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- W4377020281 abstract "<b>Abstract ID 53076</b> <b>Poster Board 350</b> Vesicle fusion at the plasma membrane is a critical process for releasing hormones and neurotransmitters and delivering cognate GPCRs to the cell surface. Although the fusion machinery of soluble NSF-attachment receptor protein (SNARE) complex mediating neurotransmitter release is extensively studied, the SNARE complex that mediates GPCR surface delivery is largely unknown. Using multiple microscopy methods, we find subtype-dependent cargo-selectivity underlying the v-SNAREs, vesicle-associated membrane proteins (VAMPs). VAMP2 was preferentially enriched in vesicles that mediate the surface delivery of mu opioid receptor (MOR), and was required selectively for MOR recycling, but not for beta2 adrenergic receptor or transferrin receptor. Interestingly, VAMP2 was not preferentially presenting on endosomes that contained MOR, suggesting the involvement of local sorting mechanism. Together, our results identify VAMP2 as a cargo-selective v-SNARE and suggest that surface delivery of specific GPCRs is mediated by distinct SNARE complexes. H.C. was supported by Rackham Graduate Student Research Grant under JE RGSGss0666 from the University of Michigan. M.A.P. was supported by NIH grant GM117425 and DA055026, and NSF grant 1935926." @default.
- W4377020281 created "2023-05-19" @default.
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- W4377020281 date "2023-05-18" @default.
- W4377020281 modified "2023-09-29" @default.
- W4377020281 title "Cargo-selectivity of Vesicle-associated Membrane Proteins in GPCR Exocytosis" @default.
- W4377020281 doi "https://doi.org/10.1124/jpet.122.530760" @default.
- W4377020281 hasPublicationYear "2023" @default.
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