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- W4377029349 abstract "<b>Abstract ID 24830</b> <b>Poster Board 66</b> Michael Ippolito, Hajra Sohail, Ian Barckhausen, Eleanor Labriola, Sara Jane Ward Neuropathic pain is a form of chronic pain that develops as a consequence of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most of the available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant potential for addiction and abuse. Thus, neuropathic pain represents an area of critical unmet medical need to be addressed by the global medical and pharmaceutical communities. Novel classes of therapeutics with improved efficacy and safety profiles are urgently needed for the treatment of neuropathic pain. Novel antagonist of GPR55, KLS-13019, was screened in rat models of neuropathic pain and morphine discrimination. Peripheral neuropathy was induced in 16 rats with once daily 1mg/kg paclitaxel injections for 4 days. Rats were then administered 0, 3, 10, or 30 mg/kg KLS-13019 on days 7 and 14 and allodynia was assessed by a Von Frey test. Allodynia was reversed in a dose dependent manner in the rats treated with KLS-13019, with the highest dose reverting the response to pre-paclitaxel injection baseline levels. Additionally, in an effort to characterize the in vivo pharmacology of KLS-13019 compared to opioid-class drugs, a cohort of rats was trained to discriminate between morphine and saline via alternative and mutually exclusive lever presses as the “correct response” to treatment. After training, rats dosed with KLS-13109 did not respond as though they had received morphine. Together, these data suggest that KLS-13019 represents a new class of drug that would be potentially useful for the treatment of neuropathic pain, and these animal models in combination with molecular techniques will describe the role of GPR55 in neuropathic pain to provide the proof-of-concept for a novel therapeutic strategy for this affliction." @default.
- W4377029349 created "2023-05-19" @default.
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- W4377029349 date "2023-05-18" @default.
- W4377029349 modified "2023-09-29" @default.
- W4377029349 title "GPR55 Antagonist KLS-13019 Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats" @default.
- W4377029349 doi "https://doi.org/10.1124/jpet.122.248300" @default.
- W4377029349 hasPublicationYear "2023" @default.
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