 hasRelatedWork W3203530546 @default.
• W4377014483 hasRelatedWork W4317390639 @default.
• W4377014483 hasVolume "20" @default.
• W4377014483 isParatext "false" @default.
• W4377014483 isRetracted "false" @default.
• W4377014483 workType "article" @default.