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- W4377019811 abstract "Abstract The tetrameric water channel aquaporin-0 (AQP0) forms square arrays in lens membranes through an as yet unknown mechanism. Lens membranes are enriched in cholesterol and sphingomyelin, suggesting that these raft lipids may play a role in AQP0 array formation. We produced two-dimensional crystals of AQP0 in sphingomyelin membranes with low and high cholesterol content and determined their structures by electron crystallography. At the higher cholesterol concentration, cholesterol associates with AQP0 and shifts lipids in the cytoplasmic leaflet away from the bilayer center, increasing the hydrophobic thickness of the annular lipid shell. AQP0 tetramers may thus cluster to mitigate the resulting hydrophobic mismatch. Moreover, neighboring AQP0 tetramers sandwich a cholesterol in the center of the membrane. Since each tetramer interacts with four such ‘glue’ cholesterols, avidity effects may stabilize larger arrays. The principles proposed to drive AQP0 array formation could also underlie protein clustering in lipid rafts." @default.
- W4377019811 created "2023-05-19" @default.
- W4377019811 creator A5008247931 @default.
- W4377019811 creator A5059152784 @default.
- W4377019811 date "2023-05-18" @default.
- W4377019811 modified "2023-09-30" @default.
- W4377019811 title "Structure of aquaporin-0 arrays in sphingomyelin/cholesterol membranes and implications for lipid rafts" @default.
- W4377019811 cites W1223591524 @default.
- W4377019811 cites W1564861448 @default.
- W4377019811 cites W1964779269 @default.
- W4377019811 cites W1965530119 @default.
- W4377019811 cites W1965624710 @default.
- W4377019811 cites W1970349630 @default.
- W4377019811 cites W1971065288 @default.
- W4377019811 cites W1972145067 @default.
- W4377019811 cites W1972738796 @default.
- W4377019811 cites W1974718588 @default.
- W4377019811 cites W1976953072 @default.
- W4377019811 cites W1977569471 @default.
- W4377019811 cites W1979166300 @default.
- W4377019811 cites W1979722406 @default.
- W4377019811 cites W1985054845 @default.
- W4377019811 cites W1985294414 @default.
- W4377019811 cites W1985663887 @default.
- W4377019811 cites W1985685751 @default.
- W4377019811 cites W1988530230 @default.
- W4377019811 cites W1991655565 @default.
- W4377019811 cites W1991794210 @default.
- W4377019811 cites W1993801027 @default.
- W4377019811 cites W1995017064 @default.
- W4377019811 cites W1996204565 @default.
- W4377019811 cites W1998987638 @default.
- W4377019811 cites W2002508442 @default.
- W4377019811 cites W2005323712 @default.
- W4377019811 cites W2008728387 @default.
- W4377019811 cites W2012945956 @default.
- W4377019811 cites W2021520922 @default.
- W4377019811 cites W2021882008 @default.
- W4377019811 cites W2025594842 @default.
- W4377019811 cites W2026395206 @default.
- W4377019811 cites W2027408247 @default.
- W4377019811 cites W2029360750 @default.
- W4377019811 cites W2029487310 @default.
- W4377019811 cites W2031079887 @default.
- W4377019811 cites W2037735248 @default.
- W4377019811 cites W2039166035 @default.
- W4377019811 cites W2040806491 @default.
- W4377019811 cites W2042787593 @default.
- W4377019811 cites W2043801488 @default.
- W4377019811 cites W2046471176 @default.
- W4377019811 cites W2049762454 @default.
- W4377019811 cites W2050410538 @default.
- W4377019811 cites W2053312267 @default.
- W4377019811 cites W2056295864 @default.
- W4377019811 cites W2058930537 @default.
- W4377019811 cites W2064517335 @default.
- W4377019811 cites W2065335146 @default.
- W4377019811 cites W2065886456 @default.
- W4377019811 cites W2065895117 @default.
- W4377019811 cites W2070715585 @default.
- W4377019811 cites W2071533902 @default.
- W4377019811 cites W2072917759 @default.
- W4377019811 cites W2073585128 @default.
- W4377019811 cites W2073597941 @default.
- W4377019811 cites W2079046810 @default.
- W4377019811 cites W2080165498 @default.
- W4377019811 cites W2081606553 @default.
- W4377019811 cites W2084182098 @default.
- W4377019811 cites W2085909590 @default.
- W4377019811 cites W2086679183 @default.
- W4377019811 cites W2087778160 @default.
- W4377019811 cites W2088603936 @default.
- W4377019811 cites W2090520066 @default.
- W4377019811 cites W2092296126 @default.
- W4377019811 cites W2094186244 @default.
- W4377019811 cites W2098167941 @default.
- W4377019811 cites W2106912222 @default.
- W4377019811 cites W2108789507 @default.
- W4377019811 cites W2108921801 @default.
- W4377019811 cites W2110885272 @default.
- W4377019811 cites W2115040835 @default.
- W4377019811 cites W2116780642 @default.
- W4377019811 cites W2121936687 @default.
- W4377019811 cites W2125632831 @default.
- W4377019811 cites W2125872855 @default.
- W4377019811 cites W2128766971 @default.
- W4377019811 cites W2132262459 @default.
- W4377019811 cites W2132589721 @default.
- W4377019811 cites W2132629607 @default.
- W4377019811 cites W2134777419 @default.
- W4377019811 cites W2136558879 @default.
- W4377019811 cites W2143927412 @default.
- W4377019811 cites W2144081223 @default.
- W4377019811 cites W2147738214 @default.
- W4377019811 cites W2149360962 @default.
- W4377019811 cites W2149453359 @default.
- W4377019811 cites W2149585214 @default.
- W4377019811 cites W2151991230 @default.
- W4377019811 cites W2154269266 @default.
- W4377019811 cites W2155268568 @default.