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- W4377014592 abstract "Pharmacological therapy targeted at heart rate control reduces symptoms and hospitalizations in patients with permanent atrial fibrillation (AF). Contemporary agents achieve rate reduction by slowing conduction through the atrioventricular (AV) node. 1 Wyse D.G. Waldo A.L. DiMarco J.P. et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002; 347: 1825-1833 Crossref PubMed Google Scholar ,2 Kanagaratnam L. Kowey P. Whalley D. Pharmacological therapy for rate and rhythm control for atrial fibrillation in 2017. Heart Lung Circ. 2017; 26926-933 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar Beta-adrenergic antagonists, nondihydropyridine calcium channel blockers, and digoxin are the main classes of agents commonly used. The first 2 types are limited by negative inotropic actions, whereas digoxin has a narrow therapeutic range and is associated with increased morbidity and mortality with long-term administration. 3 Turakhia M.P. Santangeli P. Winkelmayer W.C. et al. Increased mortality associated with digoxin in contemporary patients with atrial fibrillation: findings from the TREAT-AF study. J Am Coll Cardiol. 2014; 64: 660-668 Crossref PubMed Scopus (167) Google Scholar Ivabradine for controlling heart rate in permanent atrial fibrillation: A translational clinical trialHeart RhythmVol. 20Issue 6PreviewPharmacological options for rate control in atrial fibrillation are scarce. Ivabradine was postulated to reduce the ventricular rate in this setting. Full-Text PDF" @default.
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- W4377014592 date "2023-06-01" @default.
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- W4377014592 title "Is inhibition of If in the atrioventricular node to control ventricular rate during atrial fibrillation ready for prime time?" @default.
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- W4377014592 doi "https://doi.org/10.1016/j.hrthm.2023.02.032" @default.
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