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- W4377029059 abstract "<b>Abstract ID 14539</b> <b>Poster Board 222</b> The frequency of nonalcoholic fatty liver disease (NAFLD) in people with type 2 diabetes (T2D) is rising quickly worldwide. There may be a positive impact of LCZ696 on liver disease. Therefore, the goal of the current study was to explore LCZ6969s therapeutic potential and underlying mechanism in T2D-induced NAFLD. In this study, a high-fat diet (HFD) and a single dose of streptozotocin (STZ, 30 mg/kg body weight) were given to rats to create a T2D model.T2D animals received valsartan or LCZ696 orally for eight weeks. The liver enzymes (AST and ALT), lipid profile, cytokines, nuclear factor kappa B (NF-κB), oxidative stress, caspase-3 activity, Bax expression, and caspase-3 expression were all significantly increased in HFD/STZ rats while IL-10, antioxidant markers, and Bcl-2 expression were significantly decreased. HFD/STZ rats also had hyperglycemia and impaired insulin secretion. When given to diabetic rats, LCZ696 decreased the levels of glucose, AST, ALT and lipid profile in the serum. Additionally, ELISA findings showed that diabetic rats treated with LCZ696 showed decreased levels of pro-inflammatory (IL-1, TNF-, and IL-6) and increased levels of anti-inflammatory (IL-10) cytokine. In addition, NF-κB and caspase-3 activity were shown to be significantly reduced. Diabetic rats treated with LCZ696 showed clear improvements in GSH content and other antioxidant enzyme levels, in addition to a considerable reduction in TBARS levels, at the level of hepatic tissue homogenate. Additionally, LCZ696 increased the expression of the Bcl-2 protein while suppressing the expression of the Bax and cleaved caspase-3 proteins. These biochemical findings were strengthened and considerably supported by improvements in histological alterations in liver tissues. In conclusion, LCZ696 reduced NAFLD through various mechanisms such as apoptosis and inflammation inhibition." @default.
- W4377029059 created "2023-05-19" @default.
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- W4377029059 date "2023-05-18" @default.
- W4377029059 modified "2023-09-29" @default.
- W4377029059 title "Sacubitril/Valsartan Alleviates Type 2 Diabetes-Induced NAFLD Through Modulation of Oxidative Stress, Inflammation and Apoptosis" @default.
- W4377029059 doi "https://doi.org/10.1124/jpet.122.145390" @default.
- W4377029059 hasPublicationYear "2023" @default.
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