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• W4377016021 abstract "Mapping arrhythmias and concretely atrial fibrillation (AF) is complicated by our inability to determine local from far field electrograms, as far field interfere with the identification of local activity in the specific electrode location. In particular, how “local” is local field on any specific electrode and catheter is not yet biophysically defined. We tested the hypothesis that EGM conformation on specific electrode configurations can be explained by modelling the biophysical relation between the electrode size and separation in active myocardial tissue. We modelled laminar conduction in atrial tissue of 30x30x3 mm on a 1 mm electrode, discretized into 100.000 and 100 nodes respectively (fig. A) and simulating propagation waves with constant propagation direction at different conduction velocities. The EGM was constructed using the electric potential transfer equation between the tissue and the electrode, and this equation was discretized for each tissue node to evaluate individual contributions of atrial regions to construct unipolar (fig B) and bipolar (fig C) EGM signals. This allowed to unify the near field definition for all types of electrodes as regions contributing at least 30% respect to the maximal tissue contribution. In Figure B, the unipolar electrode recorded near field from a circle of radius 8 mm endocardially, and 2.7 mm transmurally with a 1.9 ratio of endo-to-epicardial amplitude. Bipolar electrodes showed directional antennas for near field aligned with the propagation direction (fig. C) with radii of 1.7, 5.7 and 8.3 mm for 2, 5, and 10 mm spacing (fig. C). Bipolar electrodes showed less transmural variability on the near field antenna, from 2 to 2.7 mm (fig. D). These data show that local signals on clinical catheters can represent near field activity in 1.7 to ∼8 mm radius spheres. Studies are required to define optimal electrode configurations to map AF, ventricular fibrillation, atrial and ventricular tachycardia." @default.
• W4377016021 created "2023-05-19" @default.
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• W4377016021 date "2023-05-01" @default.
• W4377016021 modified "2023-09-30" @default.
• W4377016021 title "PO-03-096 DEFINING RECORDING ANTENNA FOR ATRIAL ELECTRODES BY ENDOCARDIAL AND EPICARDIAL COMPUTER MAPPING" @default.
• W4377016021 doi "https://doi.org/10.1016/j.hrthm.2023.03.1009" @default.
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