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- W4377019682 endingPage "102754" @default.
- W4377019682 startingPage "102754" @default.
- W4377019682 abstract "Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the most significant biological events in cancer progression. Cancer cells generally represent a higher oxidant level, which suggests a dual therapeutic strategy by regulating redox status (i.e., pro-oxidant therapy and/or antioxidant therapy). Indeed, pro-oxidant therapy exhibits a great anti-cancer capability, attributing to a higher oxidant accumulation within cancer cells, whereas antioxidant therapy to restore redox homeostasis has been claimed to fail in several clinical practices. Targeting the redox vulnerability of cancer cells by pro-oxidants capable of generating excessive reactive oxygen species (ROS) has surfaced as an important anti-cancer strategy. However, multiple adverse effects caused by the indiscriminate attacks of uncontrolled drug-induced OS on normal tissues and the drug-tolerant capacity of some certain cancer cells greatly limit their further applications. Herein, we review several representative oxidative anti-cancer drugs and summarize their side effects on normal tissues and organs, emphasizing that seeking a balance between pro-oxidant therapy and oxidative damage is of great value in exploiting next-generation OS-based anti-cancer chemotherapeutics." @default.
- W4377019682 created "2023-05-19" @default.
- W4377019682 creator A5002858113 @default.
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- W4377019682 creator A5067422087 @default.
- W4377019682 date "2023-07-01" @default.
- W4377019682 modified "2023-10-09" @default.
- W4377019682 title "Drug-induced oxidative stress in cancer treatments: Angel or devil?" @default.
- W4377019682 cites W1565605888 @default.
- W4377019682 cites W1895711625 @default.
- W4377019682 cites W1968140809 @default.
- W4377019682 cites W1968766681 @default.
- W4377019682 cites W1969524738 @default.
- W4377019682 cites W1971855540 @default.
- W4377019682 cites W1980128193 @default.
- W4377019682 cites W1982210031 @default.
- W4377019682 cites W1983937216 @default.
- W4377019682 cites W1984328540 @default.
- W4377019682 cites W1987857240 @default.
- W4377019682 cites W1990035048 @default.
- W4377019682 cites W2008236720 @default.
- W4377019682 cites W2022324504 @default.
- W4377019682 cites W2023503151 @default.
- W4377019682 cites W2027694461 @default.
- W4377019682 cites W2032816624 @default.
- W4377019682 cites W2051092698 @default.
- W4377019682 cites W2052397596 @default.
- W4377019682 cites W2055196208 @default.
- W4377019682 cites W2070423606 @default.
- W4377019682 cites W2070803838 @default.
- W4377019682 cites W2071798417 @default.
- W4377019682 cites W2083797385 @default.
- W4377019682 cites W2084501277 @default.
- W4377019682 cites W2086003413 @default.
- W4377019682 cites W2086667809 @default.
- W4377019682 cites W2102426852 @default.
- W4377019682 cites W2105956344 @default.
- W4377019682 cites W2111370380 @default.
- W4377019682 cites W2117800935 @default.
- W4377019682 cites W2118758371 @default.
- W4377019682 cites W2127049578 @default.
- W4377019682 cites W2135144012 @default.
- W4377019682 cites W2137499582 @default.
- W4377019682 cites W2139847043 @default.
- W4377019682 cites W2140525205 @default.
- W4377019682 cites W2144277227 @default.
- W4377019682 cites W2161892620 @default.
- W4377019682 cites W2165679025 @default.
- W4377019682 cites W2166291119 @default.
- W4377019682 cites W2193716145 @default.
- W4377019682 cites W2217992775 @default.
- W4377019682 cites W2275001158 @default.
- W4377019682 cites W2294886889 @default.
- W4377019682 cites W2295813732 @default.
- W4377019682 cites W2314083131 @default.
- W4377019682 cites W2342121822 @default.
- W4377019682 cites W2346697308 @default.
- W4377019682 cites W2426965800 @default.
- W4377019682 cites W2462101166 @default.
- W4377019682 cites W2507554828 @default.
- W4377019682 cites W2514234950 @default.
- W4377019682 cites W2516584807 @default.
- W4377019682 cites W2528999955 @default.
- W4377019682 cites W2540550614 @default.
- W4377019682 cites W2541390219 @default.
- W4377019682 cites W2555020059 @default.
- W4377019682 cites W2556049444 @default.
- W4377019682 cites W2560317023 @default.
- W4377019682 cites W2560894090 @default.
- W4377019682 cites W2561420332 @default.
- W4377019682 cites W2573963236 @default.
- W4377019682 cites W2581964534 @default.
- W4377019682 cites W2594430933 @default.
- W4377019682 cites W2594847724 @default.
- W4377019682 cites W2597494578 @default.
- W4377019682 cites W2599336749 @default.
- W4377019682 cites W2604619953 @default.
- W4377019682 cites W2606528598 @default.
- W4377019682 cites W2613326943 @default.
- W4377019682 cites W2613929012 @default.
- W4377019682 cites W2621333085 @default.
- W4377019682 cites W2709224048 @default.
- W4377019682 cites W2736417759 @default.
- W4377019682 cites W2736563004 @default.
- W4377019682 cites W2745555485 @default.
- W4377019682 cites W2763201457 @default.
- W4377019682 cites W2766261199 @default.
- W4377019682 cites W2769622412 @default.
- W4377019682 cites W2772666421 @default.
- W4377019682 cites W2777809930 @default.