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- W4377014956 abstract "In this issue of the JAAD, Muntyanu et al discuss the association between organic solvent exposure and scleroderma. Patients were considered exposed if they self-reported exposures to chlorinated (eg, vinyl chloride, trichloroethylene, and dry cleaning solutions) and aromatic solvents (eg, toluene, benzene, and paint thinners/removers). Multivariate regression analysis suggested association between exposure and a higher risk of renal crisis and severe gastrointestinal disease and a nonstatistically significant trend toward diffuse systemic sclerosis, higher antitopoisomerase, and lower anticentromere antibodies. Organic solvent exposure and systemic sclerosis: A retrospective cohort study based on the Canadian Scleroderma Research Group registryJournal of the American Academy of DermatologyPreviewSystemic sclerosis (SSc) is a fibrosing systemic autoimmune rheumatic disease, hypothesized to be triggered by external factors in genetically predisposed individuals.1,2 Although occupational exposure to silica is a well-established risk factor for SSc development/severity, data on organic solvents (OSs), and impact on SSc disease phenotype are scarce.1,2 Full-Text PDF" @default.
- W4377014956 created "2023-05-19" @default.
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- W4377014956 date "2023-05-01" @default.
- W4377014956 modified "2023-10-18" @default.
- W4377014956 title "Letter from the Editor: Chemical exposure and sclerosing disorders" @default.
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- W4377014956 doi "https://doi.org/10.1016/j.jaad.2023.05.026" @default.
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