FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377030225> ?p ?o ?g. }

• W4377030225 endingPage "116808" @default.
• W4377030225 startingPage "116808" @default.
• W4377030225 abstract "Chronic kidney disease (CKD) is characterized by secondary hyperparathyroidism and an increased risk of hip fractures predominantly related to cortical porosity. Unfortunately, bone mineral density measurements and high-resolution peripheral computed tomography (HR-pQCT) imaging have shortcomings that limit their utility in these patients. Ultrashort echo time magnetic resonance imaging (UTE-MRI) has the potential to overcome these limitations by providing an alternative assessment of cortical porosity. The goal of the current study was to determine if UTE-MRI could detect changes in porosity in an established rat model of CKD. Cy/+ rats (n = 11), an established animal model of CKD-MBD, and their normal littermates (n = 12) were imaged using microcomputed tomography (microCT) and UTE-MRI at 30 and 35 weeks of age (which approximates late-stage kidney disease in humans). Images were obtained at the distal tibia and the proximal femur. Cortical porosity was assessed using the percent porosity (Pore%) calculated from microCT imaging and the porosity index (PI) calculated from UTE-MRI. Correlations between Pore% and PI were also calculated. Cy/+ rats had higher Pore% than normal rats at both skeletal sites at 35 weeks (tibia = 7.13 % +/- 5.59 % vs. 0.51 % +/- 0.09 %, femur = 19.99 % +/- 7.72 % vs. 2.72 % +/- 0.32 %). They also had greater PI at the distal tibia at 30 weeks of age (0.47 +/- 0.06 vs. 0.40 +/- 0.08). However, Pore% and PI were only correlated in the proximal femur at 35 weeks of age (ρ = 0.929, Spearman). These microCT results are consistent with prior studies in this animal model utilizing microCT imaging. The UTE-MRI results were inconsistent, resulting in variable correlations with microCT imaging, which may be related to suboptimal bound and pore water discrimination at higher magnetic field strengths. Nevertheless, UTE-MRI may still provide an additional clinical tool to assess fracture risk without using ionizing radiation in CKD patients." @default.
• W4377030225 created "2023-05-19" @default.
• W4377030225 creator A5000603296 @default.
• W4377030225 creator A5003063631 @default.
• W4377030225 creator A5023746200 @default.
• W4377030225 creator A5036155533 @default.
• W4377030225 creator A5041908437 @default.
• W4377030225 creator A5044149723 @default.
• W4377030225 creator A5047036467 @default.
• W4377030225 creator A5061605908 @default.
• W4377030225 creator A5074659892 @default.
• W4377030225 creator A5074763683 @default.
• W4377030225 creator A5080453305 @default.
• W4377030225 creator A5073178454 @default.
• W4377030225 date "2023-08-01" @default.
• W4377030225 modified "2023-10-17" @default.
• W4377030225 title "Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease" @default.
• W4377030225 cites W1488133456 @default.
• W4377030225 cites W1938867264 @default.
• W4377030225 cites W1969465167 @default.
• W4377030225 cites W1996203364 @default.
• W4377030225 cites W1996667243 @default.
• W4377030225 cites W2005359013 @default.
• W4377030225 cites W2031941775 @default.
• W4377030225 cites W2043368155 @default.
• W4377030225 cites W2043817882 @default.
• W4377030225 cites W2047856826 @default.
• W4377030225 cites W2066428247 @default.
• W4377030225 cites W2091561259 @default.
• W4377030225 cites W2099783744 @default.
• W4377030225 cites W2100835464 @default.
• W4377030225 cites W2107651010 @default.
• W4377030225 cites W2108529411 @default.
• W4377030225 cites W2109392661 @default.
• W4377030225 cites W2116989988 @default.
• W4377030225 cites W2133325671 @default.
• W4377030225 cites W2141651245 @default.
• W4377030225 cites W2143453028 @default.
• W4377030225 cites W2158222136 @default.
• W4377030225 cites W2228646576 @default.
• W4377030225 cites W2321424609 @default.
• W4377030225 cites W2579155188 @default.
• W4377030225 cites W2609761376 @default.
• W4377030225 cites W2619441988 @default.
• W4377030225 cites W2904369333 @default.
• W4377030225 cites W2921350014 @default.
• W4377030225 cites W2943210990 @default.
• W4377030225 cites W2947010024 @default.
• W4377030225 cites W2995962163 @default.
• W4377030225 cites W3017360119 @default.
• W4377030225 cites W3094504847 @default.
• W4377030225 cites W3108503102 @default.
• W4377030225 cites W3164566314 @default.
• W4377030225 cites W3214157019 @default.
• W4377030225 cites W4206930106 @default.
• W4377030225 cites W4236494759 @default.
• W4377030225 doi "https://doi.org/10.1016/j.bone.2023.116808" @default.
• W4377030225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37207990" @default.
• W4377030225 hasPublicationYear "2023" @default.
• W4377030225 type Work @default.
• W4377030225 citedByCount "0" @default.
• W4377030225 crossrefType "journal-article" @default.
• W4377030225 hasAuthorship W4377030225A5000603296 @default.
• W4377030225 hasAuthorship W4377030225A5003063631 @default.
• W4377030225 hasAuthorship W4377030225A5023746200 @default.
• W4377030225 hasAuthorship W4377030225A5036155533 @default.
• W4377030225 hasAuthorship W4377030225A5041908437 @default.
• W4377030225 hasAuthorship W4377030225A5044149723 @default.
• W4377030225 hasAuthorship W4377030225A5047036467 @default.
• W4377030225 hasAuthorship W4377030225A5061605908 @default.
• W4377030225 hasAuthorship W4377030225A5073178454 @default.
• W4377030225 hasAuthorship W4377030225A5074659892 @default.
• W4377030225 hasAuthorship W4377030225A5074763683 @default.
• W4377030225 hasAuthorship W4377030225A5080453305 @default.
• W4377030225 hasConcept C105702510 @default.
• W4377030225 hasConcept C126322002 @default.
• W4377030225 hasConcept C126838900 @default.
• W4377030225 hasConcept C141071460 @default.
• W4377030225 hasConcept C142724271 @default.
• W4377030225 hasConcept C143409427 @default.
• W4377030225 hasConcept C178790620 @default.
• W4377030225 hasConcept C185592680 @default.
• W4377030225 hasConcept C2776541429 @default.
• W4377030225 hasConcept C2776886416 @default.
• W4377030225 hasConcept C2777236700 @default.
• W4377030225 hasConcept C2777425516 @default.
• W4377030225 hasConcept C2778653478 @default.
• W4377030225 hasConcept C2780091579 @default.
• W4377030225 hasConcept C2780554211 @default.
• W4377030225 hasConcept C2781451080 @default.
• W4377030225 hasConcept C2989005 @default.
• W4377030225 hasConcept C6648577 @default.
• W4377030225 hasConcept C71924100 @default.
• W4377030225 hasConceptScore W4377030225C105702510 @default.
• W4377030225 hasConceptScore W4377030225C126322002 @default.
• W4377030225 hasConceptScore W4377030225C126838900 @default.
• W4377030225 hasConceptScore W4377030225C141071460 @default.
• W4377030225 hasConceptScore W4377030225C142724271 @default.

• next