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• W4377020120 abstract "<b>Abstract ID 14181</b> <b>Poster Board 498</b> <b>Background:</b> Neurodegeneration is a slow but progressive loss of neuronal cells in certain brain regions and is the main pathologic feature of Alzheimer’s disease and Parkinson’s disease (Francis et al., 2020). Neurodegeneration can be found in the brain at various neuronal circuitry levels, from molecular to systemic. Based on the fact that there is presently no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable. However, some research has shown that oxidative stress and inflammation contribute to neurodegeneration (Pereira et al., 2021). It is estimated that 50 million people worldwide suffer from neurodegenerative diseases at the moment and that by the year 2050, this figure will be as high as 115 million people (Rodriguez et al., 2015). Lipopolysaccharides (LPS) which are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core, and inner core joined by a covalent bond, can cause an acute inflammatory response by triggering the release of a vast number of inflammatory cytokines in various cell types (Calin et al., 2017). In addition, it is widely recognized as a potent activator of monocytes and macrophages (Ngkelo et al., 2012). Bacterial LPS has sometimes been used to study inflammation because of the abundance of inflammatory effects that it generates through TLR4 signaling. Previous studies have shown an association between neuro-inflammation and neurodegenerative diseases such as Alzheimer’s disease. Therefore, the prevention of neuro-inflammation could be an alternative method or approach for the treatment of neurodegenerative diseases. Although thymoquinone has demonstrated anti-inflammatory properties in several studies. However, its neuroprotective action in LPS-induced neuro-inflammation and cognitive impairment has not been thoroughly investigated. Hence, this study investigated the neuroprotective effect of thymoquinone in LPS-induced cognitive impairment and neurodegeneration and its underlying mechanisms with lipopolysaccharide models in mice. <b>Methods:</b> Thirty-Five mice were assigned into five groups (n=7), group 1 (Saline Group), group 2 (LPS Group), Group 3 (TQ 15mg/Kg), group 4 (TQ 30mg/Kg), Group 5 (Donepezil 5mg/Kg). Animals in different groups were administered with vehicle (Normal Saline), thymoquinone, and donepezil for fourteen days. From the 8th day, sixty minutes after administering Vehicle/thymoquinone/donepezil, animals in groups 2, 3, 4, and 5 received LPS (500μg/Kg i.p.) consecutively for seven days. The administration was completed on the 14th day. Twenty-Four hours after the final administration, behavioral tests such as; Novel Object Recognition and Y-Maze test were used to assess cognitive functions, while elevated plus maze, open field, and light and dark box tests were used to evaluate anxiety. After that, the animals were sacrificed. Tumor Necrosis Factor-α (TNF-α) was assessed using ELISA techniques, NF-Kβ, inflammasome, and amyloid beta were quantified using immunohistochemistry, while β-secretase was measured with qPCR. COX Golgi staining was used to evaluate hippocampal damage. <b>Results:</b> LPS significantly impaired cognitive performance in the NORT and Y-maze while also inducing behavioral abnormalities, as opposed to the control group. The effects were all greatly improved by treatment with TQ 30mg/Kg. TQ also significantly reduced the expression of LPS-induced TNF-α, NF-Kβ, and inflammasome in the hippocampus and prefrontal cortex. However, TQ showed no change in the levels of β-secretase in the hippocampus and prefrontal cortex. TQ also prevents LPS-induced degeneration of dendrites in the hippocampus and prefrontal cortex. <b>Conclusion:</b> Result obtained suggests that TQ may possess a neuroprotective effect against LPS-induced neurodegeneration and cognitive impairment through mechanisms involving its anti-inflammatory properties." @default.
• W4377020120 created "2023-05-19" @default.
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• W4377020120 date "2023-05-18" @default.
• W4377020120 modified "2023-09-29" @default.
• W4377020120 title "Assessing how Neurodegeneration and Cognitive Impairment can be Ameliorated through the Neuroprotective Effect of Thymoquinone" @default.
• W4377020120 doi "https://doi.org/10.1124/jpet.122.141810" @default.
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