FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377015977> ?p ?o ?g. }

• W4377015977 endingPage "S357" @default.
• W4377015977 startingPage "S357" @default.
• W4377015977 abstract "Multiple studies have reported that female gender is predictive of positive response to cardiac resynchronization therapy (CRT). However, the mechanisms underlying this association remain unclear. We aimed to examine the association between gender and echocardiographic CRT response (reduction in LV end systolic volume (LVESV) >15% at 6 months), in patients recruited to the MORE-CRT MPP study. MORE-CRT MPP is a prospective, randomized, multicenter study. All patients initially receive conventional biventricular (BiV) CRT for 6 months. At this stage, echocardiographic non-responders are randomized to either continued conventional BiV pacing, or MultiPoint pacing. This post-hoc analysis examined predictors of initial response to 6 months of BiV pacing only. We performed univariable models using baseline variables. Multivariable models were conducted using stepwise model selections (n = 2,866). The criteria for baseline variables entering and staying into model was α=0.25 and α=0.05, respectively. Age and gender were forced into the model. Of 3739 patients in the analysis, 28% were female. The cardiac size in females was significantly smaller compared to males (175.8±60.3ml vs. 228.3±76.9ml, p<0.0001). Males had a significantly broader QRSd than females (157.7±26.1ms vs. 152.3±22.1ms, p<0.0001). The logistic regression model showed that: no history of AF, non-ischemic aetiology, left bundle branch block (LBBB), smaller heart (↓LVEDV), wide QRSd, no history of renal disease, and female gender are significant independent predictors for CRT response (see table). In a separate model, QRSd/LVEDV ratio was a significant response predictor in a univariable analysis, but not in multivariable analysis with gender included in the model (OR 1.21 95% CI 0.89-1.63, p=0.22). Female gender is a significant predictor of superior CRT response. This association is independent from variables including: AF, aetiology, LBBB and QRSd. However, QRSd/LVEDV, a ratio measuring dyssynchrony relative to heart size, was not independently predictive of response when gender is included in the multivariable analysis. This suggests that the female superiority of CRT response may be related to a higher degree of relative dyssynchrony (higher QRSd/LVEDV ratio). Female patients may benefit from a lower QRSd cut-off when considering their suitability for CRT, based on a smaller heart size, and thus a higher degree of relative dyssynchrony at a given QRSd." @default.
• W4377015977 created "2023-05-19" @default.
• W4377015977 creator A5000435552 @default.
• W4377015977 creator A5015045005 @default.
• W4377015977 creator A5016734550 @default.
• W4377015977 creator A5022133771 @default.
• W4377015977 creator A5022643558 @default.
• W4377015977 creator A5023712545 @default.
• W4377015977 creator A5030474533 @default.
• W4377015977 creator A5030900639 @default.
• W4377015977 creator A5057844452 @default.
• W4377015977 creator A5067661291 @default.
• W4377015977 creator A5071185821 @default.
• W4377015977 creator A5071530424 @default.
• W4377015977 date "2023-05-01" @default.
• W4377015977 modified "2023-10-09" @default.
• W4377015977 title "PO-02-015 THE IMPACT OF GENDER AND LV SIZE ON CARDIAC RESYNCHRONIZATION THERAPY RESPONSE" @default.
• W4377015977 doi "https://doi.org/10.1016/j.hrthm.2023.03.821" @default.
• W4377015977 hasPublicationYear "2023" @default.
• W4377015977 type Work @default.
• W4377015977 citedByCount "0" @default.
• W4377015977 crossrefType "journal-article" @default.
• W4377015977 hasAuthorship W4377015977A5000435552 @default.
• W4377015977 hasAuthorship W4377015977A5015045005 @default.
• W4377015977 hasAuthorship W4377015977A5016734550 @default.
• W4377015977 hasAuthorship W4377015977A5022133771 @default.
• W4377015977 hasAuthorship W4377015977A5022643558 @default.
• W4377015977 hasAuthorship W4377015977A5023712545 @default.
• W4377015977 hasAuthorship W4377015977A5030474533 @default.
• W4377015977 hasAuthorship W4377015977A5030900639 @default.
• W4377015977 hasAuthorship W4377015977A5057844452 @default.
• W4377015977 hasAuthorship W4377015977A5067661291 @default.
• W4377015977 hasAuthorship W4377015977A5071185821 @default.
• W4377015977 hasAuthorship W4377015977A5071530424 @default.
• W4377015977 hasBestOaLocation W43770159771 @default.
• W4377015977 hasConcept C126322002 @default.
• W4377015977 hasConcept C151956035 @default.
• W4377015977 hasConcept C164705383 @default.
• W4377015977 hasConcept C168563851 @default.
• W4377015977 hasConcept C2776034619 @default.
• W4377015977 hasConcept C2777473070 @default.
• W4377015977 hasConcept C2778198053 @default.
• W4377015977 hasConcept C67761136 @default.
• W4377015977 hasConcept C71924100 @default.
• W4377015977 hasConcept C77350462 @default.
• W4377015977 hasConcept C78085059 @default.
• W4377015977 hasConceptScore W4377015977C126322002 @default.
• W4377015977 hasConceptScore W4377015977C151956035 @default.
• W4377015977 hasConceptScore W4377015977C164705383 @default.
• W4377015977 hasConceptScore W4377015977C168563851 @default.
• W4377015977 hasConceptScore W4377015977C2776034619 @default.
• W4377015977 hasConceptScore W4377015977C2777473070 @default.
• W4377015977 hasConceptScore W4377015977C2778198053 @default.
• W4377015977 hasConceptScore W4377015977C67761136 @default.
• W4377015977 hasConceptScore W4377015977C71924100 @default.
• W4377015977 hasConceptScore W4377015977C77350462 @default.
• W4377015977 hasConceptScore W4377015977C78085059 @default.
• W4377015977 hasIssue "5" @default.
• W4377015977 hasLocation W43770159771 @default.
• W4377015977 hasOpenAccess W4377015977 @default.
• W4377015977 hasPrimaryLocation W43770159771 @default.
• W4377015977 hasRelatedWork W2067788052 @default.
• W4377015977 hasRelatedWork W2350453664 @default.
• W4377015977 hasRelatedWork W2382547358 @default.
• W4377015977 hasRelatedWork W2587855402 @default.
• W4377015977 hasRelatedWork W2915561147 @default.
• W4377015977 hasRelatedWork W2999204693 @default.
• W4377015977 hasRelatedWork W3031164927 @default.
• W4377015977 hasRelatedWork W3032016155 @default.
• W4377015977 hasRelatedWork W4293037456 @default.
• W4377015977 hasRelatedWork W4315784592 @default.
• W4377015977 hasVolume "20" @default.
• W4377015977 isParatext "false" @default.
• W4377015977 isRetracted "false" @default.
• W4377015977 workType "article" @default.