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- W4377024346 abstract "Summary Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which can be studied in large-scale, biophysically detailed models. We present a model comprising eight somatosensory cortex subregions, 4.2 million morpho-logical and electrically-detailed neurons, and 13.2 billion local and long-range synapses. In silico tools enabled reproduction and extension of complex laboratory experiments under a single parameterization, providing strong validation. We reproduced millisecond-precise stimulus-responses, stimulus-encoding under targeted optogenetic activation, and selective propagation of stimulus-evoked activity to downstream areas. The model’s di-rect correspondence with biology generated predictions about how multiscale organisation shapes activity. We predict that structural and functional recurrency increases towards deeper layers and that stronger innervation by long-range connectivity increases local correlated activity. The model also predicts the role of inhibitory interneuron types in stimulus encoding, and of different layers in driving layer 2/3 stimulus responses. Simu-slation tools and a large subvolume of the model are made available." @default.
- W4377024346 created "2023-05-19" @default.
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- W4377024346 date "2023-05-17" @default.
- W4377024346 modified "2023-10-01" @default.
- W4377024346 title "Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation" @default.
- W4377024346 cites W1147225692 @default.
- W4377024346 cites W1546395192 @default.
- W4377024346 cites W1751265558 @default.
- W4377024346 cites W1875306972 @default.
- W4377024346 cites W1904639934 @default.
- W4377024346 cites W1921182138 @default.
- W4377024346 cites W1940417817 @default.
- W4377024346 cites W1971366695 @default.
- W4377024346 cites W1975389666 @default.
- W4377024346 cites W1978317269 @default.
- W4377024346 cites W1978936152 @default.
- W4377024346 cites W1981156067 @default.
- W4377024346 cites W1987510656 @default.
- W4377024346 cites W1990931283 @default.
- W4377024346 cites W1991762922 @default.
- W4377024346 cites W2004417373 @default.
- W4377024346 cites W2006415669 @default.
- W4377024346 cites W2007495909 @default.
- W4377024346 cites W2008689757 @default.
- W4377024346 cites W2010533282 @default.
- W4377024346 cites W2015334431 @default.
- W4377024346 cites W2016880507 @default.
- W4377024346 cites W2022568453 @default.
- W4377024346 cites W2025603247 @default.
- W4377024346 cites W2025653075 @default.
- W4377024346 cites W2029532682 @default.
- W4377024346 cites W2031543773 @default.
- W4377024346 cites W2031851277 @default.
- W4377024346 cites W2041180516 @default.
- W4377024346 cites W2041411678 @default.
- W4377024346 cites W2041918412 @default.
- W4377024346 cites W2042076346 @default.
- W4377024346 cites W2042422091 @default.
- W4377024346 cites W2052401197 @default.
- W4377024346 cites W2054930781 @default.
- W4377024346 cites W2062450961 @default.
- W4377024346 cites W2063812162 @default.
- W4377024346 cites W2065416066 @default.
- W4377024346 cites W2072666824 @default.
- W4377024346 cites W2075187489 @default.
- W4377024346 cites W2075289371 @default.
- W4377024346 cites W2083809416 @default.
- W4377024346 cites W2085989895 @default.
- W4377024346 cites W2086664483 @default.
- W4377024346 cites W2086997566 @default.
- W4377024346 cites W2098520377 @default.
- W4377024346 cites W2103423972 @default.
- W4377024346 cites W2105805026 @default.
- W4377024346 cites W2106566258 @default.
- W4377024346 cites W2116228954 @default.
- W4377024346 cites W2117113597 @default.
- W4377024346 cites W2122753892 @default.
- W4377024346 cites W2124727398 @default.