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- W4377029074 abstract "<b>Abstract ID 17668</b> <b>Poster Board 11</b> A circuit mechanism was recently identified by our lab in which mu opioid peptide receptors (MOPRs) act to control reward consumption. We found that MOPRs are expressed on the lateral dorsal raphe nucleus (LDRN) terminals that project to the nucleus accumbens medial shell (mNAcSh) and are activated by retrogradely released enkephalin from mNAcSh itself (LDRN→mNAcSh). While MOPRs in mNAcSh are important for reward consumption, MOPRs necessarily act in concert with other neurochemical actuators. Recent data demonstrated that stimulation of non-specific LDRN→mNAcSh terminals could evoke either inhibitory or excitatory postsynaptic potentials in mNAcSh neurons, indicating that both GABAergic (vGAT) and glutamatergic (vGlut2) subpopulations are included in the LDRN→mNAcSh circuit. Whether vGAT or vGlut2 subcircuits have distinct roles in reward consumption is unknown. To isolate the potential subpopulation driving the expression of reward consumption behaviors, we simultaneously recorded vGlut2 and vGAT terminal activity using two calcium biosensors via dual-color fiber photometry in a sucrose consumption task. In this task, mice were allowed to consume sucrose pellets that were non-contingently delivered throughout the test session. Mice were tested ad libitum or after 24 hours of acute food deprivation. Additionally, mice were tested after systemic administration of the opioid antagonist naloxone to test if terminal activity depended on endogenous opioid receptors. We hypothesized that vGlut2, but not vGAT, terminal activity would decrease at the onset of sucrose consumption, and this decrease would be opioid dependent. Our rationale was informed by extensive literature indicating that consummatory behavior in mNAcSh is primarily mediated by decreased neural activity. Preliminary data suggests that vGlut2 terminal activity was reduced during reward consumption. Oppositely, vGAT terminal activity appears to slightly increase activity during the same behavioral epoch. While these results were represented across all conditions, the decrease in vGlut2 terminal activity was more robust during the food deprivation state. These findings provide initial, but greater understanding of the complex transient interactions glutamate could be playing in our LDRN→mNAcSh circuit. In the future, we will target each neural subpopulation via optogenetic stimulation to modulate reward consumption." @default.
- W4377029074 created "2023-05-19" @default.
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- W4377029074 date "2023-05-18" @default.
- W4377029074 modified "2023-09-29" @default.
- W4377029074 title "Characterizing a Mesolimbic Circuit for Opioid Reward" @default.
- W4377029074 doi "https://doi.org/10.1124/jpet.122.176680" @default.
- W4377029074 hasPublicationYear "2023" @default.
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