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- W4377015655 abstract "Implantable cardioverter defibrillator (ICD) replacement in patients with heart failure with improved ejection fraction (HFimpEF, EF>35%) at the time of generator change is controversial. Assess the risk of appropriate ICD intervention (aICDi, anti-tachycardia pacing or shocks) in patients with HFimpEF >35%. Databases were searched for studies reporting patients who received ICD for primary prevention and HFimpEF, and aICDi including Ovid MEDLINE, EMBASE, Web of Science, and Google Scholar. The search was not restricted to time or publication status. The minimal follow up duration was one year. HFimpEF was defined as left ventricular reversed remodeling (LVRR, see Figures) with EF >35%. A total of 25 studies and 6,452 patients (3,061 with improved EF vs 3,391 with EF <35% during follow up) were included; mean follow up was 43 months (ranging between 12 to 74 months). Mean age was 63.5 and 75% were males. HFimpEF was associated with a lower risk of aICDi (OR 0.43, 95% CI 0.3-0.61; P<0.01; annual rate 5.1 vs. 10.3%). Subgroup analysis in HFimpEF patients who had not received aICDi before generator change showed a lower subsequent risk of VA and SCD (OR 0.26, 95% CI 0.12-0.59; P<0.01; annual rate 1.6 vs. 4.8%). Figures (A, B) HFimpEF is associated with reduced risk for aICDi in patients with primary prevention ICDs. HFimpEF patients who had not received aICDi before generator change had even lower subsequent risk, but the 5-year risk of arrhythmia recurrence is still 8%." @default.
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- W4377015655 date "2023-05-01" @default.
- W4377015655 modified "2023-09-27" @default.
- W4377015655 title "PO-05-203 RISK OF APPROPRIATE ICD THERAPY IN PATIENTS WITH IMPROVED EF>35% AFTER INITIAL PRIMARY PREVENTION IMPLANT" @default.
- W4377015655 doi "https://doi.org/10.1016/j.hrthm.2023.03.1406" @default.
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