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• W4377015540 abstract "PVC burden frequency has been shown to correlate with the incidence of PVC-mediated cardiomyopathy. A single center study of 107 patients wearing Zio monitors indicated that measurement of PVC burden for 24-48 hours may not reflect the total burden. This study aims to assess PVC burden density, and the significance of long-term monitoring in a large national cohort. The objective of this study is to establish the optimal duration of ECG monitoring required to accurately characterize PVC burden severity and other significant factors. Patients with a PVC burden ≥5%, age ≥18 and a ≥13-day wear period were analyzed between June 2011 to April 2022. Patient demographics were reported, and the mean absolute error in PVC burden was calculated at baseline (<10 sec), 24 hours, 48 hours, and daily to14 days. Burden at the end of the wear period was considered the true value for PVC burden. The measured error was described for each subinterval (mean, SD, median, IQR). The accuracy in PVC burden was evaluated across monitoring durations at 10% (low),15% (moderate) and 20% (high) thresholds. There were 106,705 patients analyzed, 33.6% of patients were females with an average age of 67.3±15.4 years old. PVC density was more frequent in males than females, 66:34 respectively and in those older than 65 years of age. The PVC burden mean absolute error was calculated at baseline (<10sec), 24 hours, 48 hours, 7 days, and 13 days (Figure1). When comparing PVC burden densities with lower and higher than 20% at 24 hours and 7 days, data showed a decreased in mean absolute error from 2.78% and 3.97% at 24 hours to 1.27% and 1.75% at 7 days. Furthermore, the accuracy in categorization of PVC burden at 15% threshold increased from 89.2% at 24 hours to 95.1% at 7 days. Most common concerning arrhythmias detected in patients with PVC burden do show important delineating trend to consider (Table1). In this large national cohort, the reduction in PVC burden mean absolute error from 24 hours through 14 days underscores the importance of long-term ambulatory monitoring and extends prior study results. Increased monitoring duration through at least 7-10 days is associated with improved accuracy in categorization of patients by PVC burden level. Patients with PVC burden <20% may benefit from longer monitoring compared to >20% burden population. Concomitant arrythmias including VT and Afib in patient with PVC burden further emphasized the significance of closer monitoring and early detection.Tabled 1Table1Total Device Count (%)Low (5%-10%)* n=59,702Moderate(10%-20%)* n=34,605High (>20%)* n=12,398Overall* n=106,705VT37,858 (63.4)23,799 (68.8)9,251 (74.6)70,908 (66.5)AFIB9,021 (15.1)4,123 (11.9)1,119 (9.0)14,263 (13.4)SVT46,068 (77.2)26,712 (77.2)9,495 (76.6)82,275 (77.1)AVB1,467 (2.5)671 (1.9)181 (1.5)2,319 (2.2)Pause (≥3 sec)3,479 (5.8)1,682 (4.9)466 (3.8)5,627 (5.3) Open table in a new tab" @default.
• W4377015540 created "2023-05-19" @default.
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• W4377015540 date "2023-05-01" @default.
• W4377015540 modified "2023-09-27" @default.
• W4377015540 title "PO-04-188 PREMATURE VENTRICULAR COMPLEXES: ASSESSING BURDEN DENSITY IN A LARGE NATIONAL COHORT POPULATION TO BETTER DEFINE OPTIMAL ECG MONITORING DURATION" @default.
• W4377015540 doi "https://doi.org/10.1016/j.hrthm.2023.03.1204" @default.
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