FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377016055> ?p ?o ?g. }

• W4377016055 endingPage "659" @default.
• W4377016055 startingPage "646" @default.
• W4377016055 abstract "Background Rome criteria differentiate distinct types of disorders of gut–brain interaction (DGBI); also known as functional gastrointestinal disorders. Overlap of symptom categories frequently occurs. This systematic review and meta-analysis aimed to define the prevalence of DGBI overlap and compare overlap in population-based, primary care or tertiary care health settings. Furthermore, we aimed to compare symptom severity of psychological comorbidities in DGBI with and without overlap. Methods For this systematic review and meta-analysis we searched MEDLINE (PubMed) and Embase electronic databases from inception until March 1, 2022, for original articles and conference abstracts of observational cross-sectional, case-controlled, or cohort design studies that reported the prevalence of DGBI overlap in adult participants (aged ≥18 years). We included only those studies where the diagnosis of DGBI was based on clinical assessment, questionnaire data, or specific symptom-based criteria. Studies were excluded if reporting on mixed populations of DGBI and organic diseases. Aggregate patient data were extracted from eligible published studies. The prevalence of DGBI overlap in all studies was pooled using the DerSimonian and Laird random effects model, and further analysis stratified by subgroups (care setting, diagnostic criteria, geographic region, and gross domestic product per capita). We also assessed the relationship between DGBI overlap with anxiety, depression, and quality of life symptom scores. This study was registered with PROSPERO (CRD42022311101). Findings 46 of 1268 screened studies, reporting on 75 682 adult DGBI participants, were eligible for inclusion in this systematic review and meta-analysis. Overall, 24 424 (pooled prevalence 36·5% [95% CI 30·7 to 42·6]) participants had a DGBI overlap, with considerable between-study heterogeneity (I2=99·51, p=0·0001). In the tertiary health-care setting, overlap among participants with DGBI was more prevalent (8373 of 22 617, pooled prevalence 47·3% [95% CI 33·2 to 61·7]) compared with population-based cohorts (11 332 of 39 749, pooled prevalence 26·5% [95% CI 20·5 to 33·4]; odds ratio 2·50 [95% CI 1·28 to 4·87]; p=0·0084). Quality of life physical component scores were significantly lower in participants with DGBI overlap compared with participants without overlap (standardised mean difference –0·47 [95% CI –0·80 to –0·14]; p=0·025). Participants with DGBI overlap had both increased symptom scores for anxiety (0·39 [95% CI 0·24 to 0·54]; p=0·0001) and depression (0·41 [0·30 to 0·51]; p=0·0001). Interpretation Overlap of DGBI subtypes is frequent, and is more prevalent in tertiary care settings and associated with more severe symptom manifestations or psychological comorbidities. Despite the large sample size, the comparative analyses revealed substantial heterogeneity, and the results should be interpreted with caution. Funding National Health and Medical Research Council and Centre for Research Excellence. Rome criteria differentiate distinct types of disorders of gut–brain interaction (DGBI); also known as functional gastrointestinal disorders. Overlap of symptom categories frequently occurs. This systematic review and meta-analysis aimed to define the prevalence of DGBI overlap and compare overlap in population-based, primary care or tertiary care health settings. Furthermore, we aimed to compare symptom severity of psychological comorbidities in DGBI with and without overlap. For this systematic review and meta-analysis we searched MEDLINE (PubMed) and Embase electronic databases from inception until March 1, 2022, for original articles and conference abstracts of observational cross-sectional, case-controlled, or cohort design studies that reported the prevalence of DGBI overlap in adult participants (aged ≥18 years). We included only those studies where the diagnosis of DGBI was based on clinical assessment, questionnaire data, or specific symptom-based criteria. Studies were excluded if reporting on mixed populations of DGBI and organic diseases. Aggregate patient data were extracted from eligible published studies. The prevalence of DGBI overlap in all studies was pooled using the DerSimonian and Laird random effects model, and further analysis stratified by subgroups (care setting, diagnostic criteria, geographic region, and gross domestic product per capita). We also assessed the relationship between DGBI overlap with anxiety, depression, and quality of life symptom scores. This study was registered with PROSPERO (CRD42022311101). 46 of 1268 screened studies, reporting on 75 682 adult DGBI participants, were eligible for inclusion in this systematic review and meta-analysis. Overall, 24 424 (pooled prevalence 36·5% [95% CI 30·7 to 42·6]) participants had a DGBI overlap, with considerable between-study heterogeneity (I2=99·51, p=0·0001). In the tertiary health-care setting, overlap among participants with DGBI was more prevalent (8373 of 22 617, pooled prevalence 47·3% [95% CI 33·2 to 61·7]) compared with population-based cohorts (11 332 of 39 749, pooled prevalence 26·5% [95% CI 20·5 to 33·4]; odds ratio 2·50 [95% CI 1·28 to 4·87]; p=0·0084). Quality of life physical component scores were significantly lower in participants with DGBI overlap compared with participants without overlap (standardised mean difference –0·47 [95% CI –0·80 to –0·14]; p=0·025). Participants with DGBI overlap had both increased symptom scores for anxiety (0·39 [95% CI 0·24 to 0·54]; p=0·0001) and depression (0·41 [0·30 to 0·51]; p=0·0001). Overlap of DGBI subtypes is frequent, and is more prevalent in tertiary care settings and associated with more severe symptom manifestations or psychological comorbidities. Despite the large sample size, the comparative analyses revealed substantial heterogeneity, and the results should be interpreted with caution." @default.
• W4377016055 created "2023-05-19" @default.
• W4377016055 creator A5019719568 @default.
• W4377016055 creator A5022374905 @default.
• W4377016055 creator A5027136649 @default.
• W4377016055 creator A5027207559 @default.
• W4377016055 creator A5034890420 @default.
• W4377016055 creator A5038282225 @default.
• W4377016055 creator A5044348871 @default.
• W4377016055 creator A5071291501 @default.
• W4377016055 creator A5072395146 @default.
• W4377016055 date "2023-07-01" @default.
• W4377016055 modified "2023-09-27" @default.
• W4377016055 title "Overlap of disorders of gut–brain interaction: a systematic review and meta-analysis" @default.
• W4377016055 cites W1527051923 @default.
• W4377016055 cites W1536123305 @default.
• W4377016055 cites W1561056507 @default.
• W4377016055 cites W1902819465 @default.
• W4377016055 cites W1967870652 @default.
• W4377016055 cites W1968423320 @default.
• W4377016055 cites W1969642144 @default.
• W4377016055 cites W1978004416 @default.
• W4377016055 cites W1987232009 @default.
• W4377016055 cites W1988429445 @default.
• W4377016055 cites W2003082629 @default.
• W4377016055 cites W2020502201 @default.
• W4377016055 cites W2021185007 @default.
• W4377016055 cites W2021734146 @default.
• W4377016055 cites W2032506622 @default.
• W4377016055 cites W2034563015 @default.
• W4377016055 cites W2034705777 @default.
• W4377016055 cites W2043705607 @default.
• W4377016055 cites W2043834013 @default.
• W4377016055 cites W2048250375 @default.
• W4377016055 cites W2064201279 @default.
• W4377016055 cites W2066972781 @default.
• W4377016055 cites W2070888548 @default.
• W4377016055 cites W2073886498 @default.
• W4377016055 cites W2074074377 @default.
• W4377016055 cites W2081132041 @default.
• W4377016055 cites W2081644869 @default.
• W4377016055 cites W2082138024 @default.
• W4377016055 cites W2083798047 @default.
• W4377016055 cites W2086146158 @default.
• W4377016055 cites W2086533758 @default.
• W4377016055 cites W2098965234 @default.
• W4377016055 cites W2110252178 @default.
• W4377016055 cites W2112778345 @default.
• W4377016055 cites W2123290920 @default.
• W4377016055 cites W2126930838 @default.
• W4377016055 cites W2129920713 @default.
• W4377016055 cites W2132322340 @default.
• W4377016055 cites W2136145129 @default.
• W4377016055 cites W2145379885 @default.
• W4377016055 cites W2146589073 @default.
• W4377016055 cites W2156059840 @default.
• W4377016055 cites W2156098321 @default.
• W4377016055 cites W2159172669 @default.
• W4377016055 cites W2166281097 @default.
• W4377016055 cites W2166650939 @default.
• W4377016055 cites W2281732682 @default.
• W4377016055 cites W2286726261 @default.
• W4377016055 cites W2344547018 @default.
• W4377016055 cites W2344997643 @default.
• W4377016055 cites W2411093617 @default.
• W4377016055 cites W2417616718 @default.
• W4377016055 cites W2568187864 @default.
• W4377016055 cites W2577452822 @default.
• W4377016055 cites W2579795023 @default.
• W4377016055 cites W2584273077 @default.
• W4377016055 cites W2594258223 @default.
• W4377016055 cites W2621555648 @default.
• W4377016055 cites W2768229082 @default.
• W4377016055 cites W2791544884 @default.
• W4377016055 cites W2793079911 @default.
• W4377016055 cites W2803348669 @default.
• W4377016055 cites W2803410130 @default.
• W4377016055 cites W2809108805 @default.
• W4377016055 cites W2898162003 @default.
• W4377016055 cites W2991792334 @default.
• W4377016055 cites W2997883869 @default.
• W4377016055 cites W3003379297 @default.
• W4377016055 cites W3016136018 @default.
• W4377016055 cites W3040516339 @default.
• W4377016055 cites W3086916858 @default.
• W4377016055 cites W3096862230 @default.
• W4377016055 cites W3105619193 @default.
• W4377016055 cites W3109981356 @default.
• W4377016055 cites W3122523307 @default.
• W4377016055 cites W3127726089 @default.
• W4377016055 cites W3133610049 @default.
• W4377016055 cites W3143243406 @default.
• W4377016055 cites W3149073198 @default.
• W4377016055 cites W3165813969 @default.
• W4377016055 cites W4238079920 @default.
• W4377016055 cites W4242426744 @default.
• W4377016055 cites W4249534836 @default.
• W4377016055 cites W4292806894 @default.

• next