Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029863> ?p ?o ?g. }
- W4377029863 abstract "Abstract Mixed phenotype acute leukemia (MPAL) is a leukemia whose biologic drivers are poorly understood, therapeutic strategy remains unclear, and prognosis is poor. We performed multiomic single cell (SC) profiling of 14 newly diagnosed adult MPAL patients to characterize the immunophenotypic, genetic, and transcriptional landscapes of MPAL. We show that neither genetic profile nor transcriptome reliably correlate with specific MPAL immunophenotypes. However, progressive acquisition of mutations is associated with increased expression of immunophenotypic markers of immaturity. Using SC transcriptional profiling, we find that MPAL blasts express a stem cell-like transcriptional profile distinct from other acute leukemias and indicative of high differentiation potential. Further, patients with the highest differentiation potential demonstrated inferior survival in our dataset. A gene set score, MPAL95, derived from genes highly enriched in this cohort, is applicable to bulk RNA sequencing data and was predictive of survival in an independent patient cohort, suggesting utility for clinical risk stratification." @default.
- W4377029863 created "2023-05-19" @default.
- W4377029863 creator A5000081957 @default.
- W4377029863 creator A5004828733 @default.
- W4377029863 creator A5006697675 @default.
- W4377029863 creator A5007408598 @default.
- W4377029863 creator A5014630772 @default.
- W4377029863 creator A5016883047 @default.
- W4377029863 creator A5021636620 @default.
- W4377029863 creator A5034417710 @default.
- W4377029863 creator A5037460404 @default.
- W4377029863 creator A5051004969 @default.
- W4377029863 creator A5055064927 @default.
- W4377029863 creator A5056892173 @default.
- W4377029863 creator A5064862039 @default.
- W4377029863 creator A5071733656 @default.
- W4377029863 creator A5077152188 @default.
- W4377029863 creator A5090273676 @default.
- W4377029863 creator A5091814150 @default.
- W4377029863 date "2023-05-18" @default.
- W4377029863 modified "2023-10-17" @default.
- W4377029863 title "Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification" @default.
- W4377029863 cites W1982791774 @default.
- W4377029863 cites W2010457001 @default.
- W4377029863 cites W2020541351 @default.
- W4377029863 cites W2032580087 @default.
- W4377029863 cites W2080666748 @default.
- W4377029863 cites W2130410032 @default.
- W4377029863 cites W2168133698 @default.
- W4377029863 cites W2214074259 @default.
- W4377029863 cites W2282752578 @default.
- W4377029863 cites W2346273585 @default.
- W4377029863 cites W2762299909 @default.
- W4377029863 cites W2770026599 @default.
- W4377029863 cites W2794480084 @default.
- W4377029863 cites W2811224930 @default.
- W4377029863 cites W2886125669 @default.
- W4377029863 cites W2890325820 @default.
- W4377029863 cites W2898789672 @default.
- W4377029863 cites W2916458303 @default.
- W4377029863 cites W3002770500 @default.
- W4377029863 cites W3014185549 @default.
- W4377029863 cites W3093815480 @default.
- W4377029863 cites W3094802395 @default.
- W4377029863 cites W3108862937 @default.
- W4377029863 cites W3112108625 @default.
- W4377029863 cites W3134217762 @default.
- W4377029863 cites W4220983679 @default.
- W4377029863 cites W4221065117 @default.
- W4377029863 cites W4225731526 @default.
- W4377029863 cites W4229336024 @default.
- W4377029863 cites W4283271244 @default.
- W4377029863 cites W4286512367 @default.
- W4377029863 cites W4289654059 @default.
- W4377029863 cites W4296456774 @default.
- W4377029863 cites W4323320159 @default.
- W4377029863 doi "https://doi.org/10.1101/2023.05.15.540305" @default.
- W4377029863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37292835" @default.
- W4377029863 hasPublicationYear "2023" @default.
- W4377029863 type Work @default.
- W4377029863 citedByCount "0" @default.
- W4377029863 crossrefType "posted-content" @default.
- W4377029863 hasAuthorship W4377029863A5000081957 @default.
- W4377029863 hasAuthorship W4377029863A5004828733 @default.
- W4377029863 hasAuthorship W4377029863A5006697675 @default.
- W4377029863 hasAuthorship W4377029863A5007408598 @default.
- W4377029863 hasAuthorship W4377029863A5014630772 @default.
- W4377029863 hasAuthorship W4377029863A5016883047 @default.
- W4377029863 hasAuthorship W4377029863A5021636620 @default.
- W4377029863 hasAuthorship W4377029863A5034417710 @default.
- W4377029863 hasAuthorship W4377029863A5037460404 @default.
- W4377029863 hasAuthorship W4377029863A5051004969 @default.
- W4377029863 hasAuthorship W4377029863A5055064927 @default.
- W4377029863 hasAuthorship W4377029863A5056892173 @default.
- W4377029863 hasAuthorship W4377029863A5064862039 @default.
- W4377029863 hasAuthorship W4377029863A5071733656 @default.
- W4377029863 hasAuthorship W4377029863A5077152188 @default.
- W4377029863 hasAuthorship W4377029863A5090273676 @default.
- W4377029863 hasAuthorship W4377029863A5091814150 @default.
- W4377029863 hasBestOaLocation W43770298631 @default.
- W4377029863 hasConcept C104317684 @default.
- W4377029863 hasConcept C126322002 @default.
- W4377029863 hasConcept C127716648 @default.
- W4377029863 hasConcept C143998085 @default.
- W4377029863 hasConcept C150194340 @default.
- W4377029863 hasConcept C162317418 @default.
- W4377029863 hasConcept C18431079 @default.
- W4377029863 hasConcept C196166836 @default.
- W4377029863 hasConcept C2778461978 @default.
- W4377029863 hasConcept C3020404979 @default.
- W4377029863 hasConcept C502942594 @default.
- W4377029863 hasConcept C54355233 @default.
- W4377029863 hasConcept C553184892 @default.
- W4377029863 hasConcept C60644358 @default.
- W4377029863 hasConcept C64618202 @default.
- W4377029863 hasConcept C70721500 @default.
- W4377029863 hasConcept C71924100 @default.
- W4377029863 hasConcept C72563966 @default.
- W4377029863 hasConcept C86803240 @default.
- W4377029863 hasConceptScore W4377029863C104317684 @default.