Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377024781> ?p ?o ?g. }
- W4377024781 abstract "Abstract Postnatal neurogenesis has been shown to rely on the endocannabinoid system. Here we aimed at unravelling the role of Cannabidivarin (CBDV), a non-psychoactive cannabinoid, with high affinity for the non-classical cannabinoid receptor TRPV1, on subventricular zone (SVZ) postnatal neurogenesis. Using the neurosphere assay, SVZ-derived neural stem/progenitor cells (NSPCs) were incubated with CBDV and/or 5’-Iodoresinferotoxin (TRPV1 antagonist), and their role on cell viability, proliferation, and differentiation were dissected. CBDV was able to promote, through a TRPV1-dependent mechanism, cell survival, cell proliferation and neuronal differentiation. Furthermore, pulse-chase experiments revealed that CBDV-induced neuronal differentiation was a result of cell cycle exit of NSPCs. Regarding oligodendrocyte differentiation, CBDV inhibited oligodendrocyte differentiation and maturation. Since our data suggested that the CBDV-induced modulation of NSPCs acted via TRPV1, a sodium-calcium channel, and that intracellular calcium levels are known regulators of NSPCs fate and neuronal maturation, single cell calcium imaging was performed to evaluate the functional response of SVZ-derived cells. We observed that CBDV-responsive cells displayed a two-phase calcium influx profile, being the initial phase dependent on TRPV1 activation. Taken together, this work unveiled a novel and untapped neurogenic potential of CBDV via TRPV1 modulation. These findings pave the way to future neural stem cell biological studies and repair strategies by repurposing this non-psychoactive cannabinoid as a valuable therapeutic target." @default.
- W4377024781 created "2023-05-19" @default.
- W4377024781 creator A5002865588 @default.
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- W4377024781 creator A5021255614 @default.
- W4377024781 creator A5027568151 @default.
- W4377024781 creator A5032666849 @default.
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- W4377024781 creator A5048412199 @default.
- W4377024781 creator A5051760428 @default.
- W4377024781 creator A5074787856 @default.
- W4377024781 date "2023-05-17" @default.
- W4377024781 modified "2023-10-14" @default.
- W4377024781 title "Unravelling a novel role for Cannabidivarin in the modulation of subventricular zone postnatal neurogenesis" @default.
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