FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029462> ?p ?o ?g. }

• W4377029462 abstract "<b>Abstract ID 22614</b> <b>Poster Board 22</b> Cancer continues to represent a major contributor to morbidity and mortality worldwide. Despite the efficacy of conventional chemotherapy in abrogating tumor growth, these agents can also impact normal tissue, resulting in multiple treatment-limiting adverse effects. In addition to causing peripheral neuronal dysfunction, chemotherapy can also affect the function of central nervous system (CNS), causing significant cognitive dysfunction, difficulties with memory, thinking clearly, and increased anxiety. These heterogeneous group of central abnormalities are often described as post-chemotherapy-induced cognitive dysfunction, “chemofog”, or more commonly, “chemobrain”. Unfortunately, an exact pathophysiology and effective treatment for chemobrain are both lacking. Thus, this study aimed to investigate the short- and long-term effects of doxorubicin (DOX) and paclitaxel (PAC) on learning and memory in rats using radial arm water maze (RAWM). Also, we evaluated the possible beneficial effect of Vitamin E (as antioxidant vitamin) on DOX- and PAC-induced cognitive impairment. Adult male rats were injected with 4 doses of 2 mg/kg/week DOX (or its vehicle) or 2 mg/kg PAC (or its vehicles) every other day intraperitoneally. Vitamin E or its vehicle was co-administered with these drugs in other groups to study its antioxidative effects in the brain. Using radial arm water maze, each rat was assessed for learning and memory performance through two sets of six trials separated by a 5-minute rest period. These 12 trials were followed by a 30-minute trial (13^th trial) to evaluate short-term memory and two long-term memory trials after 5 and 24 hours (14^th + 15^th trials). At the end of the treatment period and behavioral tests, all animals were decapitated., and the brain was promptly dissected, and hippocampal tissue was extracted for chemical analysis. TBARS and BDNF levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Our results showed that there is no deficit in learning or long-term memory in both DOX and PAC groups compared to the control group. However, rats in the DOX or the PAC groups made significantly more errors in all short-term memory trials (trials after 30 minutes) than the other groups. This effect was improved in groups where Vit. E was co-administered with either DOX or PAC. PAC (but not DOX) was able to induce hippocampal lipid peroxidation as indicated by increasing the levels of standard biomarker thiobarbituric acid reactive substances (TBARs). Interestingly, the co-administration of Vit. E resulted in the reversal of PAC-induced hippocampal oxidative stress. Moreover, both DOX and PAC exposure reduced BDNF expression in the hippocampus, which was overcome by the co-administration of Vit. E. Our results indicate a potential role of Vit. E in mitigating short-term memory impairment in rats exposed to chemotherapy, possibly due to the reduction in hippocampal oxidative stress and neurodegeneration. <b>Support/Funding Information:</b> Deanship of Research, Jordan University of Science and Technology (Grant number 2021/109)" @default.
• W4377029462 created "2023-05-19" @default.
• W4377029462 creator A5011138377 @default.
• W4377029462 creator A5031813919 @default.
• W4377029462 creator A5049884448 @default.
• W4377029462 creator A5078571712 @default.
• W4377029462 creator A5091974026 @default.
• W4377029462 creator A5091974027 @default.
• W4377029462 date "2023-05-18" @default.
• W4377029462 modified "2023-09-29" @default.
• W4377029462 title "Effect of Vitamin E on Doxorubicin and Paclitaxel Induced Memory Impairments in Male Rats" @default.
• W4377029462 doi "https://doi.org/10.1124/jpet.122.226140" @default.
• W4377029462 hasPublicationYear "2023" @default.
• W4377029462 type Work @default.
• W4377029462 citedByCount "0" @default.
• W4377029462 crossrefType "proceedings-article" @default.
• W4377029462 hasAuthorship W4377029462A5011138377 @default.
• W4377029462 hasAuthorship W4377029462A5031813919 @default.
• W4377029462 hasAuthorship W4377029462A5049884448 @default.
• W4377029462 hasAuthorship W4377029462A5078571712 @default.
• W4377029462 hasAuthorship W4377029462A5091974026 @default.
• W4377029462 hasAuthorship W4377029462A5091974027 @default.
• W4377029462 hasBestOaLocation W43770294621 @default.
• W4377029462 hasConcept C118552586 @default.
• W4377029462 hasConcept C12515866 @default.
• W4377029462 hasConcept C126322002 @default.
• W4377029462 hasConcept C13260007 @default.
• W4377029462 hasConcept C169900460 @default.
• W4377029462 hasConcept C173586616 @default.
• W4377029462 hasConcept C197934379 @default.
• W4377029462 hasConcept C21963081 @default.
• W4377029462 hasConcept C2776694085 @default.
• W4377029462 hasConcept C2777292972 @default.
• W4377029462 hasConcept C2777551382 @default.
• W4377029462 hasConcept C2778004101 @default.
• W4377029462 hasConcept C2781161787 @default.
• W4377029462 hasConcept C2781303535 @default.
• W4377029462 hasConcept C3018842126 @default.
• W4377029462 hasConcept C42219234 @default.
• W4377029462 hasConcept C44752575 @default.
• W4377029462 hasConcept C529278444 @default.
• W4377029462 hasConcept C55493867 @default.
• W4377029462 hasConcept C558461103 @default.
• W4377029462 hasConcept C71924100 @default.
• W4377029462 hasConcept C86803240 @default.
• W4377029462 hasConcept C98274493 @default.
• W4377029462 hasConceptScore W4377029462C118552586 @default.
• W4377029462 hasConceptScore W4377029462C12515866 @default.
• W4377029462 hasConceptScore W4377029462C126322002 @default.
• W4377029462 hasConceptScore W4377029462C13260007 @default.
• W4377029462 hasConceptScore W4377029462C169900460 @default.
• W4377029462 hasConceptScore W4377029462C173586616 @default.
• W4377029462 hasConceptScore W4377029462C197934379 @default.
• W4377029462 hasConceptScore W4377029462C21963081 @default.
• W4377029462 hasConceptScore W4377029462C2776694085 @default.
• W4377029462 hasConceptScore W4377029462C2777292972 @default.
• W4377029462 hasConceptScore W4377029462C2777551382 @default.
• W4377029462 hasConceptScore W4377029462C2778004101 @default.
• W4377029462 hasConceptScore W4377029462C2781161787 @default.
• W4377029462 hasConceptScore W4377029462C2781303535 @default.
• W4377029462 hasConceptScore W4377029462C3018842126 @default.
• W4377029462 hasConceptScore W4377029462C42219234 @default.
• W4377029462 hasConceptScore W4377029462C44752575 @default.
• W4377029462 hasConceptScore W4377029462C529278444 @default.
• W4377029462 hasConceptScore W4377029462C55493867 @default.
• W4377029462 hasConceptScore W4377029462C558461103 @default.
• W4377029462 hasConceptScore W4377029462C71924100 @default.
• W4377029462 hasConceptScore W4377029462C86803240 @default.
• W4377029462 hasConceptScore W4377029462C98274493 @default.
• W4377029462 hasLocation W43770294621 @default.
• W4377029462 hasOpenAccess W4377029462 @default.
• W4377029462 hasPrimaryLocation W43770294621 @default.
• W4377029462 hasRelatedWork W1964503813 @default.
• W4377029462 hasRelatedWork W1991932902 @default.
• W4377029462 hasRelatedWork W2046652694 @default.
• W4377029462 hasRelatedWork W2050742519 @default.
• W4377029462 hasRelatedWork W2052922321 @default.
• W4377029462 hasRelatedWork W2053436208 @default.
• W4377029462 hasRelatedWork W2116798122 @default.
• W4377029462 hasRelatedWork W2155481114 @default.
• W4377029462 hasRelatedWork W4281257783 @default.
• W4377029462 hasRelatedWork W4385284967 @default.
• W4377029462 isParatext "false" @default.
• W4377029462 isRetracted "false" @default.
• W4377029462 workType "article" @default.