FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377019970> ?p ?o ?g. }

• W4377019970 endingPage "1144" @default.
• W4377019970 startingPage "1138" @default.
• W4377019970 abstract "¹⁶¹Tb is an interesting radionuclide for application in the treatment of neuroendocrine neoplasms’ small metastases and single cancer cells because of its conversion and Auger-electron emission. Tb has coordination chemistry similar to that of Lu; therefore, like ¹⁷⁷Lu, it can stably radiolabel DOTATOC, one of the leading peptides used for the treatment of neuroendocrine neoplasms. However, ¹⁶¹Tb is a recently developed radionuclide that has not yet been specified for clinical use. Therefore, the aim of the current work was to characterize and specify ¹⁶¹Tb and to develop a protocol for the synthesis and quality control of ¹⁶¹Tb-DOTATOC with a fully automated process conforming to good-manufacturing-practice guidelines, in view of its clinical use. <b>Methods:</b>¹⁶¹Tb, produced by neutron irradiation of ¹⁶⁰Gd in high-flux reactors followed by radiochemical separation from its target material, was characterized regarding its radionuclidic purity, chemical purity, endotoxin level, and radiochemical purity (RCP) in analogy to what is described in the European Pharmacopoeia for no-carrier-added ¹⁷⁷Lu. In addition, ¹⁶¹Tb was introduced into a fully automated cassette-module synthesis to produce ¹⁶¹Tb-DOTATOC, as used for ¹⁷⁷Lu-DOTATOC. The quality and stability of the produced radiopharmaceutical in terms of identity, RCP, and ethanol and endotoxin content were assessed by means of high-performance liquid chromatography, gas chromatography, and an endotoxin test, respectively. <b>Results:</b>¹⁶¹Tb produced under the described conditions showed, as the no-carrier-added ¹⁷⁷Lu, a pH of 1–2, radionuclidic purity and RCP of more than 99.9%, and an endotoxin level below the permitted range (175 IU/mL), indicating its appropriate quality for clinical use. In addition, an efficient and robust procedure for the automated production and quality control of ¹⁶¹Tb-DOTATOC with clinically applicable specifications and activity levels, that is, 1.0–7.4 GBq in 20 mL, was developed. The radiopharmaceutical’s quality control was also developed using chromatographic methods, which confirmed the product’s stability (RCP ≥ 95%) over 24 h. <b>Conclusion:</b> The current study demonstrated that ¹⁶¹Tb has appropriate features for clinical use. The developed synthesis protocol guarantees high yields and safe preparation of injectable ¹⁶¹Tb-DOTATOC. The investigated approach could be translated to other DOTA-derivatized peptides; thus, ¹⁶¹Tb could be successfully applied in clinical practice for radionuclide therapy." @default.
• W4377019970 created "2023-05-19" @default.
• W4377019970 creator A5008704894 @default.
• W4377019970 creator A5011105288 @default.
• W4377019970 creator A5027075021 @default.
• W4377019970 creator A5033922989 @default.
• W4377019970 creator A5035048827 @default.
• W4377019970 creator A5041743198 @default.
• W4377019970 creator A5056614563 @default.
• W4377019970 creator A5065532591 @default.
• W4377019970 creator A5074602256 @default.
• W4377019970 creator A5075904335 @default.
• W4377019970 date "2023-05-18" @default.
• W4377019970 modified "2023-10-10" @default.
• W4377019970 title "¹⁶¹Tb-DOTATOC Production Using a Fully Automated Disposable Cassette System: A First Step Toward the Introduction of¹⁶¹Tb into the Clinic" @default.
• W4377019970 cites W1981002414 @default.
• W4377019970 cites W1998383468 @default.
• W4377019970 cites W2008603343 @default.
• W4377019970 cites W2019911597 @default.
• W4377019970 cites W2025888580 @default.
• W4377019970 cites W2045692650 @default.
• W4377019970 cites W2079241416 @default.
• W4377019970 cites W2090257199 @default.
• W4377019970 cites W2110922803 @default.
• W4377019970 cites W2138944485 @default.
• W4377019970 cites W2148113725 @default.
• W4377019970 cites W2294365458 @default.
• W4377019970 cites W2411559315 @default.
• W4377019970 cites W2473078107 @default.
• W4377019970 cites W2573369749 @default.
• W4377019970 cites W2580241886 @default.
• W4377019970 cites W2947948130 @default.
• W4377019970 cites W2960982763 @default.
• W4377019970 cites W3007427867 @default.
• W4377019970 cites W3011631024 @default.
• W4377019970 cites W3039553746 @default.
• W4377019970 cites W3127205125 @default.
• W4377019970 cites W3136207132 @default.
• W4377019970 cites W3153744526 @default.
• W4377019970 cites W3176208875 @default.
• W4377019970 cites W3196188001 @default.
• W4377019970 cites W3199266799 @default.
• W4377019970 cites W3203242711 @default.
• W4377019970 cites W4211241899 @default.
• W4377019970 cites W4220843104 @default.
• W4377019970 doi "https://doi.org/10.2967/jnumed.122.265268" @default.
• W4377019970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37201956" @default.
• W4377019970 hasPublicationYear "2023" @default.
• W4377019970 type Work @default.
• W4377019970 citedByCount "2" @default.
• W4377019970 countsByYear W43770199702023 @default.
• W4377019970 crossrefType "journal-article" @default.
• W4377019970 hasAuthorship W4377019970A5008704894 @default.
• W4377019970 hasAuthorship W4377019970A5011105288 @default.
• W4377019970 hasAuthorship W4377019970A5027075021 @default.
• W4377019970 hasAuthorship W4377019970A5033922989 @default.
• W4377019970 hasAuthorship W4377019970A5035048827 @default.
• W4377019970 hasAuthorship W4377019970A5041743198 @default.
• W4377019970 hasAuthorship W4377019970A5056614563 @default.
• W4377019970 hasAuthorship W4377019970A5065532591 @default.
• W4377019970 hasAuthorship W4377019970A5074602256 @default.
• W4377019970 hasAuthorship W4377019970A5075904335 @default.
• W4377019970 hasBestOaLocation W43770199701 @default.
• W4377019970 hasConcept C13965031 @default.
• W4377019970 hasConcept C177322064 @default.
• W4377019970 hasConcept C185592680 @default.
• W4377019970 hasConceptScore W4377019970C13965031 @default.
• W4377019970 hasConceptScore W4377019970C177322064 @default.
• W4377019970 hasConceptScore W4377019970C185592680 @default.
• W4377019970 hasIssue "7" @default.
• W4377019970 hasLocation W43770199701 @default.
• W4377019970 hasLocation W43770199702 @default.
• W4377019970 hasLocation W43770199703 @default.
• W4377019970 hasLocation W43770199704 @default.
• W4377019970 hasLocation W43770199705 @default.
• W4377019970 hasOpenAccess W4377019970 @default.
• W4377019970 hasPrimaryLocation W43770199701 @default.
• W4377019970 hasRelatedWork W1531601525 @default.
• W4377019970 hasRelatedWork W2319480705 @default.
• W4377019970 hasRelatedWork W2384464875 @default.
• W4377019970 hasRelatedWork W2398689458 @default.
• W4377019970 hasRelatedWork W2606230654 @default.
• W4377019970 hasRelatedWork W2607424097 @default.
• W4377019970 hasRelatedWork W2748952813 @default.
• W4377019970 hasRelatedWork W2899084033 @default.
• W4377019970 hasRelatedWork W2948807893 @default.
• W4377019970 hasRelatedWork W2778153218 @default.
• W4377019970 hasVolume "64" @default.
• W4377019970 isParatext "false" @default.
• W4377019970 isRetracted "false" @default.
• W4377019970 workType "article" @default.