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- W4377029692 abstract "<b>Abstract ID 56700</b> <b>Poster Board 17</b> Methamphetamine is a highly addictive psychostimulant that upon chronic use can be associated with maladaptive behavior and cognitive impairment. Methamphetamine is almost equally used by both sexes; however, little has been done thus far to investigate the influence of sex on behavioral outcomes associated with chronic methamphetamine use. Likewise, methamphetamine can be administered through various routes, with the most popular being inhalation, but another common route being intravenous injections. We aimed to investigate how route of administration and sex influence behavioral outcomes, subjects (N = 49) were recruited from local in-patient addiction treatment facilities, and once consented, screened, and determined eligible for participation, subjects completed questionnaires about their drug use history as well as a cognitive battery including tasks of various executive functions such as cognitive flexibility and response inhibition. At the group level, there was no difference in task performance between males and females. Interestingly, when route of administration was considered, only females were affected, such that females who administer methamphetamine intravenously performed worse on cognitive tasks than females who inhale methamphetamine. Male methamphetamine users, however, did not exhibit this same pattern. Route of methamphetamine administration did not affect task performance in males. These results suggest that males and females are differentially affected by drug use patterns, and therefore should be managed differently in treatment. Further research should be to characterize this phenomenon of sex differences revealed by route of administration’s impact on executive function tasks. Including neuroimaging in future studies will be important in fully characterizing this sex difference found with route of methamphetamine administration. This work was supported by the Louisiana Addiction Research Center, the LSU Health Shreveport Office of Research, the Department of Pharmacology, Toxicology & Neuroscience, and the Center of Biomedical Research Excellence in Redox Biology and Cardiovascular Disease (P20GM121307)." @default.
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- W4377029692 date "2023-05-18" @default.
- W4377029692 modified "2023-10-06" @default.
- W4377029692 title "Methamphetamine Route of Administration has a Disproportionate Impact on Females than Males" @default.
- W4377029692 doi "https://doi.org/10.1124/jpet.122.567000" @default.
- W4377029692 hasPublicationYear "2023" @default.
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