FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029603> ?p ?o ?g. }

• W4377029603 abstract "<b>Abstract ID 23079</b> <b>Poster Board 212</b> Neuronal disturbances signify brain vulnerability that fosters cognitive impairment, whether facilitated by excitatory over-activation, toxin exposures, metabolic distress, trauma-inducing events, or aging. Across such dementia risk factors, negative effects on proteostasis and synaptic integrity gradually increase the risk for mild cognitive impairment (MCI) and the continuum to dementia. Removal of old and damaged proteins by the autophagy-lysosomal pathway clearly becomes compromised with aging, and the altered proteostasis has been linked to the gradual deterioration of synaptic connections important for cognition. Poor nutrition is known to impact cognition and many studies suggest natural products promote cognitive health. Here, a dozen natural products were tested for their ability to amplify cathepsin B (CatB), a lysosomal enzyme that has been found to degrade pathogenic proteins and to be synaptoprotective in models of aging-related neurodegenerative disorders. After three daily infusions into hippocampal explants, extracts of bacopa (<i>Bacopa monnieri</i>) and the specific ginseng <i>Panax quinquefolius</i> enhanced the 30-kDa active form of the CatB protease (CatB-30) by over 3-fold, whereas only small increases were produced by another ginseng extract (<i>Panax ginseng</i>) and wild blueberry extract (<i>Vaccinium</i><i>corymbosum</i>). Only <i>P. quinquefolius</i> treatment produced a correlation between enhanced CatB-30 levels and levels of the synaptic proteins GluA1 and synaptophysin. This ginseng extract was also the most effective natural product tested for increasing the autophagy marker LC3-II. To further address the hypothesis that dietary agents activate the CatB autophagy-lysosomal component and enhance synaptic resilience, we tested plant extracts and the exercise mimetic β-GPA in long-term hippocampal slice cultures subjected to a week of proteostatic stress induced by the lysosomotropic compound chloroquine. Note that, similar to the benefits of a healthy diet, exercise is well-known for reducing dementia risk, and the exercise mimetic β-GPA was previously shown in our lab to positively modulate the CatB protease. In the chloroquine-insulted tissue, both <i>P.quinquefolius</i> and β-GPA treatments resulted in significant protection of hippocampal synapses, and <i>V.</i><i>corymbosum</i> extract protected marginally. These results indicate synaptic resilience as being a key factor for brain health through diet and exercise. In recent <i>in vivo</i> studies, our translational research identified selective cognitive defects in middle-aged rodents as compared to respective young groups, and the aging-induced cognitive decline was offset by two tested treatments. The same ginseng extract found to be an effective CatB positive modulator improved behavioral performance in middle-aged Fisher rats (12 months) when supplemented into supplied food pellets for 6 weeks. In a separate study, β-GPA was found to enhanced memory in 10-month-old mice when supplemented into a 6-week feeding schedule. Interestingly, the commonality the two agents have for reducing the aging-related cognitive deficits is similar to the common modulation the agents elicit towards key elements of the autophagy-lysosomal system." @default.
• W4377029603 created "2023-05-19" @default.
• W4377029603 creator A5020704914 @default.
• W4377029603 creator A5030344878 @default.
• W4377029603 creator A5038783850 @default.
• W4377029603 date "2023-05-18" @default.
• W4377029603 modified "2023-09-29" @default.
• W4377029603 title "Commonalities of Ginseng Extract (P. quinquefolius) and Exercise Mimetic β-GPA for Reducing Age-related Cognitive Deficits and Modulating the Autophagy-Lysosomal Pathway" @default.
• W4377029603 doi "https://doi.org/10.1124/jpet.122.230790" @default.
• W4377029603 hasPublicationYear "2023" @default.
• W4377029603 type Work @default.
• W4377029603 citedByCount "0" @default.
• W4377029603 crossrefType "proceedings-article" @default.
• W4377029603 hasAuthorship W4377029603A5020704914 @default.
• W4377029603 hasAuthorship W4377029603A5030344878 @default.
• W4377029603 hasAuthorship W4377029603A5038783850 @default.
• W4377029603 hasBestOaLocation W43770296031 @default.
• W4377029603 hasConcept C126322002 @default.
• W4377029603 hasConcept C142724271 @default.
• W4377029603 hasConcept C181199279 @default.
• W4377029603 hasConcept C190283241 @default.
• W4377029603 hasConcept C203522944 @default.
• W4377029603 hasConcept C204787440 @default.
• W4377029603 hasConcept C2776539398 @default.
• W4377029603 hasConcept C2779134260 @default.
• W4377029603 hasConcept C2779232237 @default.
• W4377029603 hasConcept C2779483572 @default.
• W4377029603 hasConcept C2781452922 @default.
• W4377029603 hasConcept C28021979 @default.
• W4377029603 hasConcept C2984863031 @default.
• W4377029603 hasConcept C55493867 @default.
• W4377029603 hasConcept C71924100 @default.
• W4377029603 hasConcept C86803240 @default.
• W4377029603 hasConcept C95444343 @default.
• W4377029603 hasConcept C98274493 @default.
• W4377029603 hasConceptScore W4377029603C126322002 @default.
• W4377029603 hasConceptScore W4377029603C142724271 @default.
• W4377029603 hasConceptScore W4377029603C181199279 @default.
• W4377029603 hasConceptScore W4377029603C190283241 @default.
• W4377029603 hasConceptScore W4377029603C203522944 @default.
• W4377029603 hasConceptScore W4377029603C204787440 @default.
• W4377029603 hasConceptScore W4377029603C2776539398 @default.
• W4377029603 hasConceptScore W4377029603C2779134260 @default.
• W4377029603 hasConceptScore W4377029603C2779232237 @default.
• W4377029603 hasConceptScore W4377029603C2779483572 @default.
• W4377029603 hasConceptScore W4377029603C2781452922 @default.
• W4377029603 hasConceptScore W4377029603C28021979 @default.
• W4377029603 hasConceptScore W4377029603C2984863031 @default.
• W4377029603 hasConceptScore W4377029603C55493867 @default.
• W4377029603 hasConceptScore W4377029603C71924100 @default.
• W4377029603 hasConceptScore W4377029603C86803240 @default.
• W4377029603 hasConceptScore W4377029603C95444343 @default.
• W4377029603 hasConceptScore W4377029603C98274493 @default.
• W4377029603 hasLocation W43770296031 @default.
• W4377029603 hasOpenAccess W4377029603 @default.
• W4377029603 hasPrimaryLocation W43770296031 @default.
• W4377029603 hasRelatedWork W1045058699 @default.
• W4377029603 hasRelatedWork W2036681019 @default.
• W4377029603 hasRelatedWork W2324862512 @default.
• W4377029603 hasRelatedWork W2689973854 @default.
• W4377029603 hasRelatedWork W2952944117 @default.
• W4377029603 hasRelatedWork W2963720443 @default.
• W4377029603 hasRelatedWork W2994792393 @default.
• W4377029603 hasRelatedWork W4224243709 @default.
• W4377029603 hasRelatedWork W4225409169 @default.
• W4377029603 hasRelatedWork W4311829228 @default.
• W4377029603 isParatext "false" @default.
• W4377029603 isRetracted "false" @default.
• W4377029603 workType "article" @default.