FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377029887> ?p ?o ?g. }

• W4377029887 abstract "<div>Abstract<p>MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specifically conjugated duocarmycin-based antibody–drug conjugate (ADC), comprising a humanized cysteine-engineered IgG1 monoclonal antibody with low pmol/L binding affinity towards both human and cynomolgus MET. <i>In vitro</i> studies showed that BYON3521 internalizes efficiently upon MET binding and induces both target- and bystander-mediated cell killing. BYON3521 showed good potency and full efficacy in <i>MET</i>-amplified and high MET–expressing cancer cell lines; in moderate and low MET–expressing cancer cell lines good potencies and partial efficacy were observed. In mouse xenograft models, BYON3521 showed significant antitumor activity upon single-dose administration in multiple non-<i>MET</i>–amplified tumor types with low, moderate, and high MET expression, including complete tumor remissions in models with moderate MET expression. In the repeat-dose Good Laboratory Practice (GLP) safety assessment in cynomolgus monkeys, BYON3521 was well tolerated and based on the observed toxicities and their reversibility, the highest non-severely toxic dose was set at 15 mg/kg. A human pharmacokinetics (PK) model was derived from the PK data from the cynomolgus safety assessments, and the minimal efficacious dose in humans is estimated to be in the range of 3 to 4 mg/kg. In all, our nonclinical data suggests that BYON3521 is a safe ADC with potential for clinical benefit in patients. A first-in-human dose-escalation study is currently ongoing to determine the maximum tolerated dose and recommended dose for expansion (NCT05323045).</p></div>" @default.
• W4377029887 created "2023-05-19" @default.
• W4377029887 creator A5000924696 @default.
• W4377029887 creator A5005904115 @default.
• W4377029887 creator A5020381194 @default.
• W4377029887 creator A5027060657 @default.
• W4377029887 creator A5029181928 @default.
• W4377029887 creator A5035984434 @default.
• W4377029887 creator A5038119899 @default.
• W4377029887 creator A5040263621 @default.
• W4377029887 creator A5042814751 @default.
• W4377029887 creator A5043054584 @default.
• W4377029887 creator A5045221367 @default.
• W4377029887 creator A5071373994 @default.
• W4377029887 creator A5072937628 @default.
• W4377029887 creator A5073452219 @default.
• W4377029887 creator A5075519055 @default.
• W4377029887 creator A5081518257 @default.
• W4377029887 creator A5081777682 @default.
• W4377029887 creator A5083069711 @default.
• W4377029887 creator A5084368000 @default.
• W4377029887 creator A5086850545 @default.
• W4377029887 creator A5088722160 @default.
• W4377029887 date "2023-05-18" @default.
• W4377029887 modified "2023-09-29" @default.
• W4377029887 title "Data from Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody–Drug Conjugate" @default.
• W4377029887 doi "https://doi.org/10.1158/1535-7163.c.6653598.v1" @default.
• W4377029887 hasPublicationYear "2023" @default.
• W4377029887 type Work @default.
• W4377029887 citedByCount "0" @default.
• W4377029887 crossrefType "posted-content" @default.
• W4377029887 hasAuthorship W4377029887A5000924696 @default.
• W4377029887 hasAuthorship W4377029887A5005904115 @default.
• W4377029887 hasAuthorship W4377029887A5020381194 @default.
• W4377029887 hasAuthorship W4377029887A5027060657 @default.
• W4377029887 hasAuthorship W4377029887A5029181928 @default.
• W4377029887 hasAuthorship W4377029887A5035984434 @default.
• W4377029887 hasAuthorship W4377029887A5038119899 @default.
• W4377029887 hasAuthorship W4377029887A5040263621 @default.
• W4377029887 hasAuthorship W4377029887A5042814751 @default.
• W4377029887 hasAuthorship W4377029887A5043054584 @default.
• W4377029887 hasAuthorship W4377029887A5045221367 @default.
• W4377029887 hasAuthorship W4377029887A5071373994 @default.
• W4377029887 hasAuthorship W4377029887A5072937628 @default.
• W4377029887 hasAuthorship W4377029887A5073452219 @default.
• W4377029887 hasAuthorship W4377029887A5075519055 @default.
• W4377029887 hasAuthorship W4377029887A5081518257 @default.
• W4377029887 hasAuthorship W4377029887A5081777682 @default.
• W4377029887 hasAuthorship W4377029887A5083069711 @default.
• W4377029887 hasAuthorship W4377029887A5084368000 @default.
• W4377029887 hasAuthorship W4377029887A5086850545 @default.
• W4377029887 hasAuthorship W4377029887A5088722160 @default.
• W4377029887 hasBestOaLocation W43770298872 @default.
• W4377029887 hasConcept C112705442 @default.
• W4377029887 hasConcept C134306372 @default.
• W4377029887 hasConcept C159654299 @default.
• W4377029887 hasConcept C170493617 @default.
• W4377029887 hasConcept C185592680 @default.
• W4377029887 hasConcept C19106626 @default.
• W4377029887 hasConcept C197336794 @default.
• W4377029887 hasConcept C202751555 @default.
• W4377029887 hasConcept C203014093 @default.
• W4377029887 hasConcept C2776996007 @default.
• W4377029887 hasConcept C2777325958 @default.
• W4377029887 hasConcept C33923547 @default.
• W4377029887 hasConcept C502942594 @default.
• W4377029887 hasConcept C542903549 @default.
• W4377029887 hasConcept C55493867 @default.
• W4377029887 hasConcept C57992300 @default.
• W4377029887 hasConcept C71924100 @default.
• W4377029887 hasConcept C98274493 @default.
• W4377029887 hasConceptScore W4377029887C112705442 @default.
• W4377029887 hasConceptScore W4377029887C134306372 @default.
• W4377029887 hasConceptScore W4377029887C159654299 @default.
• W4377029887 hasConceptScore W4377029887C170493617 @default.
• W4377029887 hasConceptScore W4377029887C185592680 @default.
• W4377029887 hasConceptScore W4377029887C19106626 @default.
• W4377029887 hasConceptScore W4377029887C197336794 @default.
• W4377029887 hasConceptScore W4377029887C202751555 @default.
• W4377029887 hasConceptScore W4377029887C203014093 @default.
• W4377029887 hasConceptScore W4377029887C2776996007 @default.
• W4377029887 hasConceptScore W4377029887C2777325958 @default.
• W4377029887 hasConceptScore W4377029887C33923547 @default.
• W4377029887 hasConceptScore W4377029887C502942594 @default.
• W4377029887 hasConceptScore W4377029887C542903549 @default.
• W4377029887 hasConceptScore W4377029887C55493867 @default.
• W4377029887 hasConceptScore W4377029887C57992300 @default.
• W4377029887 hasConceptScore W4377029887C71924100 @default.
• W4377029887 hasConceptScore W4377029887C98274493 @default.
• W4377029887 hasLocation W43770298871 @default.
• W4377029887 hasLocation W43770298872 @default.
• W4377029887 hasOpenAccess W4377029887 @default.
• W4377029887 hasPrimaryLocation W43770298871 @default.
• W4377029887 hasRelatedWork W2088609615 @default.
• W4377029887 hasRelatedWork W2410442130 @default.
• W4377029887 hasRelatedWork W2436602471 @default.
• W4377029887 hasRelatedWork W2912016889 @default.
• W4377029887 hasRelatedWork W2953758866 @default.
• W4377029887 hasRelatedWork W3148985959 @default.
• W4377029887 hasRelatedWork W4210842440 @default.

• next