Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377019640> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4377019640 abstract "Background AT1 angiotensin II receptor (ATI) antagonists are beneficial in focal ischemia/reperfusion (I/R) cases. However, in cases of global I/R, such as cardiorespiratory arrest (CRA), ATI blocker’s effects are still unknown. Methods Rats were allocated into four groups: Sham group (SG) – animals submitted to surgical interventions, without CRA; Control group (CG) – animals submitted to CRA and ventricular fibrillation; Group AT1 (GAT1) – like CG, plus 0.2 mg/kg of Candesartan; Vehicle Group (VG): animals equally induced to CRA, and administration of 0.2 ml/kg of dimethyl sulfoxide. The rate of return of spontaneous circulation (ROSC), survival, hemodynamic variables, histopathology, and markers of tissue injury were analyzed. Results Compared to CG, the GAT1 group had a higher rate of ROSC (62.5% vs. 42.1%, p<0.0001), survival (100% vs. 62.5%, CI: 0.014-0.034; p = 0.027), lower incidence of arrhythmia after 10 minutes of ROSC, (10% vs. 62.5%, p=0.000) and lower neuronal and cardiac injury scores (p=0.025 and p=0.021, respectively). The groups did not differ regarding CRA duration, number of adrenaline doses, or number of defibrillations. Conclusion ATI receptor blockade was responsible for higher rates of ROSC and survival, in addition to demonstrating neuronal and myocardial protection. Highlights AT1 receptor block was responsible per higher rates of ROSC and survival in intervention group. The AT1 receptor block can be neuroprotector in ischemic injury caused by CPR. The candesartan administration during CPR can contribute with reduction of ventricular arrythmias." @default.
- W4377019640 created "2023-05-19" @default.
- W4377019640 creator A5045681443 @default.
- W4377019640 date "2023-05-18" @default.
- W4377019640 modified "2023-10-17" @default.
- W4377019640 title "Effect of AT1 receptor blockade on cardiovascular outcome after cardiorespiratory arrest: an experimental study in rats" @default.
- W4377019640 cites W1965693998 @default.
- W4377019640 cites W1980850364 @default.
- W4377019640 cites W1984169833 @default.
- W4377019640 cites W1994501076 @default.
- W4377019640 cites W1998777532 @default.
- W4377019640 cites W2017584707 @default.
- W4377019640 cites W2028984638 @default.
- W4377019640 cites W2051553348 @default.
- W4377019640 cites W2061001947 @default.
- W4377019640 cites W2079870772 @default.
- W4377019640 cites W2083631092 @default.
- W4377019640 cites W2083962501 @default.
- W4377019640 cites W2099901191 @default.
- W4377019640 cites W2119869567 @default.
- W4377019640 cites W2129588432 @default.
- W4377019640 cites W2132794471 @default.
- W4377019640 cites W2158013636 @default.
- W4377019640 cites W2163667608 @default.
- W4377019640 cites W2171853698 @default.
- W4377019640 cites W2571236208 @default.
- W4377019640 cites W2614879143 @default.
- W4377019640 cites W3012015646 @default.
- W4377019640 cites W4210992260 @default.
- W4377019640 doi "https://doi.org/10.1101/2023.05.16.540941" @default.
- W4377019640 hasPublicationYear "2023" @default.
- W4377019640 type Work @default.
- W4377019640 citedByCount "0" @default.
- W4377019640 crossrefType "posted-content" @default.
- W4377019640 hasAuthorship W4377019640A5045681443 @default.
- W4377019640 hasBestOaLocation W43770196401 @default.
- W4377019640 hasConcept C123915805 @default.
- W4377019640 hasConcept C126322002 @default.
- W4377019640 hasConcept C164705383 @default.
- W4377019640 hasConcept C170493617 @default.
- W4377019640 hasConcept C178853913 @default.
- W4377019640 hasConcept C2777055891 @default.
- W4377019640 hasConcept C2778165595 @default.
- W4377019640 hasConcept C2778468042 @default.
- W4377019640 hasConcept C2778619729 @default.
- W4377019640 hasConcept C2780036600 @default.
- W4377019640 hasConcept C2781005686 @default.
- W4377019640 hasConcept C2908929049 @default.
- W4377019640 hasConcept C42219234 @default.
- W4377019640 hasConcept C71924100 @default.
- W4377019640 hasConceptScore W4377019640C123915805 @default.
- W4377019640 hasConceptScore W4377019640C126322002 @default.
- W4377019640 hasConceptScore W4377019640C164705383 @default.
- W4377019640 hasConceptScore W4377019640C170493617 @default.
- W4377019640 hasConceptScore W4377019640C178853913 @default.
- W4377019640 hasConceptScore W4377019640C2777055891 @default.
- W4377019640 hasConceptScore W4377019640C2778165595 @default.
- W4377019640 hasConceptScore W4377019640C2778468042 @default.
- W4377019640 hasConceptScore W4377019640C2778619729 @default.
- W4377019640 hasConceptScore W4377019640C2780036600 @default.
- W4377019640 hasConceptScore W4377019640C2781005686 @default.
- W4377019640 hasConceptScore W4377019640C2908929049 @default.
- W4377019640 hasConceptScore W4377019640C42219234 @default.
- W4377019640 hasConceptScore W4377019640C71924100 @default.
- W4377019640 hasLocation W43770196401 @default.
- W4377019640 hasOpenAccess W4377019640 @default.
- W4377019640 hasPrimaryLocation W43770196401 @default.
- W4377019640 hasRelatedWork W1969226460 @default.
- W4377019640 hasRelatedWork W1990044643 @default.
- W4377019640 hasRelatedWork W1992236119 @default.
- W4377019640 hasRelatedWork W2052879846 @default.
- W4377019640 hasRelatedWork W2101703532 @default.
- W4377019640 hasRelatedWork W2109896298 @default.
- W4377019640 hasRelatedWork W2190466816 @default.
- W4377019640 hasRelatedWork W2332833873 @default.
- W4377019640 hasRelatedWork W2350886079 @default.
- W4377019640 hasRelatedWork W4377019640 @default.
- W4377019640 isParatext "false" @default.
- W4377019640 isRetracted "false" @default.
- W4377019640 workType "article" @default.