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• W4377029013 abstract "<b>Abstract ID 17622</b> <b>Poster Board 561</b> Arterial thrombosis remains the most common cause of death in the developed world. Clopidogrel, a P2Y₁₂ antagonist, is often prescribed to inhibit platelet activation and aggregation; however, patients who take clopidogrel are known to have cerebral bleeding events. The purpose of this study was to determine if the clopidogrel bleeding effect is dependent on P2Y₁₂ receptor inhibition. Previous research from our laboratory suggests that clopidogrel possesses inhibitory effects on hemostasis independent of platelet P2Y₁₂ inhibition. We hypothesized that P2Y₁₂-deficient mice treated with clopidogrel will bleed significantly more than the P2Y₁₂-deficient mice treated with the vehicle. A tail-bleeding assay was used to determine clopidogrel9s effect on hemostasis. P2Y₁₂ deficient mice were administered clopidogrel (10 mg/kg) or vehicle daily for five days before the procedure was performed. Bleeding was evaluated using a tail tip amputation assay. After tip amputation, the tail was quickly placed in a tube containing Drabkin’s reagent. Blood loss was determined by measuring the concentration of hemoglobin in the tube using a standard curve. P2Y₁₂-deficient animals bled more (5.955 ± 1.159 g/dl) than their wildtype littermates (2.491 ± 0.962 g/dl). Importantly, our data demonstrated that clopidogrel treatment induced more bleeding in both the P2Y₁₂-deficient mice (7.921 ± 1.015 g/dl) and wildtype mice (3.898 ± 0.324 g/dl) compared to drug vehicle. These results suggest that clopidogrel’s bleeding effect is not completely dependent on the P2Y₁₂ receptor inhibition. Other elements in the hemostatic system, such as the vessel-related factors, could be responsible for the observed clopidogrel bleeding effects. This work was funded in part by the ASPET Summer Undergraduate Research Fellowship." @default.
• W4377029013 created "2023-05-19" @default.
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• W4377029013 date "2023-05-18" @default.
• W4377029013 modified "2023-09-29" @default.
• W4377029013 title "Clopidogrel Induces More Bleeding in P2Y₁₂-deficient Mice: Optimization of Murine Tail Bleeding Assay" @default.
• W4377029013 doi "https://doi.org/10.1124/jpet.122.176220" @default.
• W4377029013 hasPublicationYear "2023" @default.
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