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• W4377020935 abstract "<b>Abstract ID 53568</b> <b>Poster Board 444</b> Rhodanine (derived from thiazolidine), a heterocyclic compound, plays an essential role in the biological system of humans. Its derivatives are present in drugs used in antibiotics, antiviruses, antidiabetics, and antifungals. Rhodanine and its derivatives can prevent HIV-1 integrase, JSP-1 Phosphates, RNA polymerase, hepatitis C virus NS5B polymerase, and PMT1 mannosyl transferase. We hypothesize that the shape-controlled synthesis of Polyrhodanine will provide an exciting perspective for diagnosing and treating diseases, including cancer. In our research, we investigate the synthesis of Polyrhodanine in a single-step oxidation-reduction reaction in the presence of transition metals in the microwave. Two morphologies for Polyrhodanine have been identified depending on the metal: core-shell and nanotubular. In the first step of the reaction, the rhodamine monomer forms a one-dimensional complex with the metal ions (Copper (I) Acetate) due to coordinative interaction. In the second step, the oxidation of Rhodanine and the reduction of metal ions result in the polymerization of Rhodanine into core-shell nano-micro spheres with embedded metal nanoparticles. The product is analyzed via Infra-Red and UV-vis Spectroscopy, SEM (Scanning Electron Microscopy), EDX (Energy Dispersive X-ray spectroscopy), and TEM (Transmission Electron Microscopy). Subsequently, we tested our compound in a human lung cancer cell line, namely A549, to measure cell viability by the colorimetric MTT (3- [4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The MTT assay is used to measure cellular metabolic activity as an indicator of cell viability and cytotoxicity. The underlying principle is the ability of NADPH-dependent cellular oxidoreductase enzyme secreted by the mitochondria to convert the tetrazolium dye into insoluble formazan crystals. More formazan crystal formation indicates more viable cells. In our experiment, 20,000 cells were plated in each well of a 96-well plate and treated with the compound for 48 hours to investigate the viability of lung cancer cells. Our data shows viability of A549 cells decreases in a dose dependent manner with treatment concentrations ranging from 0.01μM to 1μM in comparison to cells in the DMSO control treatment group. Our present focus is to investigate the cell signaling pathways, by real-time PCR and Western blotting, that could be altered by our compound to identify expression of key genes and protein, that are known to be dysregulated in lung cancer. Future studies will focus on investigating effect in other cancer cell lines, including triple negative breast cancer cells. Acknowledgements: Queensborough Community College NIH Bridges to Baccalaureate Program 5R25GM065096-21 and Research Foundation, CUNY." @default.
• W4377020935 created "2023-05-19" @default.
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• W4377020935 date "2023-05-18" @default.
• W4377020935 modified "2023-09-29" @default.
• W4377020935 title "Synthesis And Anticancer Properties of Polyrhodanine Copper Nanocomposites" @default.
• W4377020935 doi "https://doi.org/10.1124/jpet.122.535680" @default.
• W4377020935 hasPublicationYear "2023" @default.
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