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- W4377019005 abstract "Abstract Stem cell niches are defined as the microenvironments where stem cells home, receiving stimuli defining their fate. In vertebrates, stem cell niches are stable and physically confined compartments. Botryllus schlosseri is an invertebrate colonial chordate where temporary stem cell niches have been identified in adult individuals that are cyclically resorbed and replaced by a new generation of clonal zooids. B. schlosseri also displays remarkable regenerative abilities, being capable of whole-body regeneration, but the cellular source of these processes is still unknown. Here we identified by means of a high-resolution morphological characterization a new putative stem cell niche in the ampullae of the circulatory system acting as a stem cell source during asexual reproduction. Stem cells of the ampullae travel via the circulatory system and contribute to the development of several organs and could explain where stem cells contributing to whole-body regeneration are stored. The ampullae niches are stable during the life cycle and regeneration of B. schlosseri , while additional niches of the zooid are dynamically established and colonised by circulating stem cells. Our results reveal an unprecedented dynamicity of stem cell niches in highly regenerative invertebrates." @default.
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- W4377019005 date "2023-05-18" @default.
- W4377019005 modified "2023-09-29" @default.
- W4377019005 title "New permanent stem cell niche for development and regeneration in a chordate" @default.
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- W4377019005 doi "https://doi.org/10.1101/2023.05.15.540819" @default.
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