Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377019979> ?p ?o ?g. }
- W4377019979 endingPage "99" @default.
- W4377019979 startingPage "82" @default.
- W4377019979 abstract "The inability to cross the plasma membranes traditionally limited the therapeutic use of recombinant proteins. However, in the last two decades, novel technologies made delivering proteins inside the cells possible. This allowed researchers to unlock intracellular targets, once considered 'undruggable', bringing a new research area to emerge. Protein transfection systems display a large potential in a plethora of applications. However, their modality of action is often unclear, and cytotoxic effects are elevated, whereas experimental conditions to increase transfection efficacy and cell viability still need to be identified. Furthermore, technical complexity often limits in vivo experimentation, while challenging industrial and clinical translation. This review highlights the applications of protein transfection technologies, and then critically discuss the current methodologies and their limitations. Physical membrane perforation systems are compared to systems exploiting cellular endocytosis. Research evidence of the existence of either extracellular vesicles (EVs) or cell-penetrating peptides (CPPs)- based systems, that circumvent the endosomal systems is critically analysed. Commercial systems, novel solid-phase reverse protein transfection systems, and engineered living intracellular bacteria-based mechanisms are finally described. This review ultimately aims at finding new methodologies and possible applications of protein transfection systems, while helping the development of an evidence-based research approach." @default.
- W4377019979 created "2023-05-19" @default.
- W4377019979 creator A5048136850 @default.
- W4377019979 date "2023-10-01" @default.
- W4377019979 modified "2023-10-14" @default.
- W4377019979 title "Intracellular protein delivery: New insights into the therapeutic applications and emerging technologies" @default.
- W4377019979 cites W1219966704 @default.
- W4377019979 cites W127183670 @default.
- W4377019979 cites W1583466614 @default.
- W4377019979 cites W1823096434 @default.
- W4377019979 cites W1912159341 @default.
- W4377019979 cites W1971191097 @default.
- W4377019979 cites W1971195407 @default.
- W4377019979 cites W1976641407 @default.
- W4377019979 cites W1981427767 @default.
- W4377019979 cites W1982281628 @default.
- W4377019979 cites W1983727696 @default.
- W4377019979 cites W1987464084 @default.
- W4377019979 cites W1991037959 @default.
- W4377019979 cites W1995518628 @default.
- W4377019979 cites W1996805840 @default.
- W4377019979 cites W2001551870 @default.
- W4377019979 cites W2001582257 @default.
- W4377019979 cites W2002822282 @default.
- W4377019979 cites W2007483105 @default.
- W4377019979 cites W2010911075 @default.
- W4377019979 cites W2012187239 @default.
- W4377019979 cites W2016307451 @default.
- W4377019979 cites W2016583991 @default.
- W4377019979 cites W2017224987 @default.
- W4377019979 cites W2018078395 @default.
- W4377019979 cites W2021723275 @default.
- W4377019979 cites W2023852421 @default.
- W4377019979 cites W2028842998 @default.
- W4377019979 cites W2031398120 @default.
- W4377019979 cites W2031515322 @default.
- W4377019979 cites W2034812646 @default.
- W4377019979 cites W2040078811 @default.
- W4377019979 cites W2045513624 @default.
- W4377019979 cites W2047630413 @default.
- W4377019979 cites W2052225170 @default.
- W4377019979 cites W2053716543 @default.
- W4377019979 cites W2054077259 @default.
- W4377019979 cites W2054374733 @default.
- W4377019979 cites W2054434888 @default.
- W4377019979 cites W2056804961 @default.
- W4377019979 cites W2057081438 @default.
- W4377019979 cites W2065654462 @default.
- W4377019979 cites W2068042099 @default.
- W4377019979 cites W2072822881 @default.
- W4377019979 cites W2073217307 @default.
- W4377019979 cites W2074324224 @default.
- W4377019979 cites W2075782194 @default.
- W4377019979 cites W2076226743 @default.
- W4377019979 cites W2076859770 @default.
- W4377019979 cites W2079154240 @default.
- W4377019979 cites W2079335891 @default.
- W4377019979 cites W2082468518 @default.
- W4377019979 cites W2083663368 @default.
- W4377019979 cites W2092327932 @default.
- W4377019979 cites W2103262726 @default.
- W4377019979 cites W2106080227 @default.
- W4377019979 cites W2109741979 @default.
- W4377019979 cites W2110258322 @default.
- W4377019979 cites W2111560326 @default.
- W4377019979 cites W2129842163 @default.
- W4377019979 cites W2131054979 @default.
- W4377019979 cites W2134178616 @default.
- W4377019979 cites W2135093868 @default.
- W4377019979 cites W2136501441 @default.
- W4377019979 cites W2136702130 @default.
- W4377019979 cites W2138619479 @default.
- W4377019979 cites W2140393378 @default.
- W4377019979 cites W2143608477 @default.
- W4377019979 cites W2152936026 @default.
- W4377019979 cites W2153540006 @default.
- W4377019979 cites W2156511162 @default.
- W4377019979 cites W2157327967 @default.
- W4377019979 cites W2160718001 @default.
- W4377019979 cites W2162076458 @default.
- W4377019979 cites W2166618356 @default.
- W4377019979 cites W2168812241 @default.
- W4377019979 cites W2169106595 @default.
- W4377019979 cites W2179649617 @default.
- W4377019979 cites W2219118753 @default.
- W4377019979 cites W2220162928 @default.
- W4377019979 cites W2308374231 @default.
- W4377019979 cites W2318836517 @default.
- W4377019979 cites W2321872032 @default.
- W4377019979 cites W2324062619 @default.
- W4377019979 cites W2324105842 @default.
- W4377019979 cites W2345376584 @default.
- W4377019979 cites W2476482095 @default.
- W4377019979 cites W2504492994 @default.
- W4377019979 cites W2513438212 @default.
- W4377019979 cites W2519826683 @default.
- W4377019979 cites W2524443989 @default.
- W4377019979 cites W2534941929 @default.