FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377047276> ?p ?o ?g. }

• W4377047276 endingPage "142" @default.
• W4377047276 startingPage "141" @default.
• W4377047276 abstract "PURPOSE: Patients with inflammatory breast cancer (IBC) are at high risk for lymphedema due to their need for axillary lymph node dissection (ALND) and high-dose regional nodal radiation. LYMPHA (Lymphatic Microsurgical Preventive Healing Approach) is increasingly offered for prevention of upper extremity lymphedema after breast cancer treatment. Prior studies focus on intraoperative and postoperative lymphedema risk factors, some of which are unknown preoperatively when the decision to perform LYMPHA is made. This study aimed to identify preoperative lymphedema risk factors in the high-risk IBC population. METHODS: Retrospective review of our institution’s IBC program database was conducted. All patients with IBC who underwent neoadjuvant chemotherapy (NAC) and modified radical mastectomy (MRM) with adjuvant radiation were reviewed. The primary outcome was self-reported lymphedema development. Secondary endpoints were time from IBC diagnosis, mastectomy, or radiation completion to lymphedema diagnosis. Multivariable logistic regression analysis was used to identify preoperative lymphedema risk factors, while controlling for number of lymph nodes removed during ALND, number of positive lymph nodes, presence of residual disease on final pathology, and need for adjuvant systemic therapy. Additionally, the subset of patients who underwent breast reconstruction was reviewed and descriptive statistics of reconstructive techniques performed. RESULTS: Of 356 patients (86% Stage 3, 14% Stage 4) who underwent NAC, MRM and radiation, complete data on risk factors were available for 134 (37.6%). Mean age at diagnosis was 51 years (range 22-89 years). Forty-seven percent of patients developed lymphedema during treatment and 87% had ≥5 lymph nodes removed. Four percent developed lymphedema preoperatively (mean 138 days, median 149 days after IBC diagnosis), 14.6% developed lymphedema after surgery and before radiation (mean 51 days, median 45 days postoperatively), and 81.7% developed lymphedema after radiation (mean 470 days, median 271 days after radiation). Obesity (BMI > 30) (OR 2.7, CI 1.2-6.4, p = 0.02) and non-white race (OR 4.5, CI 1.2-23, p = 0.04) were preoperative risk factors for lymphedema. Reconstruction data was available for 91.3% of patients (n=325). Of these, 78.5% (n=255) did not receive reconstruction. Among those who underwent reconstruction (n=70, 21.5%), most patients were younger than 50 years (n=41, 58.6%). Most who underwent reconstruction were white (n=63, 90.0% versus n=2, 2.86% black and n=5, 7.14% other). Ethnicity data was available for 48 patients (68.6%). The majority of patients were non-Hispanic (n=46, 95.83%). BMI data was available for 48 patients and the majority had BMI <30 (n=29, 60.42%). CONCLUSION: Patients with IBC are at high risk of lymphedema, with 47% of patients in our study developing self-reported lymphedema. While need for NAC, ALND, and PMRT are known risk factors, we identified obesity and non-white race as additional lymphedema risk factors in this population. Given this high prevalence, LYMPHA should be considered for all patients with IBC. Larger, prospective studies are needed to further evaluate potential racial disparities in lymphedema development." @default.
• W4377047276 created "2023-05-19" @default.
• W4377047276 creator A5001573761 @default.
• W4377047276 creator A5003348942 @default.
• W4377047276 creator A5006032358 @default.
• W4377047276 creator A5006821769 @default.
• W4377047276 creator A5019396960 @default.
• W4377047276 creator A5025439922 @default.
• W4377047276 creator A5038988386 @default.
• W4377047276 creator A5046872343 @default.
• W4377047276 creator A5073648529 @default.
• W4377047276 creator A5091174578 @default.
• W4377047276 date "2023-05-01" @default.
• W4377047276 modified "2023-09-27" @default.
• W4377047276 title "SP33. Optimizing Patient Selection for Lympha in Patients with Inflammatory Breast Cancer" @default.
• W4377047276 doi "https://doi.org/10.1097/01.gox.0000938476.57742.a6" @default.
• W4377047276 hasPublicationYear "2023" @default.
• W4377047276 type Work @default.
• W4377047276 citedByCount "0" @default.
• W4377047276 crossrefType "journal-article" @default.
• W4377047276 hasAuthorship W4377047276A5001573761 @default.
• W4377047276 hasAuthorship W4377047276A5003348942 @default.
• W4377047276 hasAuthorship W4377047276A5006032358 @default.
• W4377047276 hasAuthorship W4377047276A5006821769 @default.
• W4377047276 hasAuthorship W4377047276A5019396960 @default.
• W4377047276 hasAuthorship W4377047276A5025439922 @default.
• W4377047276 hasAuthorship W4377047276A5038988386 @default.
• W4377047276 hasAuthorship W4377047276A5046872343 @default.
• W4377047276 hasAuthorship W4377047276A5073648529 @default.
• W4377047276 hasAuthorship W4377047276A5091174578 @default.
• W4377047276 hasBestOaLocation W43770472761 @default.
• W4377047276 hasConcept C121608353 @default.
• W4377047276 hasConcept C126322002 @default.
• W4377047276 hasConcept C126838900 @default.
• W4377047276 hasConcept C141071460 @default.
• W4377047276 hasConcept C143998085 @default.
• W4377047276 hasConcept C146357865 @default.
• W4377047276 hasConcept C151730666 @default.
• W4377047276 hasConcept C2777129934 @default.
• W4377047276 hasConcept C2777757722 @default.
• W4377047276 hasConcept C2780212769 @default.
• W4377047276 hasConcept C2780849966 @default.
• W4377047276 hasConcept C2781392513 @default.
• W4377047276 hasConcept C2908949552 @default.
• W4377047276 hasConcept C509974204 @default.
• W4377047276 hasConcept C530470458 @default.
• W4377047276 hasConcept C71924100 @default.
• W4377047276 hasConcept C86803240 @default.
• W4377047276 hasConceptScore W4377047276C121608353 @default.
• W4377047276 hasConceptScore W4377047276C126322002 @default.
• W4377047276 hasConceptScore W4377047276C126838900 @default.
• W4377047276 hasConceptScore W4377047276C141071460 @default.
• W4377047276 hasConceptScore W4377047276C143998085 @default.
• W4377047276 hasConceptScore W4377047276C146357865 @default.
• W4377047276 hasConceptScore W4377047276C151730666 @default.
• W4377047276 hasConceptScore W4377047276C2777129934 @default.
• W4377047276 hasConceptScore W4377047276C2777757722 @default.
• W4377047276 hasConceptScore W4377047276C2780212769 @default.
• W4377047276 hasConceptScore W4377047276C2780849966 @default.
• W4377047276 hasConceptScore W4377047276C2781392513 @default.
• W4377047276 hasConceptScore W4377047276C2908949552 @default.
• W4377047276 hasConceptScore W4377047276C509974204 @default.
• W4377047276 hasConceptScore W4377047276C530470458 @default.
• W4377047276 hasConceptScore W4377047276C71924100 @default.
• W4377047276 hasConceptScore W4377047276C86803240 @default.
• W4377047276 hasIssue "5S" @default.
• W4377047276 hasLocation W43770472761 @default.
• W4377047276 hasLocation W43770472762 @default.
• W4377047276 hasLocation W43770472763 @default.
• W4377047276 hasOpenAccess W4377047276 @default.
• W4377047276 hasPrimaryLocation W43770472761 @default.
• W4377047276 hasRelatedWork W2014527910 @default.
• W4377047276 hasRelatedWork W2136694409 @default.
• W4377047276 hasRelatedWork W2201694488 @default.
• W4377047276 hasRelatedWork W2395768217 @default.
• W4377047276 hasRelatedWork W2466949046 @default.
• W4377047276 hasRelatedWork W2921766577 @default.
• W4377047276 hasRelatedWork W3196220378 @default.
• W4377047276 hasRelatedWork W4232990594 @default.
• W4377047276 hasRelatedWork W4247344182 @default.
• W4377047276 hasRelatedWork W4319161112 @default.
• W4377047276 hasVolume "11" @default.
• W4377047276 isParatext "false" @default.
• W4377047276 isRetracted "false" @default.
• W4377047276 workType "article" @default.