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• W4377020198 abstract "<b>Abstract ID 28922</b> <b>Poster Board 511</b> Although we and others have shown that exposure to e-cigarettes (e-cigs) in adulthood is associated with a host of negative health effects, including in the context of occlusive cardiovascular diseases, whether in utero exposure exerts any effects remains ill-defined. To this end, there is growing evidence that exposure of pregnant women to e-cigs is indeed linked to harm to their offspring, which is contrary to the misperceptions regarding their safety that are currently held by the general public. Thus, to address the aforementioned issues, we performed a platelet function and a transcriptomic (mRNA & miRNA) approaches to investigate the effects and mechanism by which in utero e-cigs exposure increases the risk of thrombosis in the offspring. We used a validated protocol to expose female mice to e-cigs one week before mating and throughout the entire period of gestation. Exposure stopped at birth, and offspring the males were utilized for experimentation at 10- 12 weeks of age. Our results showed altered platelet functional responses and gene expression in the mice that were subjected to <i>in utero</i> e-cigs exposure, in comparison to those exposed to clean air. Our <i>in vivo</i> studies showed that the <i>in utero</i> e-cig exposed mice had significantly shortened bleeding time (M =156.6 sec, SD= 222.1 sec) as well as occlusion time (M = 63 sec, SD = 39.72 sec) in comparison to clean air (M = 366 sec, SD = 108.7 sec) and (M = 187.2 sec, SD = 54.13 sec) respectively. RNA sequencing demonstrated distinct changes in the gene-expression profile of circulating platelets of <i>in-utero</i> e-cig exposed mice. Gene enrichment analysis of differential expressed genes show changes in pathways associated with platelet activation, hemostasis, and inflammation. Using miRNA-seq, we found 29 differentially expressed miRNAs in <i>in-utero</i> e-cig exposed platelet compared with clean air. Using miRNA databases, interactions analysis between differential expressed miRNA and differentially expressed genes showed clear validated interactions. These findings demonstrate that <i>in-utero</i> e-cig exposure is associated with platelet enhancement, which may contribute to increasing in the risk of thrombosis in adulthood." @default.
• W4377020198 created "2023-05-19" @default.
• W4377020198 creator A5012911879 @default.
• W4377020198 date "2023-05-18" @default.
• W4377020198 modified "2023-09-29" @default.
• W4377020198 title "Platelet Function and Gene Expression in E-cigarette In Utero Exposed Mice" @default.
• W4377020198 doi "https://doi.org/10.1124/jpet.122.289220" @default.
• W4377020198 hasPublicationYear "2023" @default.
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