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• W4377029672 abstract "<b>Abstract ID 23235</b> <b>Poster Board 206</b> We sought to determine if medications used as atypical antipsychotics in humans affect food-related discriminative stimuli in adult and aged animals. We examined the ability of the atypical antipsychotics clozapine and ziprasidone to alter discriminative stimuli associated with 22 hr food deprivation. Rats were trained to discriminate between 22 and 2 hours food deprivation in an operant choice procedure. Under 22 hr deprivation conditions, left lever presses were reinforced with the delivery of a 45 mg food pellet under a Fixed Ratio 15 reinforcement schedule (FR 15). Incorrect lever presses induced 8 seconds of darkness under the FR 15. Experimental contingencies were reversed under 2 hr deprivation conditions. Training continued until rats emitted 80% or greater condition-appropriate responses both before the first consequence and for the entire training session (10 reinforcers earned of 15 minutes elapsed) for 8 out of 10 consecutive sessions. After acquisition of the discrimination, tests sessions began. During test sessions, responses to both levers were reinforced under FR 15s and 5 reinforcers could be earned in a 5 minute trial. Test trials were conducted every 15 minutes for 2 hours. Test sessions were preceded by subcutaneous injection of vehicle, clozapine (1.0-5.6 mg/kg), or ziprasidone (0.1 to 1.0 mg/kg). Under 2 hr deprivation condition, atypical antipsychotic pretreatment did not induce 22-hr deprivation-like responding (e.g., the drug did not induce stimuli associated with “hunger”). Under 22 hr deprivation conditions, clozapine reduced the discriminative stimulus effects of food deprivation (1.0 – 5.6 mg/kg) and reduced rates of lever pressing (5.6 mg/kg). Under both 2 and 22 hr food deprivation conditions, clozapine reduced food intake (3.2 -5.6 mg/kg). The effects of clozapine were assessed again six months later. Clozapine (1.0 mg/kg) produced rate decreasing effects and eliminated responding in several subjects. At time points where rates were not suppressed, the discriminative stimulus effects of 22 hr deprivation were not altered. Later, the effects of ziprasidone were assessed. Ziprasidone did not alter discriminative stimuli associated with 22 hr food deprivation or reduce 22 hr deprivation-induced food intake. Ziprasidone (1.0 mg/kg) significantly reduced rates of lever pressing. We noticed differences in the stability of the discriminative stimulus effects of 22 hr deprivation during the test sessions. With younger subjects (age ∼ 12 months) and under conditions with the vehicle for clozapine (30% DMSO), the discriminative stimulus effects of 22 hr food deprivation were stable for the entire 2 hr session (on average, performance was not different than criterion levels). In older subjects (∼24 months) administered with the vehicle for ziprasidone, test performance was less stable, especially during the second hour of assessment. Initial assessments of accuracy during training sessions have not revealed differences in performance between ∼12 month old subjects and ∼24 month old subjects. Medications used as atypical antipsychotics can have different effects in rodent models of eating. Clozapine, but not ziprasidone, reduced both 22 hr deprivation-induced discriminative stimuli and 22 hr deprivation-induced food intake. Clozapine’s rate decreasing effects were more pronounced in older rats. The deprivation discrimination can be used to assess food-related phenomenon throughout the life span of rodents." @default.
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• W4377029672 date "2023-05-18" @default.
• W4377029672 modified "2023-09-27" @default.
• W4377029672 title "Clozapine, but Not Ziprasidone, Decreases the Discriminative Stimulus Effects of 22 Hours Deprivation in Sprague-Dawley Rats" @default.
• W4377029672 doi "https://doi.org/10.1124/jpet.122.232350" @default.
• W4377029672 hasPublicationYear "2023" @default.
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