FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377015571> ?p ?o ?g. }

• W4377015571 endingPage "S405" @default.
• W4377015571 startingPage "S405" @default.
• W4377015571 abstract "Sudden cardiac death (SCD) remains a major public health problem. Severe left ventricular (LV) dysfunction (EF ≤ 35%) increases the risk of SCD and is the most important indication for prophylactic implantable cardioverter defibrillator (ICD). Previous studies have shown that subjects with EF ≤ 35% represent a minority of all SCD cases. However, it has been unclear whether ischemic and nonischemic cardiac diseases present with different LVEF prior to SCD. We sought to evaluate the spectrum of LVEF among SCD victims with ischemic and nonischemic etiologies. Our study population is drawn from the Fingesture study, which has prospectively collected autopsy and clinical data from consecutive SCD victims from Northern Finland between 1998 and 2017. The cause of death was verified to be of cardiac origin in a medicolegal autopsy in all cases. Cases with ischemic SCD had evidence of coronary artery disease and ischemic cardiomyopathy at autopsy. Electronic health records were examined to identify subjects who underwent evaluation for LV function before SCD. LV function was categorized by quantitative assessment of LVEF as normal (EF ≥ 50%), reduced (50% > EF > 35%), and severely reduced (EF ≤ 35%). In all cases, echocardiography was unrelated to the SCD event. Left ventricular assessment was available in 717 SCD victims. The majority of subjects (n=449, 62.7%) had normal LVEF prior to SCD. The prevalence of reduced LVEF was 21.9%, while severely reduced LVEF was found only in 110 subjects (15.4%). Men were more likely to have LV dysfunction than women (45.9% vs 29.6%; p<0.001). In addition, LVEF was found to be severely reduced more commonly in men compared to women (17.4% vs 10.9% respectively; p<0.001). In SCD victims with ischemic and nonischemic heart disease, LV dysfunction was equally common (37.7% vs 36% respectively; p=0.72). The prevalence of severely reduced LVEF was also similar between ischemic SCD and nonischemic SCD (15.1% vs. 16.3%, respectively; p=0.72). Only one third of SCD cases had ventricular dysfunction and only one in seven had severely reduced LVEF prior to their SCD event, suggesting that only a minority of SCD victims meet the current criteria for primary prevention ICD. We found no difference in the spectrum of LVEF between ischemic and nonischemic heart diseases. However, women were found to have preserved LV function more often than men, highlighting the importance of developing novel SCD risk stratification tools beyond LVEF." @default.
• W4377015571 created "2023-05-19" @default.
• W4377015571 creator A5028723432 @default.
• W4377015571 creator A5053247564 @default.
• W4377015571 creator A5059861456 @default.
• W4377015571 date "2023-05-01" @default.
• W4377015571 modified "2023-10-16" @default.
• W4377015571 title "PO-03-230 LEFT VENTRICULAR FUNCTION IN SUDDEN CARDIAC DEATH DUE TO ISCHEMIC AND NONISCHEMIC HEART DISEASE" @default.
• W4377015571 doi "https://doi.org/10.1016/j.hrthm.2023.03.910" @default.
• W4377015571 hasPublicationYear "2023" @default.
• W4377015571 type Work @default.
• W4377015571 citedByCount "0" @default.
• W4377015571 crossrefType "journal-article" @default.
• W4377015571 hasAuthorship W4377015571A5028723432 @default.
• W4377015571 hasAuthorship W4377015571A5053247564 @default.
• W4377015571 hasAuthorship W4377015571A5059861456 @default.
• W4377015571 hasBestOaLocation W43770155711 @default.
• W4377015571 hasConcept C126322002 @default.
• W4377015571 hasConcept C164705383 @default.
• W4377015571 hasConcept C2775932942 @default.
• W4377015571 hasConcept C2775935837 @default.
• W4377015571 hasConcept C2777093960 @default.
• W4377015571 hasConcept C2778198053 @default.
• W4377015571 hasConcept C2778213512 @default.
• W4377015571 hasConcept C2778797674 @default.
• W4377015571 hasConcept C2779134260 @default.
• W4377015571 hasConcept C2779504383 @default.
• W4377015571 hasConcept C2908647359 @default.
• W4377015571 hasConcept C29374701 @default.
• W4377015571 hasConcept C2993353509 @default.
• W4377015571 hasConcept C71924100 @default.
• W4377015571 hasConcept C78085059 @default.
• W4377015571 hasConcept C99454951 @default.
• W4377015571 hasConceptScore W4377015571C126322002 @default.
• W4377015571 hasConceptScore W4377015571C164705383 @default.
• W4377015571 hasConceptScore W4377015571C2775932942 @default.
• W4377015571 hasConceptScore W4377015571C2775935837 @default.
• W4377015571 hasConceptScore W4377015571C2777093960 @default.
• W4377015571 hasConceptScore W4377015571C2778198053 @default.
• W4377015571 hasConceptScore W4377015571C2778213512 @default.
• W4377015571 hasConceptScore W4377015571C2778797674 @default.
• W4377015571 hasConceptScore W4377015571C2779134260 @default.
• W4377015571 hasConceptScore W4377015571C2779504383 @default.
• W4377015571 hasConceptScore W4377015571C2908647359 @default.
• W4377015571 hasConceptScore W4377015571C29374701 @default.
• W4377015571 hasConceptScore W4377015571C2993353509 @default.
• W4377015571 hasConceptScore W4377015571C71924100 @default.
• W4377015571 hasConceptScore W4377015571C78085059 @default.
• W4377015571 hasConceptScore W4377015571C99454951 @default.
• W4377015571 hasIssue "5" @default.
• W4377015571 hasLocation W43770155711 @default.
• W4377015571 hasOpenAccess W4377015571 @default.
• W4377015571 hasPrimaryLocation W43770155711 @default.
• W4377015571 hasRelatedWork W1971300170 @default.
• W4377015571 hasRelatedWork W2104371670 @default.
• W4377015571 hasRelatedWork W2167036398 @default.
• W4377015571 hasRelatedWork W2377979999 @default.
• W4377015571 hasRelatedWork W2751442347 @default.
• W4377015571 hasRelatedWork W2896445697 @default.
• W4377015571 hasRelatedWork W2964563167 @default.
• W4377015571 hasRelatedWork W3130881448 @default.
• W4377015571 hasRelatedWork W3186131889 @default.
• W4377015571 hasRelatedWork W4221035049 @default.
• W4377015571 hasVolume "20" @default.
• W4377015571 isParatext "false" @default.
• W4377015571 isRetracted "false" @default.
• W4377015571 workType "article" @default.