FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029104> ?p ?o ?g. }

• W4377029104 abstract "<b>Abstract ID 16515</b> <b>Poster Board 143</b> Alcohol use disorder (AUD) is a chronic, relapsing disease, highly comorbid with anxiety and depression. These states of negative affect experienced during withdrawal are hypothesized to drive alcohol seeking and relapse behavior. The bed nucleus of the stria terminalis (BNST) is a brain region responsible for the integration of negative affect and alcohol-related behaviors. Within this region, NMDARs are a major target of ethanol, capable of modulating ethanol-induced synaptic plasticity and transmission. Specifically, GluN2D subunit-containing NMDARs have recently emerged as a target of interest. Using a continuous access two-bottle choice mouse model of chronic ethanol intake followed by forced abstinence (CDFA), we demonstrated that dorsolateral BNST (dlBNST) GluN2D mRNA (<i>grin2d</i>) expression is decreased during periods of forced abstinence in female mice. However, the role of dlBNST GluN2D expression in the context of negative affect- and ethanol-related behaviors remains unknown. To answer this question, open field, elevated zero maze, and forced swim tasks were used to measure anxiety- and depressive-like behaviors in FlxGluN2D mice with bilateral intra-dlBNST injections of Cre recombinase- or GFP-expressing virus, and we found that conditional knockdown of dlBNST GluN2D in female mice does not affect these assays of negative affect. However, in a continuous access ethanol two-bottle choice task, preliminary data suggest that female mice lacking dlBNST GluN2D display decreased ethanol intake and preference across the six-week paradigm as well as during an assessment of aversion-resistant ethanol intake, using increasing concentrations of quinine in the ethanol. These data propose a role for dlBNST GluN2D expression in mediating ethanol-related behaviors. However, as the BNST is a highly heterogenous region, it remains unknown if neuronal subpopulations drive changes in expression. Notably, BNST neurons expressing corticotropin-releasing factor (BNST^CRF) have been implicated in both negative affect and stress-induced alcohol-seeking behaviors and exhibit a significant level of <i>grin2d</i> labeling. Current studies investigate counts of <i>grin2d</i> puncta in BNST^CRF cells following protracted withdrawal in the CDFA paradigm. In addition to regulation of subunit expression by forced abstinence, parallel studies investigate the role of GluN2D-containing NMDARs in modifying ethanol sensitivity of BNST^CRFneurons. Together, given the restricted CNS expression of this subunit, exploration of GluN2D control of ethanol circuit actions may lead to a novel therapeutic target to consider in AUD treatment. MAD was supported by T32s (T32 NS007491 and T32 MH065215) and an F32 from NIAAA (MAD, AA029592). The research was supported by an R37 from NIAAA (DGW, AA019455)." @default.
• W4377029104 created "2023-05-19" @default.
• W4377029104 creator A5004057474 @default.
• W4377029104 creator A5005497098 @default.
• W4377029104 creator A5015962027 @default.
• W4377029104 creator A5016281292 @default.
• W4377029104 creator A5019806332 @default.
• W4377029104 creator A5028642381 @default.
• W4377029104 creator A5044194553 @default.
• W4377029104 creator A5074875737 @default.
• W4377029104 creator A5091973937 @default.
• W4377029104 date "2023-05-18" @default.
• W4377029104 modified "2023-09-29" @default.
• W4377029104 title "Role and Regulation of BNST GluN2D-containing NMDARs in a Continuous Access Ethanol Task" @default.
• W4377029104 doi "https://doi.org/10.1124/jpet.122.165150" @default.
• W4377029104 hasPublicationYear "2023" @default.
• W4377029104 type Work @default.
• W4377029104 citedByCount "0" @default.
• W4377029104 crossrefType "proceedings-article" @default.
• W4377029104 hasAuthorship W4377029104A5004057474 @default.
• W4377029104 hasAuthorship W4377029104A5005497098 @default.
• W4377029104 hasAuthorship W4377029104A5015962027 @default.
• W4377029104 hasAuthorship W4377029104A5016281292 @default.
• W4377029104 hasAuthorship W4377029104A5019806332 @default.
• W4377029104 hasAuthorship W4377029104A5028642381 @default.
• W4377029104 hasAuthorship W4377029104A5044194553 @default.
• W4377029104 hasAuthorship W4377029104A5074875737 @default.
• W4377029104 hasAuthorship W4377029104A5091973937 @default.
• W4377029104 hasBestOaLocation W43770291041 @default.
• W4377029104 hasConcept C126322002 @default.
• W4377029104 hasConcept C134018914 @default.
• W4377029104 hasConcept C151730666 @default.
• W4377029104 hasConcept C15744967 @default.
• W4377029104 hasConcept C169760540 @default.
• W4377029104 hasConcept C2776035688 @default.
• W4377029104 hasConcept C2778652331 @default.
• W4377029104 hasConcept C2779144063 @default.
• W4377029104 hasConcept C2779343474 @default.
• W4377029104 hasConcept C2779442783 @default.
• W4377029104 hasConcept C2780948618 @default.
• W4377029104 hasConcept C2781066024 @default.
• W4377029104 hasConcept C46312422 @default.
• W4377029104 hasConcept C55493867 @default.
• W4377029104 hasConcept C71924100 @default.
• W4377029104 hasConcept C86803240 @default.
• W4377029104 hasConceptScore W4377029104C126322002 @default.
• W4377029104 hasConceptScore W4377029104C134018914 @default.
• W4377029104 hasConceptScore W4377029104C151730666 @default.
• W4377029104 hasConceptScore W4377029104C15744967 @default.
• W4377029104 hasConceptScore W4377029104C169760540 @default.
• W4377029104 hasConceptScore W4377029104C2776035688 @default.
• W4377029104 hasConceptScore W4377029104C2778652331 @default.
• W4377029104 hasConceptScore W4377029104C2779144063 @default.
• W4377029104 hasConceptScore W4377029104C2779343474 @default.
• W4377029104 hasConceptScore W4377029104C2779442783 @default.
• W4377029104 hasConceptScore W4377029104C2780948618 @default.
• W4377029104 hasConceptScore W4377029104C2781066024 @default.
• W4377029104 hasConceptScore W4377029104C46312422 @default.
• W4377029104 hasConceptScore W4377029104C55493867 @default.
• W4377029104 hasConceptScore W4377029104C71924100 @default.
• W4377029104 hasConceptScore W4377029104C86803240 @default.
• W4377029104 hasLocation W43770291041 @default.
• W4377029104 hasOpenAccess W4377029104 @default.
• W4377029104 hasPrimaryLocation W43770291041 @default.
• W4377029104 hasRelatedWork W1488326036 @default.
• W4377029104 hasRelatedWork W1922944626 @default.
• W4377029104 hasRelatedWork W1984439683 @default.
• W4377029104 hasRelatedWork W2014711623 @default.
• W4377029104 hasRelatedWork W2068991783 @default.
• W4377029104 hasRelatedWork W2085601345 @default.
• W4377029104 hasRelatedWork W2094498137 @default.
• W4377029104 hasRelatedWork W2140288223 @default.
• W4377029104 hasRelatedWork W2165709961 @default.
• W4377029104 hasRelatedWork W2944540470 @default.
• W4377029104 isParatext "false" @default.
• W4377029104 isRetracted "false" @default.
• W4377029104 workType "article" @default.