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- W4377029305 abstract "<b>Abstract ID 26311</b> <b>Poster Board 268</b> Homeostatic regulation of food consumption and stress is critical to survival, yet certain environmental conditions facilitate aberrant feeding behaviors. Nociceptin and its receptor, nociceptin opioid peptide (NOP) receptor have a vast neuromodulatory network spanning multiple stress and reward-related brain nuclei and have been demonstrated to modulate feeding and stress regulation. Previous data has shown that stimulation of nociceptin-expressing neurons in the arcuate nucleus of the hypothalamus (ARC) increases food consumption. Similarly, stimulation of these neurons afferent projections within the bed nucleus of the stria terminalis (BNST) also increases food consumption. Here, we examined how this nociceptinergic neruocircuitry controls palatable food consumption in a model of stress-induced binge eating behavior where animals are given intermittent food restriction and palatable food access similar to yo-yo dieting. We used inhibitory opsin, parapinopsin (PPO) in Pnoc-Cre mice to inhibit nociceptin-expressing ARC projections in the BNST during food stress and palatable food access. We found that BNST-afferent ARC<sup>Pnoc</sup> neuron inhibition reduces stress-induced food consumption in animals previously exposed to cycles of food restriction and ad libitum palatable food access. Supported by NIH grant P30 DK056341 (Nutrition Obesity Research Center)" @default.
- W4377029305 created "2023-05-19" @default.
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- W4377029305 date "2023-05-18" @default.
- W4377029305 modified "2023-09-26" @default.
- W4377029305 title "Hypothalamic nociceptin neurons modulate stress-induced binge eating behaviors" @default.
- W4377029305 doi "https://doi.org/10.1124/jpet.122.263110" @default.
- W4377029305 hasPublicationYear "2023" @default.
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