Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029005> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4377029005 abstract "<b>Abstract ID 16953</b> <b>Poster Board 330</b> Mechanistic target of Rapamycin (mTOR) complex 1 (mTORC1) integrates inputs from multiple pathways and senses diverse signals to regulate cell growth, protein translation, and proliferation. Given that signal compartmentalization can enhance signaling specificity and efficiency, spatial regulation of mTORC1 appears to be critical for this multifaceted signaling complex as it has been reported at many subcellular locations. For example, mTORC1 at the lysosome is regulated by both amino acids and growth factors and functions to promote translation and suppress autophagy. We have also previously reported a nuclear pool of mTORC1 that is regulated by nuclear Akt, by a regulatory mode distinct from the lysosomal pool of mTORC1. However, the functions of subcellular pools of mTORC1, in particular in the nucleus, are not well understood. A major limitation in the field is the availability of tools to assess the activity and function of spatially compartmentalized signaling enzymes in living cells. We have developed a genetically encodable inhibitor of mTORC1, TerminaTOR, that can be spatially compartmentalized to specifically inhibit a subcellular pool of mTORC1. Using TerminaTOR, we conducted a phosphoproteomics study to elucidate the role of nuclear mTORC1 in regulating transcriptional proteins. Several transcription-related proteins were differentially expressed or phosphorylated upon nuclear mTORC1 inhibition. Furthermore, the phosphoproteomics data revealed interesting crosstalk between nuclear mTORC1 and Erk activity, which we investigated more in depth by imaging and biochemical assays. Based on our findings, we hypothesize that there is a mechanism of spatially regulated crosstalk between nuclear Erk and nuclear mTORC1 that may play a role in transcription." @default.
- W4377029005 created "2023-05-19" @default.
- W4377029005 creator A5009651541 @default.
- W4377029005 creator A5045929531 @default.
- W4377029005 creator A5050379324 @default.
- W4377029005 creator A5055174519 @default.
- W4377029005 creator A5073998882 @default.
- W4377029005 date "2023-05-18" @default.
- W4377029005 modified "2023-10-16" @default.
- W4377029005 title "Spatial Compartmentalization of mTORC1 to the Nucleus to Regulate Transcription and Impact Nuclear Erk Signaling" @default.
- W4377029005 doi "https://doi.org/10.1124/jpet.122.169530" @default.
- W4377029005 hasPublicationYear "2023" @default.
- W4377029005 type Work @default.
- W4377029005 citedByCount "0" @default.
- W4377029005 crossrefType "proceedings-article" @default.
- W4377029005 hasAuthorship W4377029005A5009651541 @default.
- W4377029005 hasAuthorship W4377029005A5045929531 @default.
- W4377029005 hasAuthorship W4377029005A5050379324 @default.
- W4377029005 hasAuthorship W4377029005A5055174519 @default.
- W4377029005 hasAuthorship W4377029005A5073998882 @default.
- W4377029005 hasBestOaLocation W43770290051 @default.
- W4377029005 hasConcept C104317684 @default.
- W4377029005 hasConcept C110455231 @default.
- W4377029005 hasConcept C11960822 @default.
- W4377029005 hasConcept C120665830 @default.
- W4377029005 hasConcept C121332964 @default.
- W4377029005 hasConcept C169822122 @default.
- W4377029005 hasConcept C181199279 @default.
- W4377029005 hasConcept C190062978 @default.
- W4377029005 hasConcept C2776879804 @default.
- W4377029005 hasConcept C2780114586 @default.
- W4377029005 hasConcept C2780723820 @default.
- W4377029005 hasConcept C49805395 @default.
- W4377029005 hasConcept C55493867 @default.
- W4377029005 hasConcept C59157529 @default.
- W4377029005 hasConcept C62478195 @default.
- W4377029005 hasConcept C6675166 @default.
- W4377029005 hasConcept C86339819 @default.
- W4377029005 hasConcept C86554907 @default.
- W4377029005 hasConcept C86803240 @default.
- W4377029005 hasConcept C87325107 @default.
- W4377029005 hasConcept C95444343 @default.
- W4377029005 hasConcept C97029542 @default.
- W4377029005 hasConcept C98490376 @default.
- W4377029005 hasConceptScore W4377029005C104317684 @default.
- W4377029005 hasConceptScore W4377029005C110455231 @default.
- W4377029005 hasConceptScore W4377029005C11960822 @default.
- W4377029005 hasConceptScore W4377029005C120665830 @default.
- W4377029005 hasConceptScore W4377029005C121332964 @default.
- W4377029005 hasConceptScore W4377029005C169822122 @default.
- W4377029005 hasConceptScore W4377029005C181199279 @default.
- W4377029005 hasConceptScore W4377029005C190062978 @default.
- W4377029005 hasConceptScore W4377029005C2776879804 @default.
- W4377029005 hasConceptScore W4377029005C2780114586 @default.
- W4377029005 hasConceptScore W4377029005C2780723820 @default.
- W4377029005 hasConceptScore W4377029005C49805395 @default.
- W4377029005 hasConceptScore W4377029005C55493867 @default.
- W4377029005 hasConceptScore W4377029005C59157529 @default.
- W4377029005 hasConceptScore W4377029005C62478195 @default.
- W4377029005 hasConceptScore W4377029005C6675166 @default.
- W4377029005 hasConceptScore W4377029005C86339819 @default.
- W4377029005 hasConceptScore W4377029005C86554907 @default.
- W4377029005 hasConceptScore W4377029005C86803240 @default.
- W4377029005 hasConceptScore W4377029005C87325107 @default.
- W4377029005 hasConceptScore W4377029005C95444343 @default.
- W4377029005 hasConceptScore W4377029005C97029542 @default.
- W4377029005 hasConceptScore W4377029005C98490376 @default.
- W4377029005 hasLocation W43770290051 @default.
- W4377029005 hasOpenAccess W4377029005 @default.
- W4377029005 hasPrimaryLocation W43770290051 @default.
- W4377029005 hasRelatedWork W1415994077 @default.
- W4377029005 hasRelatedWork W2012302802 @default.
- W4377029005 hasRelatedWork W2049551611 @default.
- W4377029005 hasRelatedWork W2070518772 @default.
- W4377029005 hasRelatedWork W2168920565 @default.
- W4377029005 hasRelatedWork W2884120876 @default.
- W4377029005 hasRelatedWork W2971191856 @default.
- W4377029005 hasRelatedWork W4238664459 @default.
- W4377029005 hasRelatedWork W4240597947 @default.
- W4377029005 hasRelatedWork W4377029005 @default.
- W4377029005 isParatext "false" @default.
- W4377029005 isRetracted "false" @default.
- W4377029005 workType "article" @default.