Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029695> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4377029695 abstract "Abstract Background: Critical illness polyneuropathy (CIP) is a frequent and underdiagnosed phenomenon among intensive care unit patients. The lipophilic nature of neuronal synapses may result in the association of low serum cholesterol levels with a higher rate of CIP development. We aimed to investigate this issue in critically ill patients. Methods: All cases diagnosed with CIP in our tertiary care hospital between 2013 and 2017 were 1:1 matched with controls without the condition by age, sex, and ICD diagnoses. The main risk factor examined was the difference between initial and minimum serum cholesterol levels. Other predictors were serum markers of acute inflammation. Results: We included 67 cases and 67 controls (134 critically ill patients, 49% female, 46% medical). Minimum serum cholesterol levels were lower in the cases (median difference: -24, 95% CI [-39, -9], mg/dl). A conditional logistic regression model controlling for the patients’ length of CCU stay showed a 2.2% increase in odds (odds ratio 1.022, 95% CI [1.006, 1.037], p=0.007) for the development of CIP for every 1 mg/dl decrease in serum cholesterol levels between the initial and lowest serum concentrations. Cholesterol levels decreased more profoundly in cases than controls (median: -74 (IQR -115 to -24) vs. ‑22 (IQR -53 to 0), median difference: -36, 95% CI [-59, -13]), mg/dl). We found significant median differences across matched pairs in maximum serum C-reactive protein (8.9, 95% CI [4.56, 13.24], mg/dl), minimum albumin (-4.2, 95% CI [-6.7, -1.7], g/l) and lowest cholinesterase levels (-0.72, 95% CI [-1.05, -0.39], U/l). Conclusion: Lower minimum cholesterol levels and more pronounced decreases in cholesterol levels during critical care unit hospitalizations may be a risk factor for CIP." @default.
- W4377029695 created "2023-05-19" @default.
- W4377029695 creator A5006437226 @default.
- W4377029695 creator A5034197878 @default.
- W4377029695 creator A5037228297 @default.
- W4377029695 creator A5051293768 @default.
- W4377029695 creator A5051922665 @default.
- W4377029695 creator A5060011526 @default.
- W4377029695 creator A5064021607 @default.
- W4377029695 creator A5083040991 @default.
- W4377029695 creator A5091809236 @default.
- W4377029695 creator A5091974105 @default.
- W4377029695 date "2023-05-18" @default.
- W4377029695 modified "2023-09-30" @default.
- W4377029695 title "Lower Serum Cholesterol Levels as a Risk Factor for Critical Illness Polyneuropathy: A matched Case-Control Study" @default.
- W4377029695 cites W1905045541 @default.
- W4377029695 cites W1970541648 @default.
- W4377029695 cites W1974754952 @default.
- W4377029695 cites W1976931622 @default.
- W4377029695 cites W1977493330 @default.
- W4377029695 cites W1980168675 @default.
- W4377029695 cites W1999874283 @default.
- W4377029695 cites W2000726602 @default.
- W4377029695 cites W2017827719 @default.
- W4377029695 cites W2021222203 @default.
- W4377029695 cites W2034978050 @default.
- W4377029695 cites W2043815129 @default.
- W4377029695 cites W2075179703 @default.
- W4377029695 cites W2106897142 @default.
- W4377029695 cites W2127927152 @default.
- W4377029695 cites W2156779372 @default.
- W4377029695 cites W2295169366 @default.
- W4377029695 cites W2946938967 @default.
- W4377029695 cites W299349441 @default.
- W4377029695 cites W3178268757 @default.
- W4377029695 doi "https://doi.org/10.21203/rs.3.rs-2906346/v1" @default.
- W4377029695 hasPublicationYear "2023" @default.
- W4377029695 type Work @default.
- W4377029695 citedByCount "0" @default.
- W4377029695 crossrefType "posted-content" @default.
- W4377029695 hasAuthorship W4377029695A5006437226 @default.
- W4377029695 hasAuthorship W4377029695A5034197878 @default.
- W4377029695 hasAuthorship W4377029695A5037228297 @default.
- W4377029695 hasAuthorship W4377029695A5051293768 @default.
- W4377029695 hasAuthorship W4377029695A5051922665 @default.
- W4377029695 hasAuthorship W4377029695A5060011526 @default.
- W4377029695 hasAuthorship W4377029695A5064021607 @default.
- W4377029695 hasAuthorship W4377029695A5083040991 @default.
- W4377029695 hasAuthorship W4377029695A5091809236 @default.
- W4377029695 hasAuthorship W4377029695A5091974105 @default.
- W4377029695 hasBestOaLocation W43770296951 @default.
- W4377029695 hasConcept C126322002 @default.
- W4377029695 hasConcept C146304588 @default.
- W4377029695 hasConcept C151956035 @default.
- W4377029695 hasConcept C156957248 @default.
- W4377029695 hasConcept C165616093 @default.
- W4377029695 hasConcept C2776376669 @default.
- W4377029695 hasConcept C2778163477 @default.
- W4377029695 hasConcept C50440223 @default.
- W4377029695 hasConcept C71924100 @default.
- W4377029695 hasConcept C90924648 @default.
- W4377029695 hasConceptScore W4377029695C126322002 @default.
- W4377029695 hasConceptScore W4377029695C146304588 @default.
- W4377029695 hasConceptScore W4377029695C151956035 @default.
- W4377029695 hasConceptScore W4377029695C156957248 @default.
- W4377029695 hasConceptScore W4377029695C165616093 @default.
- W4377029695 hasConceptScore W4377029695C2776376669 @default.
- W4377029695 hasConceptScore W4377029695C2778163477 @default.
- W4377029695 hasConceptScore W4377029695C50440223 @default.
- W4377029695 hasConceptScore W4377029695C71924100 @default.
- W4377029695 hasConceptScore W4377029695C90924648 @default.
- W4377029695 hasLocation W43770296951 @default.
- W4377029695 hasOpenAccess W4377029695 @default.
- W4377029695 hasPrimaryLocation W43770296951 @default.
- W4377029695 hasRelatedWork W1973097496 @default.
- W4377029695 hasRelatedWork W2014963733 @default.
- W4377029695 hasRelatedWork W2041109271 @default.
- W4377029695 hasRelatedWork W2062988031 @default.
- W4377029695 hasRelatedWork W2109365352 @default.
- W4377029695 hasRelatedWork W2164301666 @default.
- W4377029695 hasRelatedWork W2350415074 @default.
- W4377029695 hasRelatedWork W2351580218 @default.
- W4377029695 hasRelatedWork W3031421533 @default.
- W4377029695 hasRelatedWork W4377029695 @default.
- W4377029695 isParatext "false" @default.
- W4377029695 isRetracted "false" @default.
- W4377029695 workType "article" @default.