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- W4377015420 abstract "Catheter ablation (CA) is an effective and safe strategy for treating atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM). We investigated the electrophysiological characteristics of recurrence at a tertiary referral center and compared the long-term clinical outcomes after CA therapy with patients who did not receive CA. Patients with HCM and AF who underwent CA (group 1, n=60) or pharmacological treatment (group 2, n=298) from 2006 to 2021 were enrolled. The patients’ baseline characteristics and electrophysiological features were examined to elucidate the reason for AF recurrence after CA in part I of the study (group 1). The clinical outcomes of group 1 and group 2 patients were compared using a propensity score (PS)-matched method in part II. In part I, the most common cause of recurrence was pulmonary vein (PV) reconnection (86.5%), followed by non-PV triggers (40.5%), cavotricuspid isthmus flutter (29.7%), and atypical flutter (24.3%). Thyroid disease (HR: 14.713, p<0.001), diabetes (HR: 3.074, p=0.034), and non-paroxysmal AF (HR: 4.012, p=0.007) independently predicted recurrence. After the first recurrence, the patients who underwent repeat CA demonstrated better arrhythmia-free status (74.1%) compared to those who underwent drug-escalation therapy (29.4%, p=0.004). In part II, after matching, PS-group 1 patients had significantly better outcomes in all-cause mortality, heart failure hospitalization, and left atrium reverse remodeling than PS-group 2 patients. Patients who underwent CA had better clinical outcomes than those who did not receive CA. The main recurrence predictors were thyroid disease, diabetes, and non-paroxysmal AF." @default.
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- W4377015420 date "2023-05-01" @default.
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- W4377015420 title "AB-452666-3 CATHETER ABLATION IN ASIAN PATIENTS WITH ATRIAL FIBRILLATION AND HYPERTROPHIC CARDIOMYOPATHY: ELECTROPHYSIOLOGICAL CHARACTERISTICS OF RECURRENCE AND LONG-TERM CLINICAL OUTCOMES" @default.
- W4377015420 doi "https://doi.org/10.1016/j.hrthm.2023.03.1534" @default.
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