FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377015330> ?p ?o ?g. }

• W4377015330 endingPage "S25" @default.
• W4377015330 startingPage "S25" @default.
• W4377015330 abstract "Amongst patients with left ventricular systolic dysfunction and prolonged QRS, cardiac resynchronisation therapy (CRT) can improve cardiac electrical/mechanical synchrony, and prevent adverse clinical outcomes. The baseline QRS duration is associated with improved response to CRT. However, the association between QRS narrowing after implantation and clinical response to CRT is unclear. To determine whether the degree of QRS narrowing is associated with clinical outcome following CRT implantation. The RAFT study enrolled 1798 patients with left ventricular ejection fraction (LVEF) ≤35%, QRS duration ≥120 ms and NYHA II-III to CRT-D or ICD. 894 were randomized to CRT-D of which 821 patients received CRT-D and had electrocardiograms (ECGs) available for review. The degree of QRS narrowing (dQRS) was calculated as the difference between baseline QRS duration and the widest QRS with CRT pacing post implantation. The primary outcome was a composite of death and heart failure hospitalisation. Multivariable Cox proportional hazards models were performed to assess the association between dQRS and the incidence of the primary composite outcome. To model the variation in risk of the outcome by dQRS, a restricted cubic spline function was used. The median age was 67 (IQR 59-73) years, 125 patients (15.2%) were women, median LVEF 24%, 68% had ischemic heart disease and 30% had atrial fibrillation. The baseline median QRS duration was 160 (IQR 140-178.5) ms, 68% had a left bundle branch block (LBBB). The median dQRS was 2 ms (IQR -18-20 ms), and 450 (55%) of patients had QRS narrowing post CRT. dQRS was associated with a reduction in the composite outcome (HR = 0.988, 95% CI 0.984-0.993), all-cause mortality (HR = 0.990, 95% CI 0.984-0.995) and heart failure hospitalisation (HR 0.990, 95% CI 0.985-0.997) in patients with CRT, following adjustment for age, sex, non-ischaemic cardiomyopathy, LVEF, atrial fibrillation/flutter, NHYA class, and peripheral vascular disease (Figure 1A). Similar findings were seen in the group without LBBB at baseline (HR 0.992, 95% CI 0.985-0.999) (Figure 1B). Amongst patients receiving CRT for left ventricular systolic dysfunction with QRS prolongation, any degree of QRS narrowing was found to be associated with an increasing reduction in mortality and heart failure, irrespective of the QRS morphology at baseline. This finding may improve outcomes in patients undergoing CRT implantation, particularly in those with a non-LBBB QRS morphology." @default.
• W4377015330 created "2023-05-19" @default.
• W4377015330 creator A5018203515 @default.
• W4377015330 creator A5035644440 @default.
• W4377015330 creator A5039188388 @default.
• W4377015330 creator A5057344499 @default.
• W4377015330 creator A5064130278 @default.
• W4377015330 creator A5078344915 @default.
• W4377015330 creator A5087964060 @default.
• W4377015330 creator A5091971699 @default.
• W4377015330 date "2023-05-01" @default.
• W4377015330 modified "2023-10-10" @default.
• W4377015330 title "CI-452767-1 THE ASSOCIATION BETWEEN QRS NARROWING WITH CARDIAC RESYNCHRONIZATION THERAPY, MORTALITY AND HEART FAILURE: A POST-HOC ANALYSIS OF THE RESYNCHRONIZATION IN AMBULATORY HEART FAILURE TRIAL (RAFT)" @default.
• W4377015330 doi "https://doi.org/10.1016/j.hrthm.2023.03.249" @default.
• W4377015330 hasPublicationYear "2023" @default.
• W4377015330 type Work @default.
• W4377015330 citedByCount "0" @default.
• W4377015330 crossrefType "journal-article" @default.
• W4377015330 hasAuthorship W4377015330A5018203515 @default.
• W4377015330 hasAuthorship W4377015330A5035644440 @default.
• W4377015330 hasAuthorship W4377015330A5039188388 @default.
• W4377015330 hasAuthorship W4377015330A5057344499 @default.
• W4377015330 hasAuthorship W4377015330A5064130278 @default.
• W4377015330 hasAuthorship W4377015330A5078344915 @default.
• W4377015330 hasAuthorship W4377015330A5087964060 @default.
• W4377015330 hasAuthorship W4377015330A5091971699 @default.
• W4377015330 hasBestOaLocation W43770153301 @default.
• W4377015330 hasConcept C111773187 @default.
• W4377015330 hasConcept C126322002 @default.
• W4377015330 hasConcept C164705383 @default.
• W4377015330 hasConcept C2776034619 @default.
• W4377015330 hasConcept C2777233412 @default.
• W4377015330 hasConcept C2777473070 @default.
• W4377015330 hasConcept C2778198053 @default.
• W4377015330 hasConcept C2779161974 @default.
• W4377015330 hasConcept C2780040984 @default.
• W4377015330 hasConcept C71924100 @default.
• W4377015330 hasConcept C78085059 @default.
• W4377015330 hasConceptScore W4377015330C111773187 @default.
• W4377015330 hasConceptScore W4377015330C126322002 @default.
• W4377015330 hasConceptScore W4377015330C164705383 @default.
• W4377015330 hasConceptScore W4377015330C2776034619 @default.
• W4377015330 hasConceptScore W4377015330C2777233412 @default.
• W4377015330 hasConceptScore W4377015330C2777473070 @default.
• W4377015330 hasConceptScore W4377015330C2778198053 @default.
• W4377015330 hasConceptScore W4377015330C2779161974 @default.
• W4377015330 hasConceptScore W4377015330C2780040984 @default.
• W4377015330 hasConceptScore W4377015330C71924100 @default.
• W4377015330 hasConceptScore W4377015330C78085059 @default.
• W4377015330 hasIssue "5" @default.
• W4377015330 hasLocation W43770153301 @default.
• W4377015330 hasOpenAccess W4377015330 @default.
• W4377015330 hasPrimaryLocation W43770153301 @default.
• W4377015330 hasRelatedWork W2010312933 @default.
• W4377015330 hasRelatedWork W2082998340 @default.
• W4377015330 hasRelatedWork W2350453664 @default.
• W4377015330 hasRelatedWork W2418986541 @default.
• W4377015330 hasRelatedWork W2441933436 @default.
• W4377015330 hasRelatedWork W2469815070 @default.
• W4377015330 hasRelatedWork W2999204693 @default.
• W4377015330 hasRelatedWork W3015833594 @default.
• W4377015330 hasRelatedWork W4293037456 @default.
• W4377015330 hasRelatedWork W4315784592 @default.
• W4377015330 hasVolume "20" @default.
• W4377015330 isParatext "false" @default.
• W4377015330 isRetracted "false" @default.
• W4377015330 workType "article" @default.