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- W4377015870 abstract "The prevailing view of metazoan gene regulation is that transcription is facilitated through the formation of static activator complexes at distal regulatory regions. Here, we employed quantitative single-cell live-imaging and computational analysis to provide evidence that the dynamic assembly and disassembly process of transcription factor (TF) clusters at enhancers is a major source of transcriptional bursting in developing Drosophila embryos. We further show that the regulatory connectivity between TF clustering and burst induction is highly regulated through intrinsically disordered regions (IDRs). Addition of a poly-glutamine tract to the maternal morphogen Bicoid demonstrated that extended IDR length leads to ectopic TF clustering and burst induction from its endogenous target genes, resulting in defects in body segmentation during embryogenesis. Moreover, we successfully visualized the presence of shared TF clusters during the co-activation of two distant genes, which provides a concrete molecular explanation for the newly proposed topological operon hypothesis in metazoan gene regulation." @default.
- W4377015870 created "2023-05-19" @default.
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- W4377015870 date "2023-05-01" @default.
- W4377015870 modified "2023-10-14" @default.
- W4377015870 title "Functional coordination between transcription factor clustering and gene activity" @default.
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- W4377015870 doi "https://doi.org/10.1016/j.molcel.2023.04.018" @default.
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