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- W4377015218 abstract "INTRODUCTION: Recent studies show that COVID has been associated with liver injury. Our study presents a case series of pregnant patients with intrahepatic cholestasis of pregnancy (ICP) complicated by prior COVID infection. METHODS: A retrospective review of singleton pregnancies delivered in an academic center between January 2020 and April 2022 identified patients with ICP (bile acids [BA]>10 mmol/L) with prior COVID infection in pregnancy. Maternal demographics, clinical/laboratory findings, medication use, and perinatal outcomes were collected. Secondary outcomes included BA greater than 40 mmol/L, BA trends in pregnancy, use of ursodiol, and rate of adverse perinatal outcomes (maternal/neonatal death). Institutional review board approval was exempted for this study. RESULTS: Of 138 cases of ICP and 743 cases of COVID during our study period, 14 patients were evaluated, 9 of whom met inclusion criteria. All cases of COVID resolved prior to delivery except one. Most cases (77.8%, 7/9) used ursodiol for treatment of ICP with mean duration of 6.9 weeks (±4.7). Six cases (66.7%) had BA greater than 40 mmol/L. One reported BA as high as 153 mmol/L at 23.5 weeks after COVID was diagnosed at 23.2 weeks. In this case, BA levels resolved by 26 weeks to less than 10 mmol/L and remained normal until delivery at 37 weeks. No adverse perinatal outcomes were reported. CONCLUSION: ICP cases in the setting of prior COVID in pregnancy are rare, but liver injury related to COVID may increase BA levels in pregnancy. Further studies are needed to evaluate possible associations between elevated BA due to COVID-19 and adverse perinatal outcomes." @default.
- W4377015218 created "2023-05-19" @default.
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- W4377015218 date "2023-05-01" @default.
- W4377015218 modified "2023-10-18" @default.
- W4377015218 title "Intrahepatic Cholestasis of Pregnancy Complicated by COVID-19 Infection [ID: 1381429]" @default.
- W4377015218 doi "https://doi.org/10.1097/01.aog.0000930156.34193.45" @default.
- W4377015218 hasPublicationYear "2023" @default.
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