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- W4377018114 abstract "Reactive oxygen species (ROS)-associated oxidative stress, inflammation storm, and massive hepatocyte necrosis are the typical manifestations of acute liver failure (ALF), therefore specific therapeutic interventions are essential for the devastating disease. Here, we developed a platform consisting of versatile biomimetic copper oxide nanozymes (Cu NZs)-loaded PLGA nanofibers (Cu NZs@PLGA nanofibers) and decellularized extracellular matrix (dECM) hydrogels for delivery of human adipose-derived mesenchymal stem/stromal cells-derived hepatocyte-like cells (hADMSCs-derived HLCs) (HLCs/Cu NZs@fiber/dECM). Cu NZs@PLGA nanofibers could conspicuously scavenge excessive ROS at the early stage of ALF, and reduce the massive accumulation of pro-inflammatory cytokines, herein efficiently preventing the deterioration of hepatocytes necrosis. Moreover, Cu NZs@PLGA nanofibers also exhibited a cytoprotection effect on the transplanted HLCs. Meanwhile, HLCs with hepatic-specific biofunctions and anti-inflammatory activity acted as a promising alternative cell source for ALF therapy. The dECM hydrogels further provided the desirable 3D environment and favorably improved the hepatic functions of HLCs. In addition, the pro-angiogenesis activity of Cu NZs@PLGA nanofibers also facilitated the integration of the whole implant with the host liver. Hence, HLCs/Cu NZs@fiber/dECM performed excellent synergistic therapeutic efficacy on ALF mice. This strategy using Cu NZs@PLGA nanofiber-reinforced dECM hydrogels for HLCs in situ delivery is a promising approach for ALF therapy and shows great potential for clinical translation." @default.
- W4377018114 created "2023-05-19" @default.
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- W4377018114 date "2023-10-01" @default.
- W4377018114 modified "2023-10-14" @default.
- W4377018114 title "Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure" @default.
- W4377018114 cites W1628437161 @default.
- W4377018114 cites W1967466647 @default.
- W4377018114 cites W1976652877 @default.
- W4377018114 cites W1990640161 @default.
- W4377018114 cites W2025966264 @default.
- W4377018114 cites W2026933993 @default.
- W4377018114 cites W2033335693 @default.
- W4377018114 cites W2081875195 @default.
- W4377018114 cites W2148173491 @default.
- W4377018114 cites W2154718179 @default.
- W4377018114 cites W2185108125 @default.
- W4377018114 cites W2291107594 @default.
- W4377018114 cites W2338909632 @default.
- W4377018114 cites W2510362766 @default.
- W4377018114 cites W2558163233 @default.
- W4377018114 cites W2609217537 @default.
- W4377018114 cites W2611604513 @default.
- W4377018114 cites W2618245525 @default.
- W4377018114 cites W2761926088 @default.
- W4377018114 cites W2764103451 @default.
- W4377018114 cites W2766677265 @default.
- W4377018114 cites W2766756220 @default.
- W4377018114 cites W2779261498 @default.
- W4377018114 cites W2784250419 @default.
- W4377018114 cites W2794320412 @default.
- W4377018114 cites W2887276938 @default.
- W4377018114 cites W2946216397 @default.
- W4377018114 cites W2957809303 @default.
- W4377018114 cites W2965452585 @default.
- W4377018114 cites W2967028785 @default.
- W4377018114 cites W2995447396 @default.
- W4377018114 cites W2996029077 @default.
- W4377018114 cites W2996106944 @default.
- W4377018114 cites W3000894358 @default.
- W4377018114 cites W3011878562 @default.
- W4377018114 cites W3014276173 @default.
- W4377018114 cites W3028618163 @default.
- W4377018114 cites W3037522503 @default.
- W4377018114 cites W3043275946 @default.
- W4377018114 cites W3043481359 @default.
- W4377018114 cites W3080838328 @default.
- W4377018114 cites W3082515994 @default.
- W4377018114 cites W3088449656 @default.
- W4377018114 cites W3099567402 @default.
- W4377018114 cites W3111020316 @default.
- W4377018114 cites W3112814558 @default.
- W4377018114 cites W3119608025 @default.
- W4377018114 cites W3128603193 @default.
- W4377018114 cites W3148272723 @default.
- W4377018114 cites W3156178478 @default.
- W4377018114 cites W3160050851 @default.
- W4377018114 cites W3161455480 @default.
- W4377018114 cites W3165655050 @default.
- W4377018114 cites W3176290988 @default.
- W4377018114 cites W3188404302 @default.
- W4377018114 cites W3193722669 @default.
- W4377018114 cites W3196641346 @default.
- W4377018114 cites W3201075807 @default.
- W4377018114 cites W3207702147 @default.
- W4377018114 cites W3208247254 @default.
- W4377018114 cites W3215786057 @default.
- W4377018114 cites W4200108629 @default.
- W4377018114 cites W4200592973 @default.
- W4377018114 cites W4206226993 @default.
- W4377018114 cites W4210878941 @default.
- W4377018114 cites W4210970969 @default.
- W4377018114 cites W4211175126 @default.
- W4377018114 cites W4220658051 @default.
- W4377018114 cites W4221086068 @default.
- W4377018114 cites W4225582796 @default.
- W4377018114 cites W4229066984 @default.
- W4377018114 cites W4229336244 @default.
- W4377018114 cites W4281700232 @default.
- W4377018114 cites W4283315619 @default.
- W4377018114 cites W4283448353 @default.
- W4377018114 cites W4286111735 @default.
- W4377018114 cites W4309236559 @default.
- W4377018114 cites W4311674728 @default.
- W4377018114 doi "https://doi.org/10.1016/j.bioactmat.2023.05.001" @default.
- W4377018114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37250866" @default.
- W4377018114 hasPublicationYear "2023" @default.