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• W4377019866 endingPage "2563" @default.
• W4377019866 startingPage "2557" @default.
• W4377019866 abstract "The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components. The mechanistic basis of this barrier is found at multiple levels, including the adherens and tight junction proteins that tightly bind adjacent endothelial cells and the influence of neighboring pericytes, microglia, and astrocyte endfeet. In addition, extracellular matrix components of the vascular basement membrane play a critical role in establishing and maintaining blood-brain barrier integrity, not only by providing an adhesive substrate for blood-brain barrier cells to adhere to, but also by providing guidance cues that strongly influence vascular cell behavior. The extracellular matrix protein laminin is one of the most abundant components of the basement membrane, and several lines of evidence suggest that it plays a key role in directing blood-brain barrier behavior. In this review, we describe the basic structure of laminin and its receptors, the expression patterns of these molecules in central nervous system blood vessels and how they are altered in disease states, and most importantly, how genetic deletion of different laminin isoforms or their receptors reveals the contribution of these molecules to blood-brain barrier function and integrity. Finally, we discuss some of the important unanswered questions in the field and provide a to-do list of some of the critical outstanding experiments." @default.
• W4377019866 created "2023-05-19" @default.
• W4377019866 creator A5022012632 @default.
• W4377019866 creator A5082985537 @default.
• W4377019866 creator A5088577000 @default.
• W4377019866 date "2023-05-12" @default.
• W4377019866 modified "2023-10-18" @default.
• W4377019866 title "The importance of laminin at the blood-brain barrier" @default.
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