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• W4377029773 abstract "Antibodies, through their ability to target virtually any epitope, play a key role in driving the adaptive immune response in jawed vertebrates. The binding domains of standard antibodies are their variable light (V L ) and heavy (V H ) domains, both of which present analogous complementarity-determining region (CDR) loops. It has long been known that the V H CDRs contribute more heavily to the antigen-binding surface (paratope), with the CDR-H3 loop providing a major modality for the generation of diverse paratopes. Here, we provide evidence for an additional role of the V L domain as a modulator of CDR-H3 structure, using a diverse set of antibody crystal structures and a large set of molecular dynamics simulations. We show that specific attributes of the V L domain such as CDR canonical forms and genes can influence the structural diversity of the CDR-H3 loop, and provide a physical model for how this effect occurs through inter-loop contacts and packing of CDRs against each other. Our study provides insights into the interdependent nature of CDR conformations, an understanding of which is important for the rational antibody design process." @default.
• W4377029773 created "2023-05-19" @default.
• W4377029773 creator A5015572211 @default.
• W4377029773 creator A5061280509 @default.
• W4377029773 date "2023-05-18" @default.
• W4377029773 modified "2023-10-02" @default.
• W4377029773 title "Specific attributes of the V_Ldomain influence both the structure and structural variability of CDR-H3 through steric effects" @default.
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• W4377029773 doi "https://doi.org/10.1101/2023.05.16.540974" @default.
• W4377029773 hasPublicationYear "2023" @default.
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